International Journal of Endocrinology and Metabolism International Journal of Endocrinology and Metabolism Int J Endocrinol Metab http://www.endometabol.com 1726-913X 1726-9148 10.5812/ijem en jalali 2017 5 28 gregorian 2017 5 28 2 2
en Body Mass Index in Turner Syndrome Before and After Growth Hormone Therapy Body Mass Index in Turner Syndrome Before and After Growth Hormone Therapy research-article research-article Introduction

Turner syndrome is the most common chromosomal abnormality in females. Girls with Turner syndrome have an abmormal or missing X choromosme that causes short stature, ovarian failure, renovascular and cardiac anomalies. It has been shown that there is a tendency to obesity in the Turner syndrome. This prospective study has been done to evaluate whether body mass index (BMI) is different in girls with Turner syndrome as compared to normal girls and also whether it is affected by growth hormone (GH) therapy.

Materials and Methods

Materials and methods: BMI (kg/m2) was calculated for 21 girls with Turner syndrome at baseline (at the diagnosis), and after 6 months treatement with GH D.l IUJkglday subcutaneously at bedtime. The results were analyzed with the SPSS and the statistical significance was established at a p<0.05.

Results

The mean age at diagnosis was 1l.2±2.9 years. Height and weight were reduced in Turner syndrome as compared to those of normal girls. BMI's was 18.44±3.32 and 18.78±4.21 kglm2 before and after 6-month period of GH therapy, respectively. No significant change in BMI was observed (p=0.334).

Conclusions

Conclusion: This study documented that shortterm hGH administration was not associated with changes in BMI in girls with Turner syndrome.

Introduction

Turner syndrome is the most common chromosomal abnormality in females. Girls with Turner syndrome have an abmormal or missing X choromosme that causes short stature, ovarian failure, renovascular and cardiac anomalies. It has been shown that there is a tendency to obesity in the Turner syndrome. This prospective study has been done to evaluate whether body mass index (BMI) is different in girls with Turner syndrome as compared to normal girls and also whether it is affected by growth hormone (GH) therapy.

Materials and Methods

Materials and methods: BMI (kg/m2) was calculated for 21 girls with Turner syndrome at baseline (at the diagnosis), and after 6 months treatement with GH D.l IUJkglday subcutaneously at bedtime. The results were analyzed with the SPSS and the statistical significance was established at a p<0.05.

Results

The mean age at diagnosis was 1l.2±2.9 years. Height and weight were reduced in Turner syndrome as compared to those of normal girls. BMI's was 18.44±3.32 and 18.78±4.21 kglm2 before and after 6-month period of GH therapy, respectively. No significant change in BMI was observed (p=0.334).

Conclusions

Conclusion: This study documented that shortterm hGH administration was not associated with changes in BMI in girls with Turner syndrome.

Turner syndrome;Body mass index;Growth hormone Turner syndrome;Body mass index;Growth hormone 78 81 http://www.endometabol.com/index.php?page=article&article_id=9660 Vakili R Vakili R Emqs~}e~u oospmtim|ryooonfo{ryo}3u~d Metobolism, IR Iran ; Emqs~}e~u oospmtim|ryooonfo{ryo}3u~d Metobolism, IR Iran Emqs~}e~u oospmtim|ryooonfo{ryo}3u~d Metobolism, IR Iran ; Emqs~}e~u oospmtim|ryooonfo{ryo}3u~d Metobolism, IR Iran Horri M Horri M Department of Pediatric Cardiology, Mashhad University of Medical Sciences, IR Iran Department of Pediatric Cardiology, Mashhad University of Medical Sciences, IR Iran Mothaghi H Mothaghi H Department of Pediatric Cardiology, Mashhad University of Medical Sciences, IR Iran Department of Pediatric Cardiology, Mashhad University of Medical Sciences, IR Iran
en Leptin Levels in Obese and Non-Obese African and Caucasian Subjects With Type 2 Diabetes Leptin Levels in Obese and Non-Obese African and Caucasian Subjects With Type 2 Diabetes research-article research-article

It has previously been demonstrated that circulating levels of leptin show ethnic differences when controlled for the confounding influence of adiposity. This study examined leptin levels in non-obese and obese subjects with type 2 diabetes of African versus Caucasian origin.

Materials and Methods

Non-obese and obese subjects with type 2 diabetes of either African origin living in Dar es Salaam, Tanzania (n=22) or Caucasian origin living in Malmo, Sweden (n=24) were studied by taking a fasting sample for analysis of insulin and leptin after an overnight fast. All subjects were treated with metformin alone or with sulfonylurea with or without addition of metformin.

Results

It was found that age, BMI, waist circumference,blood pressure and fasting glucose or insulin did not differ between Africans and Caucasians, when divided into obese and nonobese subjects. However, leptin levels were 50°/., higher in the African subjects than in the Caucasians, when controlled for gender and BMI (P=O.01).

Conclusion

We conclude that both in non-obese and obese subjects with type 2 diabetes, leptin levels are higher among subjects of African origin than of Caucasian origin. This may be related to higher risk of cardiovascular diseases in these subjects.

It has previously been demonstrated that circulating levels of leptin show ethnic differences when controlled for the confounding influence of adiposity. This study examined leptin levels in non-obese and obese subjects with type 2 diabetes of African versus Caucasian origin.

Materials and Methods

Non-obese and obese subjects with type 2 diabetes of either African origin living in Dar es Salaam, Tanzania (n=22) or Caucasian origin living in Malmo, Sweden (n=24) were studied by taking a fasting sample for analysis of insulin and leptin after an overnight fast. All subjects were treated with metformin alone or with sulfonylurea with or without addition of metformin.

Results

It was found that age, BMI, waist circumference,blood pressure and fasting glucose or insulin did not differ between Africans and Caucasians, when divided into obese and nonobese subjects. However, leptin levels were 50°/., higher in the African subjects than in the Caucasians, when controlled for gender and BMI (P=O.01).

Conclusion

We conclude that both in non-obese and obese subjects with type 2 diabetes, leptin levels are higher among subjects of African origin than of Caucasian origin. This may be related to higher risk of cardiovascular diseases in these subjects.

Diabetes;Leptin;Obesity Diabetes;Leptin;Obesity 61 65 http://www.endometabol.com/index.php?page=article&article_id=9596 Abbas ZG Abbas ZG Abbas Medical Center, Tanzania; Muhimbili University College of Health Science, Tanzania Abbas Medical Center, Tanzania; Muhimbili University College of Health Science, Tanzania Lutale JK Lutale JK Muhimbili University College of Health Science, Tanzania Muhimbili University College of Health Science, Tanzania Ahren Be Ahren Be Department of Medicine, l}nduowws{}}y, SE-221 84 LUND, Sweden ; Department of Medicine, l}nduowws{}}y, SE-221 84 LUND, Sweden Department of Medicine, l}nduowws{}}y, SE-221 84 LUND, Sweden ; Department of Medicine, l}nduowws{}}y, SE-221 84 LUND, Sweden
en Vascular Cell Adhesion Molecule-l (VCAM-l) in Graves' Disease: Its Association to Thyroid Status and Thyroid Receptor Stimulating Antibodies Vascular Cell Adhesion Molecule-l (VCAM-l) in Graves' Disease: Its Association to Thyroid Status and Thyroid Receptor Stimulating Antibodies research-article research-article Materials and Methods

Patients were given fixed daily dose of 20 mg carbimazole for 3 months and blood samples were collected at baseline and end of the study. Thirty-eight patients were recruited from the Endocrine Clinic, Hospital Universiti Kebangsaan Malaysia, consisting of 26 females and 12 males, age ranging from 16 to 65 years. Blood samples collected before and at end of study were analysed for TSH, Free TJ, Free T4J thyroid receptor stimulating antibodies (TRAb), sVCAM-1, sICAM-1 and lL-6.

Soluble vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) have been shown to be elevated in patients with Graves'disease and may play significant roles in the pathogenesis of the disease. The objective of this study was to measure the levels of sVCAM-1, sICAM-l, IL-6 and thyroid receptor stimulating antibodies (TRAb) in a cohort of hyperthyroid patients and determine their associations to thyroid hormones status, before and after 3 months thexapy with carbimazole.

Results

TRAb level of ≤10 to U/L was taken to be negative, while TRAb level of >10 U/L was considered as positive. Twenty-six patients (68%) were TRAb positive (TRAb+) and 12 patients (30%) were TRAb negative (TRAb-). Median TRAb in TRAb+ patients was 23 UIL at baseline, declining to 16.7 U/L (p<0.00l) in the third 3 month. Sexum sVCAM-1 levels were significantly elevated in TRAb+ patients compared to TRAb-(860 versus 499 nglmL, p<0.00l). The level decreased significantly to 537 nglmL with treatment but remained higher than in TRAb-patients (p=0.003). Irrespective of TRAb status, all but one patient had elevated serum sICAM-l levels that remained unaffected by carbimazole therapy. In contrast, IL-6 levels of hyperthyroid patients were within the reference range of 1.+14.1 pglmL. Baseline and post-treatment sVCAM-l, and not TRAb levels, were significantly correlated to thyroid hormones.

Conclusion

Compared to other inflammatory markers, sVCAM-l showed significant correlation to thyrOid stimulating antibodies and was most sensitive to changes in thyroid status. The significance of these findings in relation to Graves' disease warrants further investigation.

Materials and Methods

Patients were given fixed daily dose of 20 mg carbimazole for 3 months and blood samples were collected at baseline and end of the study. Thirty-eight patients were recruited from the Endocrine Clinic, Hospital Universiti Kebangsaan Malaysia, consisting of 26 females and 12 males, age ranging from 16 to 65 years. Blood samples collected before and at end of study were analysed for TSH, Free TJ, Free T4J thyroid receptor stimulating antibodies (TRAb), sVCAM-1, sICAM-1 and lL-6.

Soluble vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) have been shown to be elevated in patients with Graves'disease and may play significant roles in the pathogenesis of the disease. The objective of this study was to measure the levels of sVCAM-1, sICAM-l, IL-6 and thyroid receptor stimulating antibodies (TRAb) in a cohort of hyperthyroid patients and determine their associations to thyroid hormones status, before and after 3 months thexapy with carbimazole.

Results

TRAb level of ≤10 to U/L was taken to be negative, while TRAb level of >10 U/L was considered as positive. Twenty-six patients (68%) were TRAb positive (TRAb+) and 12 patients (30%) were TRAb negative (TRAb-). Median TRAb in TRAb+ patients was 23 UIL at baseline, declining to 16.7 U/L (p<0.00l) in the third 3 month. Sexum sVCAM-1 levels were significantly elevated in TRAb+ patients compared to TRAb-(860 versus 499 nglmL, p<0.00l). The level decreased significantly to 537 nglmL with treatment but remained higher than in TRAb-patients (p=0.003). Irrespective of TRAb status, all but one patient had elevated serum sICAM-l levels that remained unaffected by carbimazole therapy. In contrast, IL-6 levels of hyperthyroid patients were within the reference range of 1.+14.1 pglmL. Baseline and post-treatment sVCAM-l, and not TRAb levels, were significantly correlated to thyroid hormones.

Conclusion

Compared to other inflammatory markers, sVCAM-l showed significant correlation to thyrOid stimulating antibodies and was most sensitive to changes in thyroid status. The significance of these findings in relation to Graves' disease warrants further investigation.

VCAM-1;Graves;disease;TRAb;Inflammation VCAM-1;Graves;disease;TRAb;Inflammation 66 73 http://www.endometabol.com/index.php?page=article&article_id=9606 Wan Nazaimoon WM Wan Nazaimoon WM Institute for Medical Research, Malaysia ; Institute for Medical Research, Malaysia Institute for Medical Research, Malaysia ; Institute for Medical Research, Malaysia Ismail IS Ismail IS University Malaya Medical Center, Malaysia University Malaya Medical Center, Malaysia Tan HJ Tan HJ Faculty of Medicine, Universiti Kebangsaan, Malaysia Faculty of Medicine, Universiti Kebangsaan, Malaysia Kamaruddin NA Kamaruddin NA Faculty of Medicine, Universiti Kebangsaan, Malaysia Faculty of Medicine, Universiti Kebangsaan, Malaysia Khalid AK Khalid AK Faculty of Medicine, Universiti Kebangsaan, Malaysia Faculty of Medicine, Universiti Kebangsaan, Malaysia
en Relation Between Pre-and Post-Dexamethasone Test Cortisol Values in Cushing's Disease Relation Between Pre-and Post-Dexamethasone Test Cortisol Values in Cushing's Disease research-article research-article Introduction

The dexamethasone test has been widely used for diagnosing hypercortisolism.

Materials and Methods

We assessed the relationship between the basal and suppressed cortisol values in urine and plasma during a low-dose dexamethasone test in patients with proved Cushing's disease.

Results

A statistically highly significant correlation was found (for urine cortisol: r = 0.66, P <0.0001; for plasma cortisol: r = 0.94, P <0.003).

Conclusions

These findings imply that the lower the pretest cortisol values, the lower are the suppressed values. In patients with suspected Cushing's syndrome and only slightly elevated cortisol excretjon or low plasma concentration, the outcome might easily be considered normal. This point is particularly pertinent when assessing the post-treatment status.

Introduction

The dexamethasone test has been widely used for diagnosing hypercortisolism.

Materials and Methods

We assessed the relationship between the basal and suppressed cortisol values in urine and plasma during a low-dose dexamethasone test in patients with proved Cushing's disease.

Results

A statistically highly significant correlation was found (for urine cortisol: r = 0.66, P <0.0001; for plasma cortisol: r = 0.94, P <0.003).

Conclusions

These findings imply that the lower the pretest cortisol values, the lower are the suppressed values. In patients with suspected Cushing's syndrome and only slightly elevated cortisol excretjon or low plasma concentration, the outcome might easily be considered normal. This point is particularly pertinent when assessing the post-treatment status.

Cushing's syndrome;Adrenal cortex function test;Hypercortisolism Cushing's syndrome;Adrenal cortex function test;Hypercortisolism 74 77 http://www.endometabol.com/index.php?page=article&article_id=9635 Lindholm J Lindholm J Department of Medicine, Holstebro Hospital, Denmark Department of Medicine, Holstebro Hospital, Denmark Hagen C Hagen C Department of Endocrinology, Odense University Hospital, Denmark Department of Endocrinology, Odense University Hospital, Denmark Kosteljanetz M Kosteljanetz M Department of Neurosurgery, University Hospital, Denmark Department of Neurosurgery, University Hospital, Denmark Kristensen Led Kristensen Led Department of Medicine, Herlev University Hospital, Denmark Department of Medicine, Herlev University Hospital, Denmark Laurberg P Laurberg P Department of Endoc{oooooymneamgo{ginopiumvorgkyspital, Denmark ; Department of Endoc{oooooymneamgo{ginopiumvorgkyspital, Denmark Department of Endoc{oooooymneamgo{ginopiumvorgkyspital, Denmark ; Department of Endoc{oooooymneamgo{ginopiumvorgkyspital, Denmark Weeke J Weeke J Department of Medicine, Aarhus University Hospital, Denmark Department of Medicine, Aarhus University Hospital, Denmark
en A Study of 558 Cases of Cold Thyroid Nodules, 1991-1999; Comparison to a Decade Earlier A Study of 558 Cases of Cold Thyroid Nodules, 1991-1999; Comparison to a Decade Earlier research-article research-article Introduction

Although thyroid nodules are usually benign, malignancy must always be ruled out. Many efforts have been made to find. malignant nodules and reduce the number of unnecessary operations. In this study, our aim was to examine, after the more extensive use of fine needle aspiration (FNA), whether the incidence of cancer finding has been increased.

Materials and Methods

We studied retrospectively the medical records of the patients who were operated during 1991 through 1999 in the university hospital setting. Age, sex, FNA and complete pathologic reports, and whether the lesion was multinodular or a solitary nodule, were studied. The results were then compared with those of a previous study performed in the same center a decade earlier.

Results

Patients' age was 39±12.7 year with benign nodules, and 45±15 year with malignant lesions (P<0.001). The frequencies of pathologic lesions were: multinodular goiter, 59.5%; thyroid cancer, 30.5%; thyroid adenoma, 7.7%; and thyroiditis, 2.3%. There was no relationship between being multinodular or single nodule on one hand, and malignancy on the other. The prevalence of colloid nodular goiter in a study performed a decade earlier was 81.8%; thyroid cancer 10.2%; adenomas 6.5%; and thyroiditis 1.5'Yu. FNAs were done for 50% in the present study, whereas this was done only in 10% of patients in the earlier study.

Conclusions

It seems that the more widespread use of FNA is an important reason of significant increase in cancer finding.

Introduction

Although thyroid nodules are usually benign, malignancy must always be ruled out. Many efforts have been made to find. malignant nodules and reduce the number of unnecessary operations. In this study, our aim was to examine, after the more extensive use of fine needle aspiration (FNA), whether the incidence of cancer finding has been increased.

Materials and Methods

We studied retrospectively the medical records of the patients who were operated during 1991 through 1999 in the university hospital setting. Age, sex, FNA and complete pathologic reports, and whether the lesion was multinodular or a solitary nodule, were studied. The results were then compared with those of a previous study performed in the same center a decade earlier.

Results

Patients' age was 39±12.7 year with benign nodules, and 45±15 year with malignant lesions (P<0.001). The frequencies of pathologic lesions were: multinodular goiter, 59.5%; thyroid cancer, 30.5%; thyroid adenoma, 7.7%; and thyroiditis, 2.3%. There was no relationship between being multinodular or single nodule on one hand, and malignancy on the other. The prevalence of colloid nodular goiter in a study performed a decade earlier was 81.8%; thyroid cancer 10.2%; adenomas 6.5%; and thyroiditis 1.5'Yu. FNAs were done for 50% in the present study, whereas this was done only in 10% of patients in the earlier study.

Conclusions

It seems that the more widespread use of FNA is an important reason of significant increase in cancer finding.

Thyroid nodule;Colloid nodular goiter;thyroid cancer;Fine needle aspiration Thyroid nodule;Colloid nodular goiter;thyroid cancer;Fine needle aspiration http://www.endometabol.com/index.php?page=article&article_id=9667 Nakbjavani M Nakbjavani M Eovos}oneognenmowskoomoyreeag|acon}w, Valmmssrhosy}uml,tenvaof_o{~avs{~ybovdMedical Sciences and Health Services, IR.Iran Eovos}oneognenmowskoomoyreeag|acon}w, Valmmssrhosy}uml,tenvaof_o{~avs{~ybovdMedical Sciences and Health Services, IR.Iran Esteghamati AR Esteghamati AR Khalafpour M Khalafpour M
en Timing of the Effect of Iodine Supplementation on Intelligence Quotients of Schoolchildren Timing of the Effect of Iodine Supplementation on Intelligence Quotients of Schoolchildren research-article research-article

Iodine deficiency is the most important preventable cause of mental deficiency. The aim of this study was to specify the phase during fetal and postnatal development when iodine supplementation would have optimum effect on the prevention of brain damage.

Materials and Methods

Forty schoolchildren aged 7-13 years, from the previously iodine deficient villages of Kiga and Randan, were divided into 3 subgroups: in subgroup I the mother had received iodized oil 1-4 years prior to conception and infant consumed iodized salt from the age 14 years onwards; in subgroup II mothers received iodized oil during pregnancy and the child received iodized salt from the age 2-4 years and in subgroup III the child received iodized oil injection from age 1-3 and iodized salt from 3-6 years of age onwards. Serum T4, T3, TSH and TJ uptake and urine iodide concentrations were measured. Bender-Guestalt and Raven tests were employed for psychomotor evaluation. A group of 40 age and sex matched schoolchildren from Tehran served as controls.

Results

Mean age of subgroups I, II and III were 8.9±1.7, 9.4±1.4 and 1l.9±1.2 years, respectively. Serum T4, T3, TSH and urinary iodine concentrations were normal in all children. Urinary iodine and serum T4, T3 and TSH concentration did not differ between the 3 subgroups. Mean IQ was higher in subgroup I (102±7), as compared to subgroup II (93±10, p<0.002) and subgroup III (9S±10, p<0.0S). Mean IQ of subgroup I was not significantly different from age-matched controls, but a significant decrease in IQ was evident in subgroups II (93±10 vs 109±8, p<0.002) and III (96±10 vs 114±11,p<0.001 ), as compared to the control children.

Conclusion

It is concluded that children whose mothers received iodide supplementation before conception had normal IQs of significantly higher values than those whose mothers received iodine during pregnancy and the children who received iodine after birth.

Iodine deficiency is the most important preventable cause of mental deficiency. The aim of this study was to specify the phase during fetal and postnatal development when iodine supplementation would have optimum effect on the prevention of brain damage.

Materials and Methods

Forty schoolchildren aged 7-13 years, from the previously iodine deficient villages of Kiga and Randan, were divided into 3 subgroups: in subgroup I the mother had received iodized oil 1-4 years prior to conception and infant consumed iodized salt from the age 14 years onwards; in subgroup II mothers received iodized oil during pregnancy and the child received iodized salt from the age 2-4 years and in subgroup III the child received iodized oil injection from age 1-3 and iodized salt from 3-6 years of age onwards. Serum T4, T3, TSH and TJ uptake and urine iodide concentrations were measured. Bender-Guestalt and Raven tests were employed for psychomotor evaluation. A group of 40 age and sex matched schoolchildren from Tehran served as controls.

Results

Mean age of subgroups I, II and III were 8.9±1.7, 9.4±1.4 and 1l.9±1.2 years, respectively. Serum T4, T3, TSH and urinary iodine concentrations were normal in all children. Urinary iodine and serum T4, T3 and TSH concentration did not differ between the 3 subgroups. Mean IQ was higher in subgroup I (102±7), as compared to subgroup II (93±10, p<0.002) and subgroup III (9S±10, p<0.0S). Mean IQ of subgroup I was not significantly different from age-matched controls, but a significant decrease in IQ was evident in subgroups II (93±10 vs 109±8, p<0.002) and III (96±10 vs 114±11,p<0.001 ), as compared to the control children.

Conclusion

It is concluded that children whose mothers received iodide supplementation before conception had normal IQs of significantly higher values than those whose mothers received iodine during pregnancy and the children who received iodine after birth.

Iodine supplementation;Intelligence quotient;Iodine deficiency;Urinary iodine Iodine supplementation;Intelligence quotient;Iodine deficiency;Urinary iodine http://www.endometabol.com/index.php?page=article&article_id=9668 Salarkia N Salarkia N Endocrine Research Center, _iuiooelbo}usitioni~erwo} gomnooooyssmwocwsl Yn~k}tu=3{}m|www Beheshti University of Medical Sciences, IR Iran Endocrine Research Center, _iuiooelbo}usitioni~erwo} gomnooooyssmwocwsl Yn~k}tu=3{}m|www Beheshti University of Medical Sciences, IR Iran Mirmiran P Mirmiran P Endocrine Research Center, _iuiooelbo}usitioni~erwo} gomnooooyssmwocwsl Yn~k}tu=3{}m|www Beheshti University of Medical Sciences, IR Iran Endocrine Research Center, _iuiooelbo}usitioni~erwo} gomnooooyssmwocwsl Yn~k}tu=3{}m|www Beheshti University of Medical Sciences, IR Iran Azizi F Azizi F Endocrine Research Center, _iuiooelbo}usitioni~erwo} gomnooooyssmwocwsl Yn~k}tu=3{}m|www Beheshti University of Medical Sciences, IR Iran ; Endocrine Research Center, _iuiooelbo}usitioni~erwo} gomnooooyssmwocwsl Yn~k}tu=3{}m|www Beheshti University of Medical Sciences, IR Iran Endocrine Research Center, _iuiooelbo}usitioni~erwo} gomnooooyssmwocwsl Yn~k}tu=3{}m|www Beheshti University of Medical Sciences, IR Iran ; Endocrine Research Center, _iuiooelbo}usitioni~erwo} gomnooooyssmwocwsl Yn~k}tu=3{}m|www Beheshti University of Medical Sciences, IR Iran
en Effects of Purified Omega-3 Fatty Acids on Serum Lipoproteins and Malondialdehyde in Postmenopausal Fat Women Receiving Hormone Replacement Therapy Effects of Purified Omega-3 Fatty Acids on Serum Lipoproteins and Malondialdehyde in Postmenopausal Fat Women Receiving Hormone Replacement Therapy research-article research-article Introduction

Regular intake of n-3 fatty acids of marine origin have desirable effects on serum lipoproteins and reduce coronary vascular disease (CVD). n-3 fatty acid supplementation decreased serum triglyceride concentrations in studies in which most of the subjects were male. The effects of n-3 fatty acids supplementation in fat women especially postmenopausal fat women have received little attention. The aim of this study was to determine whether purified n-3 fatty acids have desirable effects on serum lipoproteins, malondialdehyde (MDA) and lipoprotein risk factors for CVD in postmenopausal fat women receiving hormone replacement therapy (HRT).

Materials and Methods

In a double-blind, placebo-controlled trial of parallel design, 35 postmenopausal women receiving hormone replacement therapy were randomly allocated to receive 2 g purified n-3 fatty acids or placebo for 10 weeks. Serum lipoproteins and MDA were determined on days 0 and 70.

Results

Serum levels of triglycerides (TG) decreased significantly in the n-3 fatty acids group at the end of study compared to the initial values, and also compared to control group (26%, p< 0.003 and 29%, p< 0.01, respectively)_In the n-3 fatty acids group, serum levels of TG/HDL-C decreased significantly at the end of the study compared to initial values and, at the end of the study, compared to control group as well (23 %, P <0.05 and 28%, p< 0.05).

Conclusion

Supplementation with purified n-3 fatty acids can favorably influence selected CHD risk factors, particulary by achieving marked reduction in serum TG and TG/HDL-C levels in postmenopausal fat women receiving HRT.

Introduction

Regular intake of n-3 fatty acids of marine origin have desirable effects on serum lipoproteins and reduce coronary vascular disease (CVD). n-3 fatty acid supplementation decreased serum triglyceride concentrations in studies in which most of the subjects were male. The effects of n-3 fatty acids supplementation in fat women especially postmenopausal fat women have received little attention. The aim of this study was to determine whether purified n-3 fatty acids have desirable effects on serum lipoproteins, malondialdehyde (MDA) and lipoprotein risk factors for CVD in postmenopausal fat women receiving hormone replacement therapy (HRT).

Materials and Methods

In a double-blind, placebo-controlled trial of parallel design, 35 postmenopausal women receiving hormone replacement therapy were randomly allocated to receive 2 g purified n-3 fatty acids or placebo for 10 weeks. Serum lipoproteins and MDA were determined on days 0 and 70.

Results

Serum levels of triglycerides (TG) decreased significantly in the n-3 fatty acids group at the end of study compared to the initial values, and also compared to control group (26%, p< 0.003 and 29%, p< 0.01, respectively)_In the n-3 fatty acids group, serum levels of TG/HDL-C decreased significantly at the end of the study compared to initial values and, at the end of the study, compared to control group as well (23 %, P <0.05 and 28%, p< 0.05).

Conclusion

Supplementation with purified n-3 fatty acids can favorably influence selected CHD risk factors, particulary by achieving marked reduction in serum TG and TG/HDL-C levels in postmenopausal fat women receiving HRT.

n-3 fatty acids;Triglycerides;Postmenopausal women;HDL-C;Malondialdehyde n-3 fatty acids;Triglycerides;Postmenopausal women;HDL-C;Malondialdehyde 87 94 http://www.endometabol.com/index.php?page=article&article_id=9669 Shidfar F Shidfar F Wgxo|monthogl~}|rivion}n{wmmtfonemmtioamrsoiunkwwrsity of Medical Sciences, P.O. Box 15875-4199, IR Iran ; Wgxo|monthogl~}|rivion}n{wmmtfonemmtioamrsoiunkwwrsity of Medical Sciences, P.O. Box 15875-4199, IR Iran Wgxo|monthogl~}|rivion}n{wmmtfonemmtioamrsoiunkwwrsity of Medical Sciences, P.O. Box 15875-4199, IR Iran ; Wgxo|monthogl~}|rivion}n{wmmtfonemmtioamrsoiunkwwrsity of Medical Sciences, P.O. Box 15875-4199, IR Iran Keshavarz A Keshavarz A School of Public Health, Tehran University of Medical Sciences, IR Iran School of Public Health, Tehran University of Medical Sciences, IR Iran Jalali M Jalali M Wgxo|monthogl~}|rivion}n{wmmtfonemmtioamrsoiunkwwrsity of Medical Sciences, P.O. Box 15875-4199, IR Iran Wgxo|monthogl~}|rivion}n{wmmtfonemmtioamrsoiunkwwrsity of Medical Sciences, P.O. Box 15875-4199, IR Iran Miri R Miri R Shaheed Beheshti University of Medical Sciences Shaheed Beheshti University of Medical Sciences Amri A Amri A Wgxo|monthogl~}|rivion}n{wmmtfonemmtioamrsoiunkwwrsity of Medical Sciences, P.O. Box 15875-4199, IR Iran Wgxo|monthogl~}|rivion}n{wmmtfonemmtioamrsoiunkwwrsity of Medical Sciences, P.O. Box 15875-4199, IR Iran Shidfar SH Shidfar SH dMemorial Hospital, University of Massachusetts, USA dMemorial Hospital, University of Massachusetts, USA
en Correlation Between Serum Levels of Cholesterol and Homocysteine with Oxidative Stress in Hypothyroid Patients Correlation Between Serum Levels of Cholesterol and Homocysteine with Oxidative Stress in Hypothyroid Patients research-article research-article Introduction

A bnormaJities in cholesterol and homo­ cysteine metabolism have been reported in thyroid diseases. Since elevated lev­ els of both parameters are involved in atherogenesis, and thyroid hormones are modu­ lators of oxidative stress. In this study, the corre­ lation between serum levels of cholesterol, and homocysteine, and oxidative stress was assessed in patients with thyroid dysfunction.

Materials and Methods

A total of 60 patients with thyroid dysfunction (30 with hypothyroid­ ism and 30 with hyperthyroidism) were included in this study. Thirty apparently healthy sex and age-matched individuals were :;elected as control group. The mean age of hypothyroid, hyperthy­ roid and control groups were 43±7.7, 39±12 and 40±7.9 years, respectively. Serum levels of homo­ cysteine were measured by HPLC and those of thyroid hormones (T3, T", T3 R. uptake and TSH) by radioimmunoassay techniques. Levels of total antioxidant capacity, lipid profiles and creatinine were determined by standard methods in Cobas Mira Autoanalyzer.

Results

The mean±SD levels of homocysteine in hyperthyroid, hypothyroid and control groups were 7.79±1.44, 17.09±6.93 and 8.08±1.92 pmol/L, respectively. Comparing with control group sig­ nificant elevation was noted in hypothyroid pa­ tients (p=O.OOOl). Significant correlation between serum levels of creatinine and that of homocysteine was observed (r=0.86, p= 0.0001). Singnifi­ cant elevation in the levels of total cholesterol and LDL-C were observed in hypothyroid pa­ tients (p<0.05). Significant reduction in the se­ rum antioxidant capacity was found in patients suffering from hypothyroidism (p=O.Ol). But not in hyperthyroid subjects. Significant inverse cor­ relation was observed between serum levels of antioxidant capacity and those of homocysteine (r=-O.79, p=0.02), total cholesterol (r=-O.93, p= 0.02) and LDL-C (r=-0.83, p=O.OO1) in hypothyroid pa­ tients. This correlations were not significant in the hyperthyroid and control groups (p > 0.05).

Conclusions

The correlation between serum lev­ els of homocysteine, total cholesterol and LDL-C with total antioxidant capacity in hypothyroid­ ism suggests that there is an overproduction of free radicals in these patients. It is concluded that the enhanced production of free radicals might be an important contributing factor in ab­ normalities seen in homocysteine and choles­ terol metabolism.

Introduction

A bnormaJities in cholesterol and homo­ cysteine metabolism have been reported in thyroid diseases. Since elevated lev­ els of both parameters are involved in atherogenesis, and thyroid hormones are modu­ lators of oxidative stress. In this study, the corre­ lation between serum levels of cholesterol, and homocysteine, and oxidative stress was assessed in patients with thyroid dysfunction.

Materials and Methods

A total of 60 patients with thyroid dysfunction (30 with hypothyroid­ ism and 30 with hyperthyroidism) were included in this study. Thirty apparently healthy sex and age-matched individuals were :;elected as control group. The mean age of hypothyroid, hyperthy­ roid and control groups were 43±7.7, 39±12 and 40±7.9 years, respectively. Serum levels of homo­ cysteine were measured by HPLC and those of thyroid hormones (T3, T", T3 R. uptake and TSH) by radioimmunoassay techniques. Levels of total antioxidant capacity, lipid profiles and creatinine were determined by standard methods in Cobas Mira Autoanalyzer.

Results

The mean±SD levels of homocysteine in hyperthyroid, hypothyroid and control groups were 7.79±1.44, 17.09±6.93 and 8.08±1.92 pmol/L, respectively. Comparing with control group sig­ nificant elevation was noted in hypothyroid pa­ tients (p=O.OOOl). Significant correlation between serum levels of creatinine and that of homocysteine was observed (r=0.86, p= 0.0001). Singnifi­ cant elevation in the levels of total cholesterol and LDL-C were observed in hypothyroid pa­ tients (p<0.05). Significant reduction in the se­ rum antioxidant capacity was found in patients suffering from hypothyroidism (p=O.Ol). But not in hyperthyroid subjects. Significant inverse cor­ relation was observed between serum levels of antioxidant capacity and those of homocysteine (r=-O.79, p=0.02), total cholesterol (r=-O.93, p= 0.02) and LDL-C (r=-0.83, p=O.OO1) in hypothyroid pa­ tients. This correlations were not significant in the hyperthyroid and control groups (p > 0.05).

Conclusions

The correlation between serum lev­ els of homocysteine, total cholesterol and LDL-C with total antioxidant capacity in hypothyroid­ ism suggests that there is an overproduction of free radicals in these patients. It is concluded that the enhanced production of free radicals might be an important contributing factor in ab­ normalities seen in homocysteine and choles­ terol metabolism.

Hyperhomocysteinemia;Oxidative stress;Thyroid dysfunction;Serum lipids;Anti-oxidant capacity Hyperhomocysteinemia;Oxidative stress;Thyroid dysfunction;Serum lipids;Anti-oxidant capacity 103 109 http://www.endometabol.com/index.php?page=article&article_id=9831 Rahbani-Nobar M Rahbani-Nobar M Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran Bahrami A Bahrami A Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran ; Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran ; Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran Norazarian M Norazarian M Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran Dolatkhah H Dolatkhah H Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran Tro.Cxl}uw3weqz{~ Center, Tabriz University of Medical Sciences, I.R.Iran