Interactions of Morphine and Peptide 234 on Mean Plasma Testosterone Concentration

Authors Information
Article Notes and Dates
To Cite : Mahmoudi F, Khazali H, Janahmadi M. Interactions of Morphine and Peptide 234 on Mean Plasma Testosterone Concentration, Int J Endocrinol Metab. 2014 ;12(1):e12554. doi: 10.5812/ijem.12554.
Copyright: Copyright © 2014, International Journal of Endocrinology and Metabolism. .
Abstract
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Ceccarelli I, De Padova AM, Fiorenzani P, Massafra C, Aloisi AM. Single opioid administration modifies gonadal steroids in both the CNS and plasma of male rats. Neuroscience. 2006; 140(3): 929-37[DOI][PubMed]
  • 2. Fayez M, Ahmed HH, el Nabarawy F, Shokery IM, el-Bauomy AM. Effects of butorphanol on luteinizing hormone and follicle stimulating hormone levels in ovariectomized rats--comparative study with morphine sulphate. Arch Exp Veterinarmed. 1991; 45(1): 101-3[PubMed]
  • 3. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010; 31(1): 98-132[DOI][PubMed]
  • 4. Anandalaxmi P, Vijayan E. Effects of postnatal treatment with naloxone on plasma gonadotropin, prolactin, testosterone and testicular functions in male rats. J Biosci. 1989; 14(4): 391-398[DOI]
  • 5. He Deqin, Mitsushima Dai, Uemura Tsuguo, Hirahara Fumiki, Funabashi Toshiya, Shinohara Kazuyuki, et al. Effects of naloxone on the serum luteinizing hormone level and the number of Fos-positive gonadotropin-releasing hormone neurons in immature female rats. Brain Research. 2000; 858(1): 129-135[DOI]
  • 6. Limonta Patrizia, Wayne Bardin C, Hahn Elliot F, Thau Rosemarie B. Unexpected effects of nalmefene, a new opiate antagonist, on the hypothalamic-pituitary-gonadal axis in the male rat. Steroids. 1985; 46(6): 955-965[DOI]
  • 7. Pfeiffer DG, Pfeiffer A, Shimohigashi Y, Merriam GR, Loriaux DL. Predominant involvement of mu- rather than delta- or kappa-opiate receptors in LH secretion. Peptides. 1983; 4(5): 647-649[DOI]
  • 8. Rajagopal Arun, Vassilopoulou-Sellin Rena, Palmer JLynn, Kaur Guddi, Bruera Eduardo. Hypogonadism and sexual dysfunction in male cancer survivors receiving chronic opioid therapy. Journal of Pain and Symptom Management. 2003; 26(5): 1055-1061[DOI]
  • 9. Rajagopal A, Vassilopoulou-Sellin R, Palmer JL, Kaur G, Bruera E. Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer. 2004; 100(4): 851-8[DOI][PubMed]
  • 10. Shacoori V, Guerin J, Girre A, Saïag B, Rault B. Effect of naloxone and β-casomorphin on the hypothalamic-pituitary-luteinizing hormone axis in vitro. Life Sciences. 1992; 51(12): 899-907[DOI]
  • 11. Walsh JP, Clarke IJ. Effects of central administration of highly selective opioid mu-, delta- and kappa-receptor agonists on plasma luteinizing hormone (LH), prolactin, and the estrogen-induced LH surge in ovariectomized ewes. Endocrinology. 1996; 137(9): 3640-8[DOI][PubMed]
  • 12. Navarro VM, Castellano JM, Fernandez-Fernandez R, Tovar S, Roa J, Mayen A, et al. Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology. 2005; 146(1): 156-63[DOI][PubMed]
  • 13. d'Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, et al. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A. 2007; 104(25): 10714-9[DOI][PubMed]
  • 14. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A. 2003; 100(19): 10972-6[DOI][PubMed]
  • 15. Li XF, Kinsey-Jones JS, Cheng Y, Knox AM, Lin Y, Petrou NA, et al. Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One. 2009; 4(12)[DOI][PubMed]
  • 16. Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, et al. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci. 2009; 29(12): 3920-9[DOI][PubMed]
  • 17. Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci. 2009; 29(38): 11859-66[DOI][PubMed]
  • 18. Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, et al. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci. 2010; 30(8): 3124-32[DOI][PubMed]
  • 19. Kalra SP, Kalra PS. Opioid-adrenergic-steroid connection in regulation of luteinizing hormone secretion in the rat. Neuroendocrinology. 1984; 38(5): 418-26[PubMed]
  • 20. Kaur G, Kaur G. Role of cholinergic and GABAergic neurotransmission in the opioids-mediated GnRH release mechanism of EBP-primed OVX rats. Mol Cell Biochem. 2001; 219(1-2): 13-9[PubMed]
  • 21. Lewis MJ, Johnson DF, Waldman D, Leibowitz SF, Hoebel BG. Galanin microinjection in the third ventricle increases voluntary ethanol intake. Alcohol Clin Exp Res. 2004; 28(12): 1822-8[PubMed]
  • 22. Patterson M, Murphy KG, Thompson EL, Patel S, Ghatei MA, Bloom SR. Administration of kisspeptin-54 into discrete regions of the hypothalamus potently increases plasma luteinising hormone and testosterone in male adult rats. J Neuroendocrinol. 2006; 18(5): 349-54[DOI][PubMed]
  • 23. Thompson EL, Amber V, Stamp GW, Patterson M, Curtis AE, Cooke JH, et al. Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms. Br J Pharmacol. 2009; 156(4): 609-25[DOI][PubMed]
  • 24. Castellano JM, Navarro VM, Fernandez-Fernandez R, Nogueiras R, Tovar S, Roa J, et al. Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology. 2005; 146(9): 3917-25[DOI][PubMed]
  • 25. Forbes S, Li XF, Kinsey-Jones J, O'Byrne K. Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat. Neurosci Lett. 2009; 460(2): 143-7[DOI][PubMed]
  • 26. Saied Salehi M, Jafarzadeh Shirazi MR, Zamiri MJ, Pazhoohi F, Namavar MR. Hypothalamic expression of KiSS1 and RFamide-related peptide-3 mRNAs during the estrous cycle of rats. IJFS. 2013; 6(4): 304-9
  • 27. Smith JT, Clay CM, Caraty A, Clarke IJ. KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology. 2007; 148(3): 1150-7[DOI][PubMed]
  • 28. Smith JT, Acohido BV, Clifton DK, Steiner RA. KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol. 2006; 18(4): 298-303[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiaion Alert via Google Reader

Cited By:

International Journal of Endocrinology and Metabolism accepts terms & conditions of:

International Committee of Medical Journal Editors (ICMJE) Citedby Linking DOI enabled Crossref iThenticate COPE Cross Check