Is Hypothyroidism and Hypogonadism an Issue After Aneurysmal Subarachnoid Hemorrhage-An Institutional Experience?

Authors Information
Article Notes and Dates
To Cite : Khursheed N, Ramzan A, Shoaib Y, Bashir I, Wani A, et al. Is Hypothyroidism and Hypogonadism an Issue After Aneurysmal Subarachnoid Hemorrhage-An Institutional Experience?, Int J Endocrinol Metab. 2013 ;11(3):179-183. doi: 10.5812/ijem.8241.
Copyright: Copyright © 2013, International Journal of Endocrinology and Metabolism. .
1. Background
2. Objective
3. Patients and Methods
4. Results
5. Discussion
  • 1. Klose M, Brennum J, Poulsgaard L, Kosteljanetz M, Wagner A, Feldt-Rasmussen U. Hypopituitarism is uncommon after aneurysmal subarachnoid haemorrhage. Clin Endocrinol (Oxf). 2010; 73(1): 95-101[DOI][PubMed]
  • 2. Kreitschmann-Andermahr I, Hoff C, Saller B, Niggemeier S, Pruemper S, Hutter BO, et al. Prevalence of pituitary deficiency in patients after aneurysmal subarachnoid hemorrhage. J Clin Endocrinol Metab. 2004; 89(10): 4986-92[DOI][PubMed]
  • 3. Levitan D, Moser SA, Goldstein DA, Kletzky OA, Lobo RA, Massry SG. Disturbances in the hypothalamic-pituitary-gonadal axis in male patients with acute renal failure. Am J Nephrol. 1984; 4(2): 99-106[PubMed]
  • 4. Matsuura H, Nakazawa S, Wakabayashi I. Thyrotropin-releasing hormone provocative release of prolactin and thyrotropin in acute head injury. Neurosurgery. 1985; 16(6): 791-5[PubMed]
  • 5. Schneider HJ, Kreitschmann-Andermahr I, Ghigo E, Stalla GK, Agha A. Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review. JAMA. 2007; 298(12): 1429-38[DOI][PubMed]
  • 6. Tanriverdi F, Dagli AT, Karaca Z, Unluhizarci K, Selcuklu A, Casanueva FF, et al. High risk of pituitary dysfunction due to aneurysmal subarachnoid haemorrhage: a prospective investigation of anterior pituitary function in the acute phase and 12 months after the event. Clin Endocrinol (Oxf). 2007; 67(6): 931-7[DOI][PubMed]
  • 7. Drake CG. Report of World Federation of Neurological Surgeons Committee on a Universal Subarachnoid Hemorrhage Grading Scale. J Neurosurg. 1988; 68(6): 985-6[PubMed]
  • 8. Fisher CM, Kistler JP, Davis JM. Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery. 1980; 6(1): 1-9[PubMed]
  • 9. Jenkins JS, Buckell M, Carter AB, Westlake S. Hypothalamic-pituitary-adrenal function after subarachnoid haemorrhage. Br Med J. 1969; 4(5685): 707-9[PubMed]
  • 10. Kelly DF, Gonzalo IT, Cohan P, Berman N, Swerdloff R, Wang C. Hypopituitarism following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a preliminary report. J Neurosurg. 2000; 93(5): 743-52[DOI][PubMed]
  • 11. Agha A, Rogers B, Sherlock M, O'Kelly P, Tormey W, Phillips J, et al. Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab. 2004; 89(10): 4929-36[DOI][PubMed]
  • 12. Dimopoulou I, Kouyialis AT, Tzanella M, Armaganidis A, Thalassinos N, Sakas DE, et al. High incidence of neuroendocrine dysfunction in long-term survivors of aneurysmal subarachnoid hemorrhage. Stroke. 2004; 35(12): 2884-9[DOI][PubMed]
  • 13. Ghigo E, Masel B, Aimaretti G, Leon-Carrion J, Casanueva FF, Dominguez-Morales MR, et al. Consensus guidelines on screening for hypopituitarism following traumatic brain injury. Brain Inj. 2005; 19(9): 711-24[DOI][PubMed]
  • 14. Aimaretti G, Ambrosio MR, Di Somma C, Fusco A, Cannavo S, Gasperi M, et al. Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: screening study at 3 months after the brain injury. Clin Endocrinol (Oxf). 2004; 61(3): 320-6[DOI][PubMed]
  • 15. Annane D, Sebille V, Troche G, Raphael JC, Gajdos P, Bellissant E. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA. 2000; 283(8): 1038-45[PubMed]
  • 16. Beishuizen A, Thijs LG, Vermes I. Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma. Intensive Care Med. 2001; 27(10): 1584-91[DOI][PubMed]
  • 17. Bondanelli M, Ambrosio MR, Zatelli MC, De Marinis L, degli Uberti EC. Hypopituitarism after traumatic brain injury. Eur J Endocrinol. 2005; 152(5): 679-91[DOI][PubMed]
  • 18. Hamrahian AH, Oseni TS, Arafah BM. Measurements of serum free cortisol in critically ill patients. N Engl J Med. 2004; 350(16): 1629-38[DOI][PubMed]
  • 19. Spratt DI, Bigos ST, Beitins I, Cox P, Longcope C, Orav J. Both hyper- and hypogonadotropic hypogonadism occur transiently in acute illness: bio- and immunoactive gonadotropins. J Clin Endocrinol Metab. 1992; 75(6): 1562-70[PubMed]
  • 20. Van den Berghe G, de Zegher F, Bouillon R. Clinical review 95: Acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab. 1998; 83(6): 1827-34[PubMed]
  • 21. Chiolero R, Lemarchand T, Schutz Y, de Tribolet N, Felber JP, Freeman J, et al. Plasma pituitary hormone levels in severe trauma with or without head injury. J Trauma. 1988; 28(9): 1368-74[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiaion Alert via Google Reader

Cited By:

International Journal of Endocrinology and Metabolism accepts terms & conditions of:

International Committee of Medical Journal Editors (ICMJE) Citedby Linking DOI enabled Crossref iThenticate COPE Cross Check