Comparison of Two Calorie-Reduced Diets of Different Carbohydrate and Fiber Contents and a Simple Dietary Advice Aimed to Modify Carbohydrate Intake on Glycemic Control and Inflammatory Markers in Type 2 Diabetes: A Randomized Trial

Authors Information
Article Notes and Dates
To Cite : Ghalandari H, Kamalpour M, Alimadadi A, Nasrollahzadeh J. Comparison of Two Calorie-Reduced Diets of Different Carbohydrate and Fiber Contents and a Simple Dietary Advice Aimed to Modify Carbohydrate Intake on Glycemic Control and Inflammatory Markers in Type 2 Diabetes: A Randomized Trial, Int J Endocrinol Metab. Online ahead of Print ;In Press(In Press):e12089. doi: 10.5812/ijem.12089.
Copyright: Copyright © 0, International Journal of Endocrinology and Metabolism. .
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010; 87(1): 4-14[DOI][PubMed]
  • 2. American Diabetes A. (2) Classification and diagnosis of diabetes. Diabetes Care. 2015; 38 Suppl[DOI][PubMed]
  • 3. Fox CS, Golden SH, Anderson C, Bray GA, Burke LE, de Boer IH, et al. Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association. Diabetes Care. 2015; 38(9): 1777-803[DOI][PubMed]
  • 4. American Diabetes A, Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, et al. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2008; 31 Suppl 1-78[DOI][PubMed]
  • 5. American Diabetes A. Standards of medical care in diabetes--2014. Diabetes Care. 2014; 37 Suppl 1-80[DOI][PubMed]
  • 6. Nordmann AJ, Nordmann A, Briel M, Keller U, Yancy WJ, Brehm BJ, et al. Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006; 166(3): 285-93[DOI][PubMed]
  • 7. Wheeler ML, Dunbar SA, Jaacks LM, Karmally W, Mayer-Davis EJ, Wylie-Rosett J, et al. Macronutrients, food groups, and eating patterns in the management of diabetes: a systematic review of the literature, 2010. Diabetes Care. 2012; 35(2): 434-45[DOI][PubMed]
  • 8. Breneman CB, Tucker L. Dietary fibre consumption and insulin resistance - the role of body fat and physical activity. Br J Nutr. 2013; 110(2): 375-83[DOI][PubMed]
  • 9. Chandalia M, Garg A, Lutjohann D, von Bergmann K, Grundy SM, Brinkley LJ. Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med. 2000; 342(19): 1392-8[DOI][PubMed]
  • 10. Evert AB, Boucher JL, Cypress M, Dunbar SA, Franz MJ, Mayer-Davis EJ, et al. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care. 2014; 37 Suppl 1-43[DOI][PubMed]
  • 11. Maiorino MI, Bellastella G, Giugliano D, Esposito K. Cooling down inflammation in type 2 diabetes: how strong is the evidence for cardiometabolic benefit? Endocrine. 2017; 55(2): 360-5[DOI][PubMed]
  • 12. Guest CB, Park MJ, Johnson DR, Freund GG. The implication of proinflammatory cytokines in type 2 diabetes. Front Biosci. 2008; 13: 5187-94[PubMed]
  • 13. Ireton-Jones CS. Krause's Food & the Nutrition Care Process. 2017; : 17-51
  • 14. Kirk JK, Graves DE, Craven TE, Lipkin EW, Austin M, Margolis KL. Restricted-carbohydrate diets in patients with type 2 diabetes: a meta-analysis. J Am Diet Assoc. 2008; 108(1): 91-100[DOI][PubMed]
  • 15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28(7): 412-9[PubMed]
  • 16. Shanik MH, Xu Y, Skrha J, Dankner R, Zick Y, Roth J. Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care. 2008; 31 Suppl 2-8[DOI][PubMed]
  • 17. Cicero AFG, Derosa G, Bove M, Imola F, Borghi C, Gaddi AV. Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet. Mediterranean J Nutr Metabol. 2009; 3(1): 47-54[DOI]
  • 18. Ziai SA, Larijani B, Akhoondzadeh S, Fakhrzadeh H, Dastpak A, Bandarian F, et al. Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients. J Ethnopharmacol. 2005; 102(2): 202-7[DOI][PubMed]
  • 19. Gibb RD, McRorie JJ, Russell DA, Hasselblad V, D'Alessio DA. Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus. Am J Clin Nutr. 2015; 102(6): 1604-14[DOI][PubMed]
  • 20. Robertson MD, Wright JW, Loizon E, Debard C, Vidal H, Shojaee-Moradie F, et al. Insulin-sensitizing effects on muscle and adipose tissue after dietary fiber intake in men and women with metabolic syndrome. J Clin Endocrinol Metab. 2012; 97(9): 3326-32[DOI][PubMed]
  • 21. Bosutti A, Malaponte G, Zanetti M, Castellino P, Heer M, Guarnieri G, et al. Calorie restriction modulates inactivity-induced changes in the inflammatory markers C-reactive protein and pentraxin-3. J Clin Endocrinol Metab. 2008; 93(8): 3226-9[DOI][PubMed]
  • 22. Khoo J, Piantadosi C, Duncan R, Worthley SG, Jenkins A, Noakes M, et al. Comparing effects of a low-energy diet and a high-protein low-fat diet on sexual and endothelial function, urinary tract symptoms, and inflammation in obese diabetic men. J Sex Med. 2011; 8(10): 2868-75[DOI][PubMed]
  • 23. Lottenberg AM, Fan PL, Buonacorso V. Effects of dietary fiber intake on inflammation in chronic diseases. Einstein (Sao Paulo). 2010; 8(2): 254-8[DOI][PubMed]
  • 24. Tedelind S, Westberg F, Kjerrulf M, Vidal A. Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World J Gastroenterol. 2007; 13(20): 2826-32[PubMed]
  • 25. Kuo SM. The interplay between fiber and the intestinal microbiome in the inflammatory response. Adv Nutr. 2013; 4(1): 16-28[DOI][PubMed]
  • 26. King DE, Egan BM, Woolson RF, Mainous A3, Al-Solaiman Y, Jesri A. Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level. Arch Intern Med. 2007; 167(5): 502-6[DOI][PubMed]
  • 27. King DE, Mainous A3, Egan BM, Woolson RF, Geesey ME. Effect of psyllium fiber supplementation on C-reactive protein: the trial to reduce inflammatory markers (TRIM). Ann Fam Med. 2008; 6(2): 100-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiaion Alert via Google Reader

Cited By:

International Journal of Endocrinology and Metabolism accepts terms & conditions of:

International Committee of Medical Journal Editors (ICMJE) Citedby Linking DOI enabled Crossref iThenticate COPE Cross Check