Expression and Localization of Neuregulin-1 (Nrg1) and ErbB2/ErbB4 Receptors in Main Endocrine Organs of the Rhesus Monkey

Author Information
Article Notes and Dates
To Cite : Zhao W. Expression and Localization of Neuregulin-1 (Nrg1) and ErbB2/ErbB4 Receptors in Main Endocrine Organs of the Rhesus Monkey, Int J Endocrinol Metab. 2013 ;11(3):162-166. doi: 10.5812/ijem.9871.
Copyright: Copyright © 2013, International Journal of Endocrinology and Metabolism. .
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Ritch PS, Carroll SL, Sontheimer H. Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia. 2005; 51(3): 217-28[DOI][PubMed]
  • 2. Mei L, Xiong WC. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci. 2008; 9(6): 437-52[DOI][PubMed]
  • 3. Wilson TR, Lee DY, Berry L, Shames DS, Settleman J. Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers. Cancer Cell. 2011; 20(2): 158-72[DOI][PubMed]
  • 4. Zhao W, Ren SG. Neuregulin-1 (Nrg1) is mainly expressed in rat pituitary gonadotroph cells and possibly regulates prolactin (PRL) secretion in a juxtacrine manner. J Neuroendocrinol. 2011; 23(12): 1252-62[DOI][PubMed]
  • 5. Zhao W, Shen Y, Ren S. Endogenous expression of Neuregulin-1 (Nrg1) as a potential modulator of prolactin (PRL) secretion in GH3 cells. Cell Tissue Res. 2011; 344(2): 313-20[DOI][PubMed]
  • 6. Zhao WJ, Ren SG. [Endogenous neuregulin-1 expression in the anterior pituitary of female Wistar-Furth rats during the estrous cycle]. Nan Fang Yi Ke Da Xue Xue Bao. 2011; 31(6): 921-7[PubMed]
  • 7. Bernstein HG, Lendeckel U, Bertram I, Bukowska A, Kanakis D, Dobrowolny H, et al. Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain. Brain Res Bull. 2006; 69(5): 546-59[DOI][PubMed]
  • 8. Prevot V, Rio C, Cho GJ, Lomniczi A, Heger S, Neville CM, et al. Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes. J Neurosci. 2003; 23(1): 230-9[PubMed]
  • 9. Vlotides G, Cooper O, Chen YH, Ren SG, Greenman Y, Melmed S. Heregulin regulates prolactinoma gene expression. Cancer Res. 2009; 69(10): 4209-16[DOI][PubMed]
  • 10. Thompson M, Lauderdale S, Webster MJ, Chong VZ, McClintock B, Saunders R, et al. Widespread expression of ErbB2, ErbB3 and ErbB4 in non-human primate brain. Brain Res. 2007; 1139: 95-109[DOI][PubMed]
  • 11. Li J, Qiang O, Wang L. [Effects of neuregulin on cardiac myocyte apoptosis and PI-3K signal transduction pathway in rapid pacing-induced heart failure in rhesus monkeys]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007; 32(3): 408-12[PubMed]
  • 12. Tang H, Huang H, Zhang Y, Chen J, Zhao Y, Wang L. [Effects of recombined neuregulin on healthy Macaca mulatta hearts]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008; 25(1): 154-6[PubMed]
  • 13. Zhang R, Li Q, Wang T, Du F, Guo YL. [Interfering effect of neuregulin upon cerebral ischemic reperfusion injury in rhesus monkeys]. Zhonghua Yi Xue Za Zhi. 2009; 89(19): 1361-4[PubMed]
  • 14. Sworczak K, Zaczek A, Babinska A, Lisowska U, Bielawski KP, Falkiewicz B. Gene copy numbers of erbB oncogenes in human pheochromocytoma. Oncol Rep. 2002; 9(6): 1373-8[PubMed]
  • 15. Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC. Neuregulin-4: a novel growth factor that acts through the ErbB4 receptor tyrosine kinase. Oncogene. 1999; 18(17): 2681-9
  • 16. Huotari MA, Miettinen PJ, Palgi J, Koivisto T, Ustinov J, Harari D, et al. ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture. Endocrinology. 2002; 143(11): 4437-46[PubMed]
  • 17. Huotari MA, Palgi J, Otonkoski T. Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen. Endocrinology. 1998; 139(4): 1494-9[PubMed]
  • 18. Graber Hans U, Friess Helmut, Kaufmann Brigitte, Willi Doris, Zimmermann Arthur, Korc Murray, et al. ErbB‐4 mRNA expression is decreased in non‐metastatic pancreatic cancer. Int J Cancer. 1999; 84(1): 24-27
  • 19. O'Shea S, Johnson K, Clark R, Sliwkowski MX, Erickson SL. Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy. Am J Pathol. 2001; 158(5): 1871-80[PubMed]
  • 20. Kritzik MR, Krahl T, Good A, Gu D, Lai C, Fox H, et al. Expression of ErbB receptors during pancreatic islet development and regrowth. J Endocrinol. 2000; 165(1): 67-77[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Cited By:

International Journal of Endocrinology and Metabolism accepts terms & conditions of:

International Committee of Medical Journal Editors (ICMJE) Citedby Linking DOI enabled Crossref iThenticate COPE Cross Check