International Journal of Endocrinology and Metabolism

Published by: Kowsar

The Effects of Testosterone Deficiency and Its Replacement on Inflammatory Markers in Rats: A Pilot Study

Kok-Yong Chin 1 , * and Soelaiman Ima-Nirwana 1
Authors Information
1 Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
Article information
  • International Journal of Endocrinology and Metabolism: January 2017, 15 (1); e13268
  • Published Online: January 9, 2017
  • Article Type: Brief Report
  • Received: October 14, 2016
  • Revised: November 28, 2016
  • Accepted: January 4, 2017
  • DOI: 10.5812/ijem.43053

To Cite: Chin K, Ima-Nirwana S. The Effects of Testosterone Deficiency and Its Replacement on Inflammatory Markers in Rats: A Pilot Study, Int J Endocrinol Metab. 2017 ; 15(1):e13268. doi: 10.5812/ijem.43053.

Copyright © 2017, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Chin KY, Soelaiman IN, Mohamed IN, Ahmad F, Ramli ES, Aminuddin A, et al. Sex hormones in Malay and Chinese men in Malaysia: are there age and race differences? Clinics (Sao Paulo). 2013; 68(2): 159-66[PubMed]
  • 2. Ferrucci L, Corsi A, Lauretani F, Bandinelli S, Bartali B, Taub DD, et al. The origins of age-related proinflammatory state. Blood. 2005; 105(6): 2294-9[DOI][PubMed]
  • 3. Sasaki M, Fujii Y, Iwamoto M, Ikadai H. Effect of sex steroids on Babesia microti infection in mice. Am J Trop Med Hyg. 2013; 88(2): 367-75[DOI][PubMed]
  • 4. Rettew JA, Huet-Hudson YM, Marriott I. Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod. 2008; 78(3): 432-7[DOI][PubMed]
  • 5. Ginaldi L, Di Benedetto MC, De Martinis M. Osteoporosis, inflammation and ageing. Immun Ageing. 2005; 2: 14[DOI][PubMed]
  • 6. Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011; 10(3): 319-29[DOI][PubMed]
  • 7. Chin KY, Soelaiman IN, Naina Mohamed I, Shahar S, Teng NI, Suhana Mohd Ramli E, et al. Testosterone is associated with age-related changes in bone health status, muscle strength and body composition in men. Aging Male. 2012; 15(4): 240-5[DOI][PubMed]
  • 8. Oskui PM, French WJ, Herring MJ, Mayeda GS, Burstein S, Kloner RA. Testosterone and the cardiovascular system: a comprehensive review of the clinical literature. J Am Heart Assoc. 2013; 2(6): 272[DOI][PubMed]
  • 9. Bobjer J, Katrinaki M, Tsatsanis C, Lundberg Giwercman Y, Giwercman A. Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study. PLoS One. 2013; 8(4): 61466[DOI][PubMed]
  • 10. Maggio M, Basaria S, Ble A, Lauretani F, Bandinelli S, Ceda GP, et al. Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men. J Clin Endocrinol Metab. 2006; 91(1): 345-7[DOI][PubMed]
  • 11. Maggio M, Blackford A, Taub D, Carducci M, Ble A, Metter EJ, et al. Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. J Androl. 2006; 27(6): 725-8[DOI][PubMed]
  • 12. Maggio M, Snyder PJ, De Vita F, Ceda GP, Milaneschi Y, Lauretani F, et al. Effects of transdermal testosterone treatment on inflammatory markers in elderly males. Endocr Pract. 2014; 20(11): 1170-7[DOI][PubMed]
  • 13. Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004; 89(7): 3313-8[DOI][PubMed]
  • 14. Freeman BM, Mountain DJ, Brock TC, Chapman JR, Kirkpatrick SS, Freeman MB, et al. Low testosterone elevates interleukin family cytokines in a rodent model: a possible mechanism for the potentiation of vascular disease in androgen-deficient males. J Surg Res. 2014; 190(1): 319-27[DOI][PubMed]
  • 15. Mendes LO, Scarano WR, Rochel-Maia SS, Fioruci-Fontaneli BA, Chuffa LG, Martinez FE. Testosterone therapy differently regulates the anti- and pro-inflammatory cytokines in the plasma and prostate of rats submitted to chronic ethanol consumption (UChB). Am J Reprod Immunol. 2014; 72(3): 317-25[DOI][PubMed]
  • 16. Steffens JP, Herrera BS, Coimbra LS, Stephens DN, Rossa CJ, Spolidorio LC, et al. Testosterone regulates bone response to inflammation. Horm Metab Res. 2014; 46(3): 193-200[DOI][PubMed]
  • 17. James KC, Nicholls PJ, Roberts M. Biological half-lives of [4-14C]testosterone and some of its esters after injection into the rat. J Pharm Pharmacol. 1969; 21(1): 24-7[PubMed]
  • 18. Moreau MF, Libouban H, Legrand E, Basle MF, Audran M, Chappard D. Lean, fat and bone masses are influenced by orchidectomy in the rat. A densitometric X-ray absorptiometric study. J Musculoskelet Neuronal Interact. 2001; 1(3): 209-13[PubMed]
  • 19. Chin KY, Ima-Nirwana S. The effects of orchidectomy and supraphysiological testosterone administration on trabecular bone structure and gene expression in rats. Aging Male. 2015; 18(1): 60-6[DOI][PubMed]
  • 20. Corcoran MP, Meydani M, Lichtenstein AH, Schaefer EJ, Dillard A, Lamon-Fava S. Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women. J Endocrinol. 2010; 206(2): 217-24[DOI][PubMed]
  • 21. Corrales JJ, Almeida M, Burgo R, Mories MT, Miralles JM, Orfao A. Androgen-replacement therapy depresses the ex vivo production of inflammatory cytokines by circulating antigen-presenting cells in aging type-2 diabetic men with partial androgen deficiency. J Endocrinol. 2006; 189(3): 595-604[DOI][PubMed]
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