International Journal of Endocrinology and Metabolism

Published by: Kowsar

Interactions of Morphine and Peptide 234 on Mean Plasma Testosterone Concentration

Fariba Mahmoudi 1 , Homayoun Khazali 1 , * and Mahyar Janahmadi 2
Authors Information
1 Department of Animal Sciences,Faculty of Biological Sciences, Shahid Beheshti University, Tehran, IR Iran
2 Department of Phsiology Neurophysiology Research Center, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • International Journal of Endocrinology and Metabolism: January 01, 2014, 12 (1); e12554
  • Published Online: January 1, 2014
  • Article Type: Research Article
  • Received: May 30, 2013
  • Revised: August 7, 2013
  • Accepted: August 19, 2013
  • DOI: 10.5812/ijem.12554

To Cite: Mahmoudi F, Khazali H, Janahmadi M. Interactions of Morphine and Peptide 234 on Mean Plasma Testosterone Concentration, Int J Endocrinol Metab. 2014 ;12(1):e12554. doi: 10.5812/ijem.12554.

Abstract
Copyright © 2014, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Ceccarelli I, De Padova AM, Fiorenzani P, Massafra C, Aloisi AM. Single opioid administration modifies gonadal steroids in both the CNS and plasma of male rats. Neuroscience. 2006; 140(3): 929-37[DOI][PubMed]
  • 2. Fayez M, Ahmed HH, el Nabarawy F, Shokery IM, el-Bauomy AM. Effects of butorphanol on luteinizing hormone and follicle stimulating hormone levels in ovariectomized rats--comparative study with morphine sulphate. Arch Exp Veterinarmed. 1991; 45(1): 101-3[PubMed]
  • 3. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010; 31(1): 98-132[DOI][PubMed]
  • 4. Anandalaxmi P, Vijayan E. Effects of postnatal treatment with naloxone on plasma gonadotropin, prolactin, testosterone and testicular functions in male rats. J Biosci. 1989; 14(4): 391-398[DOI]
  • 5. He Deqin, Mitsushima Dai, Uemura Tsuguo, Hirahara Fumiki, Funabashi Toshiya, Shinohara Kazuyuki, et al. Effects of naloxone on the serum luteinizing hormone level and the number of Fos-positive gonadotropin-releasing hormone neurons in immature female rats. Brain Research. 2000; 858(1): 129-135[DOI]
  • 6. Limonta Patrizia, Wayne Bardin C, Hahn Elliot F, Thau Rosemarie B. Unexpected effects of nalmefene, a new opiate antagonist, on the hypothalamic-pituitary-gonadal axis in the male rat. Steroids. 1985; 46(6): 955-965[DOI]
  • 7. Pfeiffer DG, Pfeiffer A, Shimohigashi Y, Merriam GR, Loriaux DL. Predominant involvement of mu- rather than delta- or kappa-opiate receptors in LH secretion. Peptides. 1983; 4(5): 647-649[DOI]
  • 8. Rajagopal Arun, Vassilopoulou-Sellin Rena, Palmer JLynn, Kaur Guddi, Bruera Eduardo. Hypogonadism and sexual dysfunction in male cancer survivors receiving chronic opioid therapy. Journal of Pain and Symptom Management. 2003; 26(5): 1055-1061[DOI]
  • 9. Rajagopal A, Vassilopoulou-Sellin R, Palmer JL, Kaur G, Bruera E. Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer. 2004; 100(4): 851-8[DOI][PubMed]
  • 10. Shacoori V, Guerin J, Girre A, Saïag B, Rault B. Effect of naloxone and β-casomorphin on the hypothalamic-pituitary-luteinizing hormone axis in vitro. Life Sciences. 1992; 51(12): 899-907[DOI]
  • 11. Walsh JP, Clarke IJ. Effects of central administration of highly selective opioid mu-, delta- and kappa-receptor agonists on plasma luteinizing hormone (LH), prolactin, and the estrogen-induced LH surge in ovariectomized ewes. Endocrinology. 1996; 137(9): 3640-8[DOI][PubMed]
  • 12. Navarro VM, Castellano JM, Fernandez-Fernandez R, Tovar S, Roa J, Mayen A, et al. Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology. 2005; 146(1): 156-63[DOI][PubMed]
  • 13. d'Anglemont de Tassigny X, Fagg LA, Dixon JP, Day K, Leitch HG, Hendrick AG, et al. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A. 2007; 104(25): 10714-9[DOI][PubMed]
  • 14. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A. 2003; 100(19): 10972-6[DOI][PubMed]
  • 15. Li XF, Kinsey-Jones JS, Cheng Y, Knox AM, Lin Y, Petrou NA, et al. Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One. 2009; 4(12)[DOI][PubMed]
  • 16. Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, et al. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci. 2009; 29(12): 3920-9[DOI][PubMed]
  • 17. Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci. 2009; 29(38): 11859-66[DOI][PubMed]
  • 18. Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, et al. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci. 2010; 30(8): 3124-32[DOI][PubMed]
  • 19. Kalra SP, Kalra PS. Opioid-adrenergic-steroid connection in regulation of luteinizing hormone secretion in the rat. Neuroendocrinology. 1984; 38(5): 418-26[PubMed]
  • 20. Kaur G, Kaur G. Role of cholinergic and GABAergic neurotransmission in the opioids-mediated GnRH release mechanism of EBP-primed OVX rats. Mol Cell Biochem. 2001; 219(1-2): 13-9[PubMed]
  • 21. Lewis MJ, Johnson DF, Waldman D, Leibowitz SF, Hoebel BG. Galanin microinjection in the third ventricle increases voluntary ethanol intake. Alcohol Clin Exp Res. 2004; 28(12): 1822-8[PubMed]
  • 22. Patterson M, Murphy KG, Thompson EL, Patel S, Ghatei MA, Bloom SR. Administration of kisspeptin-54 into discrete regions of the hypothalamus potently increases plasma luteinising hormone and testosterone in male adult rats. J Neuroendocrinol. 2006; 18(5): 349-54[DOI][PubMed]
  • 23. Thompson EL, Amber V, Stamp GW, Patterson M, Curtis AE, Cooke JH, et al. Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms. Br J Pharmacol. 2009; 156(4): 609-25[DOI][PubMed]
  • 24. Castellano JM, Navarro VM, Fernandez-Fernandez R, Nogueiras R, Tovar S, Roa J, et al. Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology. 2005; 146(9): 3917-25[DOI][PubMed]
  • 25. Forbes S, Li XF, Kinsey-Jones J, O'Byrne K. Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat. Neurosci Lett. 2009; 460(2): 143-7[DOI][PubMed]
  • 26. Saied Salehi M, Jafarzadeh Shirazi MR, Zamiri MJ, Pazhoohi F, Namavar MR. Hypothalamic expression of KiSS1 and RFamide-related peptide-3 mRNAs during the estrous cycle of rats. IJFS. 2013; 6(4): 304-9
  • 27. Smith JT, Clay CM, Caraty A, Clarke IJ. KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology. 2007; 148(3): 1150-7[DOI][PubMed]
  • 28. Smith JT, Acohido BV, Clifton DK, Steiner RA. KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol. 2006; 18(4): 298-303[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments