Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature

Authors Information
Article Notes and Dates
To Cite : Rokni H, Sadeghi R, Moossavi Z, Treglia G, Zakavi S R. et al. Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature, Int J Endocrinol Metab. 2013 ;12(2):e14424. doi: 10.5812/ijem.14424.
Copyright: Copyright © 2013, International Journal of Endocrinology and Metabolism. .
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Reiners C, Schneider P. Radioiodine therapy of thyroid autonomy. Eur J Nucl Med Mol Imaging. 2002; 29 Suppl 2-8[DOI][PubMed]
  • 2. Vaidya B, Williams GR, Abraham P, Pearce SH. Radioiodine treatment for benign thyroid disorders: results of a nationwide survey of UK endocrinologists. Clin Endocrinol (Oxf). 2008; 68(5): 814-20[DOI][PubMed]
  • 3. Huysmans DA, Corstens FH, Kloppenborg PW. Long-term follow-up in toxic solitary autonomous thyroid nodules treated with radioactive iodine. J Nucl Med. 1991; 32(1): 27-30[PubMed]
  • 4. Jarlov AE, Hegedus L, Kristensen LO, Nygaard B, Hansen JM. Is calculation of the dose in radioiodine therapy of hyperthyroidism worth while? Clin Endocrinol (Oxf). 1995; 43(3): 325-9[PubMed]
  • 5. Zakavi SR, Mousavi Z, Davachi B. Comparison of four different protocols of I-131 therapy for treating single toxic thyroid nodule. Nucl Med Commun. 2009; 30(2): 169-75[DOI][PubMed]
  • 6. Abos MD, Banzo J, Razola P, Garcia F, Prats E. [131I-treatment of the autonomous toxic nodule. Assessment of a fixed dose protocol]. Rev Esp Med Nucl. 1999; 18(6): 431-5[PubMed]
  • 7. Beckers C. 131I therapy of toxic and non-toxic goiters. Q J Nucl Med. 1999; 43(4): 291-6[PubMed]
  • 8. Bertelsen J, Herskind AM, Sprogoe Jakobsen U, Hegedus L. Is standard 555 MBq 131I-therapy of hyperthyroidism ablative? Thyroidology. 1992; 4(3): 103-6[PubMed]
  • 9. Tzavara I, Tzanela M, Vlassopoulou B, Kouyioumoutzakis G, Kyriazopoulou V, Alevizaki C, et al. Long term thyroid function after (131)I treatment for toxic adenoma. Hormones (Athens). 2002; 1(2): 99-103[PubMed]
  • 10. Sisson JC, Avram AM, Rubello D, Gross MD. Radioiodine treatment of hyperthyroidism: fixed or calculated doses; intelligent design or science? Eur J Nucl Med Mol Imaging. 2007; 34(7): 1129-30[DOI][PubMed]
  • 11. de Rooij A, Vandenbroucke JP, Smit JW, Stokkel MP, Dekkers OM. Clinical outcomes after estimated versus calculated activity of radioiodine for the treatment of hyperthyroidism: systematic review and meta-analysis. Eur J Endocrinol. 2009; 161(5): 771-7[DOI][PubMed]
  • 12. Sonmez B, Erem C, Dogan I, Ersoz HO, Sonmez M. Efficacy of low and high fixed dose radioactive iodine therapy in patients with toxic nodular goiter. Minerva Endocrinol. 2011; 36(2): 117-21[PubMed]
  • 13. Huysmans DA, Hermus AR, Corstens FH, Kloppenborg PW. Long-term results of two schedules of radioiodine treatment for toxic multinodular goitre. Eur J Nucl Med. 1993; 20(11): 1056-62[PubMed]
  • 14. Khanna CM, Magdum M, Ravishankar L, Dham DN, Chugh P. Evaluation of long-term results of two schedules of treatment for toxic multinodular goitre with radioiodine therapy (I 131). J Assoc Physicians India. 1996; 44(2): 102-5[PubMed]
  • 15. Kok SW, Smit JW, de Craen AJ, Goslings BM, van Eck-Smit BL, Romijn JA. Clinical outcome after standardized versus dosimetric radioiodine treatment of hyperthyroidism: an equivalence study. Nucl Med Commun. 2000; 21(11): 1071-8[PubMed]
  • 16. Ustun F, Yuksel M, Durmus-Altun G, Kaya M, Cermik TF, Sarikaya A, et al. The incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991-2003. Ann Nucl Med. 2005; 19(8): 737-42[PubMed]
  • 17. Thientunyakit T, Thongmak S, Premprapha T. Comparative evaluation of two different dosage calculation protocols of iodine-131 in the treatment of hyperthyroidism. J Med Assoc Thai. 2010; 93(8): 969-77[PubMed]
  • 18. Traino AC, Grosso M, Mariani G. Possibility of limiting the un-justified irradiation in (131)I therapy of Graves' disease: a thyroid mass-reduction based method for the optimum activity calculation. Phys Med. 2010; 26(2): 71-9[DOI][PubMed]
  • 19. Gittoes NJ, Franklyn JA. Hyperthyroidism. Current treatment guidelines. Drugs. 1998; 55(4): 543-53[PubMed]
  • 20. Baker SG, Kramer BS. A perfect correlate does not a surrogate make. BMC Med Res Methodol. 2003; 3: 16[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiaion Alert via Google Reader

Cited By:

International Journal of Endocrinology and Metabolism accepts terms & conditions of:

International Committee of Medical Journal Editors (ICMJE) Citedby Linking DOI enabled Crossref iThenticate COPE Cross Check