International Journal of Endocrinology and Metabolism

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Gender Differences in Risk Factors of Congenital Hypothyroidism: An Interaction Hypothesis Examination

Shahab Rezaeian 1 , Abbas Moghimbeigi 2 and Nader Esmailnasab 3 , *
Authors Information
1 Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Research Center for Health Sciences, Department of Epidemiology and Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, IR Iran
3 Kurdistan Research Center for Social Determinants of Health (KRCSDH), School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IR Iran
Article information
  • International Journal of Endocrinology and Metabolism: April 01, 2014, 12 (2); e13946
  • Published Online: April 1, 2014
  • Article Type: Research Article
  • Received: July 31, 2013
  • Revised: August 12, 2013
  • Accepted: January 5, 2014
  • DOI: 10.5812/ijem.13946

To Cite: Rezaeian S, Moghimbeigi A, Esmailnasab N. Gender Differences in Risk Factors of Congenital Hypothyroidism: An Interaction Hypothesis Examination, Int J Endocrinol Metab. 2014 ; 12(2):e13946. doi: 10.5812/ijem.13946.

Copyright © 2014, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 2010; 5: 17[DOI][PubMed]
  • 2. Gruters A, Biebermann H, Krude H. Neonatal thyroid disorders. Horm Res. 2003; 59 Suppl 1: 24-9[PubMed]
  • 3. Delavari A, Yar Ahmadi S, Ordookhani A, Noroozi Nejad A, Mahdavi A, Safaee A, et al. Screening program of neonatal congenital hypothyroidism and transient TSH level incresase in iran. Ministry of Health and Medical Education of Iran. 2005;
  • 4. Hashemipour M, Amini M, Iranpour R, Sadri GH, Javaheri N, Haghighi S, et al. Prevalence of congenital hypothyroidism in Isfahan, Iran: results of a survey on 20,000 neonates. Horm Res. 2004; 62(2): 79-83[DOI][PubMed]
  • 5. Karamizadeh Z, Dalili S, Sanei-Far H, Karamifard H, Mohammadi H, Amirhakimi G. Does congenital hypothyroidism have different etiologies in iran? Iran J Pediatr. 2011; 21(2): 188-92[PubMed]
  • 6. Zeinalzadeh AH, Talebi M. Neonatal screening for congenital hypothyroidism in East Azerbaijan, Iran: the first report. J Med Screen. 2012; 19(3): 123-6[DOI][PubMed]
  • 7. Beardsall K, Ogilvy-Stuart AL. Congenital hypothyroidism. Current Paediatrics. 2004; 14(5): 422-9
  • 8. Abdelmoktader AM. Risk factors for congenital hypothyroidism in Egypt: results of a population case-control study (2003-2010). Ann Saudi Med. 2013; 33(3): 273-6[DOI][PubMed]
  • 9. Mao HQ, Yang RL, Liu ZH. [Correlation of congenital hypothyroidism with birth weight and gestational age in newborn infants]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007; 36(4): 378-81[PubMed]
  • 10. Hinton CF, Harris KB, Borgfeld L, Drummond-Borg M, Eaton R, Lorey F, et al. Trends in incidence rates of congenital hypothyroidism related to select demographic factors: data from the United States, California, Massachusetts, New York, and Texas. Pediatrics. 2010; 125 Suppl 2-47[DOI][PubMed]
  • 11. Medda E, Olivieri A, Stazi MA, Grandolfo ME, Fazzini C, Baserga M, et al. Risk factors for congenital hypothyroidism: results of a population case-control study (1997-2003). Eur J Endocrinol. 2005; 153(6): 765-73[DOI][PubMed]
  • 12. Ordookhani A, Mirmiran P, Moharamzadeh M, Hedayati M, Azizi F. A high prevalence of consanguineous and severe congenital hypothyroidism in an Iranian population. J Pediatr Endocrinol Metab. 2004; 17(9): 1201-9[PubMed]
  • 13. Connelly JF, Rickards AL, Coakley JC, Price GJ, Francis I, Mathur KS, et al. Newborn screening for congenital hypothyroidism, Victoria, Australia, 1977-1997. Part 2: Treatment, progress and outcome. J Pediatr Endocrinol Metab. 2001; 14(9): 1611-34[PubMed]
  • 14. McElduff A, McElduff P, Wiley V, Wilcken B. Neonatal thyrotropin as measured in a congenital hypothyroidism screening program: influence of the mode of delivery. J Clin Endocrinol Metab. 2005; 90(12): 6361-3[DOI][PubMed]
  • 15. Van Vliet G, Larroque B, Bubuteishvili L, Supernant K, Leger J. Sex-specific impact of congenital hypothyroidism due to thyroid dysgenesis on skeletal maturation in term newborns. J Clin Endocrinol Metab. 2003; 88(5): 2009-13[DOI][PubMed]
  • 16. Hashemipour M, Amini M, Kelishadi R, Hovsepian S, Haghighi S, Hosseini M, et al. Seasonal variation in the incidence of congenital hypothyroidism in Isfahan, Iran. Saudi Med J. 2007; 28(10): 1582-6[PubMed]
  • 17. Ordookhani A, Padyab M, Goldasteh A, Mirmiran P, Richter J, Azizi F. Seasonal variation of neonatal transient hyperthyrotropinemia in Tehran province, 1998-2005. Chronobiol Int. 2010; 27(9-10): 1854-69[DOI][PubMed]
  • 18. Kautzky-Willer A. Sex and gender aspects in clinical medicine. 2011; : 125-49
  • 19. Parks JS, Lin M, Grosse SD, Hinton CF, Drummond-Borg M, Borgfeld L, et al. The impact of transient hypothyroidism on the increasing rate of congenital hypothyroidism in the United States. Pediatrics. 2010; 125 Suppl 2-63[DOI][PubMed]
  • 20. Ng SM, Wong SC, Isherwood DM, Didi M. Biochemical severity of thyroid ectopia in congenital hypothyroidism demonstrates sexual dimorphism. Eur J Endocrinol. 2007; 156(1): 49-53[DOI][PubMed]
  • 21. Eugene D, Djemli A, Van Vliet G. Sexual dimorphism of thyroid function in newborns with congenital hypothyroidism. J Clin Endocrinol Metab. 2005; 90(5): 2696-700[DOI][PubMed]
  • 22. Rezaeian S, Poorolajal J, Moghimbegi A, Esmailnasab N. Risk factors of congenital hypothyroidism using propensity score: a matched case-control study. J Res Health Sci. 2013; 13(2): 151-6[PubMed]
  • 23. Iron Deficiency Anaemia: Assessment, Prevention, and Control : a Guide for Programme Managers. 2001;
  • 24. Ordoukhani A, Mirmiran P, Mehrabi Y, Azizi F, Moharamzadeh M, Hedayati M. Seasonal variation of hypothyroidism and recall rate in neonates. Iran J Endocrinol Metab. 2003; 4(4): 243-7
  • 25. Gu YH, Kato T, Harada S, Inomata H, Saito T, Aoki K. Seasonality in the incidence of congenital hypothyroidism in Japan: gender-specific patterns and correlation with temperature. Thyroid. 2007; 17(9): 869-74[DOI][PubMed]
  • 26. Hall SK, Hutchesson AC, Kirk JM. Congenital hypothyroidism, seasonality and consanguinity in the West Midlands, England. Acta Paediatr. 1999; 88(2): 212-5[PubMed]
  • 27. Pearce MS, Korada M, Day J, Turner S, Allison D, Kibirige M, et al. Increasing Incidence, but Lack of Seasonality, of Elevated TSH Levels, on Newborn Screening, in the North of England. J Thyroid Res. 2010; 2010: 101948[DOI][PubMed]
  • 28. Rocchi MB, Perlini C, Ciatti R, Burroni M. Is the birthdate a risk factor for congenital hypothyroidism? A statistical answer based on personal experience. Minerva Pediatr. 2001; 53(6): 531-6[PubMed]
  • 29. Deladoey J, Belanger N, Van Vliet G. Random variability in congenital hypothyroidism from thyroid dysgenesis over 16 years in Quebec. J Clin Endocrinol Metab. 2007; 92(8): 3158-61[DOI][PubMed]
  • 30. Plut C, Ribiere C, Giudicelli Y, Dausse JP. Gender differences in hypothalamic tyrosine hydroxylase and alpha(2)-adrenoceptor subtype gene expression in cafeteria diet-induced hypertension and consequences of neonatal androgenization. J Pharmacol Exp Ther. 2002; 302(2): 525-31[DOI][PubMed]
  • 31. Castanet M, Polak M, Bonaiti-Pellie C, Lyonnet S, Czernichow P, Leger J. Nineteen years of national screening for congenital hypothyroidism: familial cases with thyroid dysgenesis suggest the involvement of genetic factors. J Clin Endocrinol Metab. 2001; 86(5): 2009-14[DOI][PubMed]
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