Effect of Extremely Low Frequency Electromagnetic Field and GABAA Receptors on Serum Testosterone Level of Male Rats

Authors Information
Article Notes and Dates
To Cite : Taherianfard M, Bahaddini A, Keshtkar S, Fazeli M, Shomali T. et al. Effect of Extremely Low Frequency Electromagnetic Field and GABAA Receptors on Serum Testosterone Level of Male Rats, Int J Endocrinol Metab. 2013 ;11(4):e11029. doi: 10.5812/ijem.11029.
Copyright: Copyright © 2013, International Journal of Endocrinology and Metabolism. .
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Gamel-Didelon K, Corsi C, Pepeu G, Jung H, Gratzl M, Mayerhofer A. An autocrine role for pituitary GABA: activation of GABA-B receptors and regulation of growth hormone levels. Neuroendocrinology. 2002; 76(3): 170-7[PubMed]
  • 2. Gamel-Didelon K, Kunz L, Fohr KJ, Gratzl M, Mayerhofer A. Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells. J Biol Chem. 2003; 278(22): 20192-5[DOI][PubMed]
  • 3. Mayerhofer A, Hohne-Zell B, Gamel-Didelon K, Jung H, Redecker P, Grube D, et al. Gamma-aminobutyric acid (GABA): a para- and/or autocrine hormone in the pituitary. FASEB J. 2001; 15(6): 1089-91[PubMed]
  • 4. Gilon P, Bertrand G, Loubatieres-Mariani MM, Remacle C, Henquin JC. The influence of gamma-aminobutyric acid on hormone release by the mouse and rat endocrine pancreas. Endocrinology. 1991; 129(5): 2521-9[PubMed]
  • 5. Rorsman P, Berggren PO, Bokvist K, Ericson H, Mohler H, Ostenson CG, et al. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature. 1989; 341(6239): 233-6[DOI][PubMed]
  • 6. Satin LS, Kinard TA. Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit? Endocrine. 1998; 8(3): 213-23[DOI][PubMed]
  • 7. Ritta MN, Campos MB, Calandra RS. Coexistence of gamma-aminobutyric acid type A and type B receptors in testicular interstitial cells. J Neurochem. 1991; 56(4): 1236-40[PubMed]
  • 8. Geigerseder C, Doepner R, Thalhammer A, Frungieri MB, Gamel-Didelon K, Calandra RS, et al. Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors. Neuroendocrinology. 2003; 77(5): 314-23[PubMed]
  • 9. Naumenko EV, Zhukova AV, Serova LI. Participation of gamma-aminobutyric acid in the negative feedback mechanisms of the hypothalamohypophyseotesticular complex. Neurosci Behav Physiol. 1996; 26(2): 133-6[PubMed]
  • 10. Karasek M, Woldanska-Okonska M. Electromagnetic fields and human endocrine system. ScientificWorldJournal. 2004; 4 Suppl 2: 23-8[DOI][PubMed]
  • 11. Kato M, Honma K, Shigemitsu T, Shiga Y. Circularly polarized, sinusoidal, 50 Hz magnetic field exposure does not influence plasma testosterone levels of rats. Bioelectromagnetics. 1994; 15(6): 513-8[PubMed]
  • 12. Margonato V, Veicsteinas A, Conti R, Nicolini P, Cerretelli P. Biologic effects of prolonged exposure to ELF electromagnetic fields in rats. I. 50 Hz electric fields. Bioelectromagnetics. 1993; 14(5): 479-93[PubMed]
  • 13. Marino AA, Wolcott RM, Chervenak R, Jourd'heuil F, Nilsen E, Frilot C, 2nd, et al. Coincident nonlinear changes in the endocrine and immune systems due to low-frequency magnetic fields. Neuroimmunomodulation. 2001; 9(2): 65-77[PubMed]
  • 14. Mostafa RM, Moustafa YM, Ali FM, Shafik A. Sex hormone status in male rats after exposure to 50 Hz, 5 mTesla magnetic field. Arch Androl. 2006; 52(5): 363-9[DOI][PubMed]
  • 15. de Bruyn L, de Jager L. Effect of long-term exposure to a randomly varied 50 Hz power frequency magnetic field on the fertility of the mouse. Electromagn Biol Med. 2010; 29(1-2): 52-61[DOI][PubMed]
  • 16. Kim YW, Kim HS, Lee JS, Kim YJ, Lee SK, Seo JN, et al. Effects of 60 Hz 14 microT magnetic field on the apoptosis of testicular germ cell in mice. Bioelectromagnetics. 2009; 30(1): 66-72[DOI][PubMed]
  • 17. Al-Akhras MA, Darmani H, Elbetieha A. Influence of 50 Hz magnetic field on sex hormones and other fertility parameters of adult male rats. Bioelectromagnetics. 2006; 27(2): 127-31[DOI][PubMed]
  • 18. Mostafa RM, El Hefnawi AL, Moustafa KM, Ali FM, Moustafa YM, Kamal S, et al. Effect of 50 Hz, 10 mTesla magnetic field on sex hormones level in male rats. J Med Sci Res. 2007; 1: 31-36
  • 19. Farkhad SA, Zare S, Hayatgeibi H, Qadiri A. Effects of extremely low frequency electromagnetic fields on testes in guinea pig. Pak J Biol Sci. 2007; 10(24): 4519-22[PubMed]
  • 20. Ochi R, Suemaru K, Watanabe S, Yamaguchi T, Takechi K, Kawasaki H, et al. Effect of heat exposure on aminophylline-induced convulsions in mice. Biol Pharm Bull. 2011; 34(5): 666-70[PubMed]
  • 21. Zarrindast MR, Ghadimi M, Ramezani-Tehrani B, Sahebgharani M. Effect of GABA receptor agonists or antagonists on morphine-induced Straub tail in mice. Int J Neurosci. 2006; 116(8): 963-73[DOI][PubMed]
  • 22. Eleuteri AM, Amici M, Bonfili L, Cecarini V, Cuccioloni M, Grimaldi S, et al. 50Hz Extremely Low Frequency Electromagnetic Fields Enhance Protein Carbonyl Groups Content in Cancer Cells: Effects on Proteasomal Systems. J Biomed Biotechnol. 2009; 2009[DOI]
  • 23. Amikishieva AV. Testosterone and behavior: involvement of the hormone in psychotropic effects of baclofen. Bull Exp Biol Med. 2007; 143(2): 259-63[PubMed]
  • 24. Taherianfard M, Ahmadi G. Role of GABAergic system on serum testosterone and K+ in male rat. J School Vet Med Shahid Chamran Univ. 2003; 8: 35-44
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiaion Alert via Google Reader

Cited By:

International Journal of Endocrinology and Metabolism accepts terms & conditions of:

International Committee of Medical Journal Editors (ICMJE) Citedby Linking DOI enabled Crossref iThenticate COPE Cross Check