International Journal of Endocrinology and Metabolism

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Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia

Laura Ohana Marques Coelho de Carvalho 1 , Raymundo Miguel Garcia Lora 1 , Claudia Renata Rezende Penna 2 and Izabel Calland Ricarte Beserra 3 , *
Authors Information
1 Postgraduate Student of Federal University of Rio de Janeiro, Brazil
2 Head of Radiology Unit, Instituto de Puericultura e Pediatria Martagao Gesteira, Federal University of Rio de Janeiro, Brazil
3 Head of Endocrinology Unit, Instituto de Puericultura e Pediatria Martagao Gesteira, Federal University of Rio de Janeiro and Professor of Pediatric Endocrinology, Federal University of Rio de Janeiro, Brazil
Article information
  • International Journal of Endocrinology and Metabolism: January 2017, 15 (1); e13259
  • Published Online: December 31, 2016
  • Article Type: Research Article
  • Received: July 26, 2016
  • Revised: November 28, 2016
  • Accepted: December 10, 2016
  • DOI: 10.5812/ijem.40611

To Cite: Ohana Marques Coelho de Carvalho L, Miguel Garcia Lora R, Renata Rezende Penna C, Calland Ricarte Beserra I. Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia, Int J Endocrinol Metab. 2017 ;15(1):e13259. doi: 10.5812/ijem.40611.

Abstract
Copyright: Copyright © 2017, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Methods
3. Results
4. Discussion
References
  • 1. Claahsen-van der Grinten HL, Otten BJ, Stikkelbroeck MM, Sweep FC, Hermus AR. Testicular adrenal rest tumours in congenital adrenal hyperplasia. Best Pract Res Clin Endocrinol Metab. 2009; 23(2): 209-20[DOI][PubMed]
  • 2. Claahsen-van der Grinten HL, Hermus AR, Otten BJ. Testicular adrenal rest tumours in congenital adrenal hyperplasia. Int J Pediatr Endocrinol. 2009; 2009: 624823[DOI][PubMed]
  • 3. Martinez-Aguayo A, Rocha A, Rojas N, Garcia C, Parra R, Lagos M, et al. Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2007; 92(12): 4583-9[DOI][PubMed]
  • 4. Sullivan JG, Gohel M, Kinder RB. Ectopic adrenocortical tissue found at groin exploration in children: incidence in relation to diagnosis, age and sex. BJU Int. 2005; 95(3): 407-10[DOI][PubMed]
  • 5. Fernandes VO, Barros AI, Quidute AR, Montenegro AP, Fontenele EG, Sales AP, et al. [Bilateral testicular tumors caused by congenital adrenal rest hyperplasia]. Arq Bras Endocrinol Metabol. 2009; 53(8): 1052-8[PubMed]
  • 6. Claahsen-van der Grinten HL, Otten BJ, Sweep FC, Span PN, Ross HA, Meuleman EJ, et al. Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue. J Clin Endocrinol Metab. 2007; 92(9): 3674-80[DOI][PubMed]
  • 7. Stikkelbroeck NM, Otten BJ, Pasic A, Jager GJ, Sweep CG, Noordam K, et al. High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2001; 86(12): 5721-8[DOI][PubMed]
  • 8. Stikkelbroeck NM, Suliman HM, Otten BJ, Hermus AR, Blickman JG, Jager GJ. Testicular adrenal rest tumours in postpubertal males with congenital adrenal hyperplasia: sonographic and MR features. Eur Radiol. 2003; 13(7): 1597-603[DOI][PubMed]
  • 9. Claahsen-van der Grinten HL, Sweep FC, Blickman JG, Hermus AR, Otten BJ. Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Eur J Endocrinol. 2007; 157(3): 339-44[DOI][PubMed]
  • 10. Benvenga S, Smedile G, Lo Giudice F, Trimarchi F. Testicular adrenal rests: evidence for luteinizing hormone receptors and for distinct types of testicular nodules differing for their autonomization. Eur J Endocrinol. 1999; 141(3): 231-7[PubMed]
  • 11. Mouritsen A, Jorgensen N, Main KM, Schwartz M, Juul A. Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation. Int J Androl. 2010; 33(3): 521-7[DOI][PubMed]
  • 12. Poyrazoglu S, Saka N, Agayev A, Yekeler E. Prevalence of testicular microlithiasis in males with congenital adrenal hyperplasia and its association with testicular adrenal rest tumors. Horm Res Paediatr. 2010; 73(6): 443-8[DOI][PubMed]
  • 13. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child. 1970; 45(239): 13-23[PubMed]
  • 14. Greulich WW, Pyle SI. Radiologic atlas of skeletal development of the hand and wrist. 1959;
  • 15. Cakir ED, Mutlu FS, Eren E, Pasa AO, Saglam H, Tarim O. Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia. J Clin Res Pediatr Endocrinol. 2012; 4(2): 94-100[DOI][PubMed]
  • 16. Newm MIL, Ghizzoni KLS. An update of Congenital Adrenal Hyperplasia. Lifshitz F. Pediatric Endocrinology. 2007; : 227-45
  • 17. Furst DE, Saag KG. Glucocorticoid withdrawal. 2013;
  • 18. Goede J, Hack WWM, Sijstermans K, Van der Voort-Doedens LM, Van der Ploeg T, Meij-de Vries A, et al. Normative values for testicular volume measured by ultrasonography in a normal population from infancy to adolescence. Hormone Res Paediatr. 2011; 76(1): 56-64
  • 19. Lenz S, Giwercman A, Elsborg A, Cohr KH, Jelnes JE, Carlsen E, et al. Ultrasonic testicular texture and size in 444 men from the general population: correlation to semen quality. Eur Urol. 1993; 24(2): 231-8[PubMed]
  • 20. Peggy P, Francois D, Francois T, Christine C, Veronique K, Emmanuel S, et al. Adrenal rest tissue in gonads in 70 French patients with classical congenital adrenal hyperplasia (21 hydroxylase deficiency). Endocrine Abstracts. 2007; 14: 632
  • 21. Kang MJ, Kim JH, Lee SH, Lee YA, Shin CH, Yang SW. The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. Endocr J. 2011; 58(6): 501-8[PubMed]
  • 22. Falhammar H, Nystrom HF, Ekstrom U, Granberg S, Wedell A, Thoren M. Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia. Eur J Endocrinol. 2012; 166(3): 441-9[DOI][PubMed]
  • 23. Nermoen I, Rorvik J, Holmedal SH, Hykkerud DL, Fougner KJ, Svartberg J, et al. High frequency of adrenal myelolipomas and testicular adrenal rest tumours in adult Norwegian patients with classical congenital adrenal hyperplasia because of 21-hydroxylase deficiency. Clin Endocrinol (Oxf). 2011; 75(6): 753-9[DOI][PubMed]
  • 24. Artas H, Orhan I. Scrotal calculi. J Ultrasound Med. 2007; 26(12): 1775-9[PubMed]
  • 25. Rutgers JL, Young RH, Scully RE. The testicular "tumor" of the adrenogenital syndrome. A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders. Am J Surg Pathol. 1988; 12(7): 503-13[PubMed]
  • 26. Sasagawa I, Nakada T, Kazama T, Satomi S, Katayama T, Matuda S. Testicular microlithiasis in male infertility. Urol Int. 1988; 43(6): 368-9[PubMed]
  • 27. Kim HK, Crotty E. Bilateral testicular adrenal rests in a boy with congenital adrenal hyperplasia. Pediatr Radiol. 2010; 40 Suppl 1[DOI][PubMed]
  • 28. Claahsen-van der Grinten HL, Otten BJ, Takahashi S, Meuleman EJ, Hulsbergen-van de Kaa C, Sweep FC, et al. Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients. J Clin Endocrinol Metab. 2007; 92(2): 612-5[DOI][PubMed]
  • 29. Marchini GS, Cocuzza M, Pagani R, Torricelli FC, Hallak J, Srougi M. Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review. Sao Paulo Med J. 2011; 129(5): 346-51[PubMed]
  • 30. Nebesio TD, Eugster EA. Growth and reproductive outcomes in congenital adrenal hyperplasia. Int J Pediatr Endocrinol. 2010; 2010: 298937[DOI][PubMed]
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