International Journal of Endocrinology and Metabolism

Published by: Kowsar

The Effect of n-3 Polyunsaturated Fatty Acids Supplementation on Serum Irisin in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial

Samaneh Ansari 1 , Mahmoud Djalali 1 , Niyaz Mohammadzadeh Honarvar 1 , Maryam Mazaherioun 2 , Mahnaz Zarei 1 , Fahimeh Agh 3 , Zahra Gholampour 4 and Mohammad Hassan Javanbakht 1 , *
Authors Information
1 Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IR Iran
2 Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, IR Iran
3 Faculty of Nutritional Sciences and Dietetics, Iran University of Medical Sciences, Tehran, IR Iran
4 Farahzad Health Care Center, Iran University of Medical Sciences, Tehran, IR Iran
Article information
  • International Journal of Endocrinology and Metabolism: January 2017, 15 (1); e13261
  • Published Online: January 21, 2017
  • Article Type: Research Article
  • Received: July 4, 2016
  • Revised: December 7, 2016
  • Accepted: January 11, 2017
  • DOI: 10.5812/ijem.40614

To Cite: Ansari S, Djalali M, Mohammadzadeh Honarvar N, Mazaherioun M, Zarei M, et al. The Effect of n-3 Polyunsaturated Fatty Acids Supplementation on Serum Irisin in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Int J Endocrinol Metab. 2017 ;15(1):e13261. doi: 10.5812/ijem.40614.

Abstract
Copyright: Copyright © 2017, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Diabetes. 2014;
  • 2. Mediacentre. 2014;
  • 3. Khaksari M, Sajadi M, Hajizadeh S. Effect of dietary fish oil on wound healing in diabetic rats. J Physiol Pharmacol. 2000; 3: 181-91
  • 4. Rastmanesh R, Mehrabi Y. The effect of omega-3 fatty acids on inflammatory markers, insulin sensitivity and metabolic control in patients with diabetes type 2. Pajoohandeh. 2005; 5(9): 281-7
  • 5. Pedersen BK, Åkerström TCA, Nielsen AR, Fischer CP. Role of myokines in exercise and metabolism. J Appl Physiol. 2007; 103(3): 1093-8
  • 6. Sanchis-Gomar F, Perez-Quilis C. Irisinemia: a novel concept to coin in clinical medicine? Ann Nutr Metab. 2013; 63(1-2): 60-1[DOI][PubMed]
  • 7. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012; 481(7382): 463-8[DOI][PubMed]
  • 8. Polyzos SA, Kountouras J, Shields K, Mantzoros CS. Irisin: a renaissance in metabolism? Metabolism. 2013; 62(8): 1037-44[DOI][PubMed]
  • 9. Hamann A, Flier JS, Lowell BB. Obesity after genetic ablation of brown adipose tissue. Z Ernahrungswiss. 1998; 37 Suppl 1: 1-7[PubMed]
  • 10. Yang X, Enerback S, Smith U. Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Obes Res. 2003; 11(10): 1182-91[DOI][PubMed]
  • 11. Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index. Peptides. 2013; 39: 125-30[DOI][PubMed]
  • 12. Liu JJ, Wong MD, Toy WC, Tan CS, Liu S, Ng XW, et al. Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complications. 2013; 27(4): 365-9[DOI][PubMed]
  • 13. Peter PR, Park KH, Huh JY, Wedick NM, Mantzoros CS. Circulating irisin levels are not affected by coffee intake: a randomized controlled trial. PLoS One. 2014; 9(4)[DOI][PubMed]
  • 14. Gouni-Berthold I, Berthold HK, Huh JY, Berman R, Spenrath N, Krone W, et al. Effects of lipid-lowering drugs on irisin in human subjects in vivo and in human skeletal muscle cells ex vivo. PLoS One. 2013; 8(9)[DOI][PubMed]
  • 15. Seo DY, Kwak HB, Lee SR, Cho YS, Song IS, Kim N, et al. Effects of aged garlic extract and endurance exercise on skeletal muscle FNDC-5 and circulating irisin in high-fat-diet rat models. Nutr Res Pract. 2014; 8(2): 177-82[DOI][PubMed]
  • 16. Adachi H, Nakano H, Yamamoto K, Nakata M, Bekki H, Honma T, et al. Ezetimibe ameliorates atherogenic lipids profiles, insulin resistance and hepatocyte growth factor in obese patients with hypercholesterolemia. Lipids Health Dis. 2015; 14: 1[DOI][PubMed]
  • 17. Liu J. Irisin as an exercise-stimulated hormone binding crosstalk between organs. Eur Rev Med Pharmacol Sci. 2015; 19(2): 316-21[PubMed]
  • 18. Gamas L, Matafome P, Seica R. Irisin and Myonectin Regulation in the Insulin Resistant Muscle: Implications to Adipose Tissue: Muscle Crosstalk. J Diabetes Res. 2015; 2015: 359159[DOI][PubMed]
  • 19. Yan B, Shi X, Zhang H, Pan L, Ma Z, Liu S, et al. Association of serum irisin with metabolic syndrome in obese Chinese adults. PLoS One. 2014; 9(4)[DOI][PubMed]
  • 20. Choi YK, Kim MK, Bae KH, Seo HA, Jeong JY, Lee WK, et al. Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract. 2013; 100(1): 96-101[DOI][PubMed]
  • 21. Tsuchiya Y, Ando D, Goto K, Kiuchi M, Yamakita M, Koyama K. High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. Tohoku J Exp Med. 2014; 233(2): 135-40[PubMed]
  • 22. Sun C, Hu Y, Chu Z, Huang J, Zhang L. The effect of brain-derived neurotrophic factor on angiogenesis. J Huazhong Univ Sci Technolog Med Sci. 2009; 29(2): 139-43[DOI][PubMed]
  • 23. Irving BA, Still CD, Argyropoulos G. Does IRISIN Have a BRITE Future as a Therapeutic Agent in Humans? Curr Obes Rep. 2014; 3: 235-41[DOI][PubMed]
  • 24. Novelle MG, Contreras C, Romero-Pico A, Lopez M, Dieguez C. Irisin, two years later. Int J Endocrinol. 2013; 2013: 746281[DOI][PubMed]
  • 25. Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab. 2013; 98(4)-78[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader