International Journal of Endocrinology and Metabolism

Published by: Kowsar

Serum Phospholipase A2-IIA, hs-CRP, and Lipids in Women With Subclinical Hypothyroidism

Mohammad Hossein Shojaei Nik 1 , Masoud Darabi 2 , Amir Ziaee 3 and Fatemeh Hajmanoochehri 3 , *
Authors Information
1 Department of Biochemistry and Clinical Laboratories, International Branch (Aras), Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Liver and Gastrointestinal Disease Research Center, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, IR Iran
3 Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, IR Iran
Article information
  • International Journal of Endocrinology and Metabolism: June 01, 2014, 12 (3); e16967
  • Published Online: June 10, 2014
  • Article Type: Research Article
  • Received: January 28, 2014
  • Revised: May 9, 2014
  • Accepted: May 10, 2014
  • DOI: 10.5812/ijem.16967

To Cite: Shojaei Nik M H, Darabi M, Ziaee A, Hajmanoochehri F. Serum Phospholipase A2-IIA, hs-CRP, and Lipids in Women With Subclinical Hypothyroidism, Int J Endocrinol Metab. 2014 ;12(3):e16967. doi: 10.5812/ijem.16967.

Abstract
Copyright © 2014, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Hueston WJ, Pearson WS. Subclinical hypothyroidism and the risk of hypercholesterolemia. Ann Fam Med. 2004; 2(4): 351-5[PubMed]
  • 2. Razvi S, Weaver JU, Vanderpump MP, Pearce SH. The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort. J Clin Endocrinol Metab. 2010; 95(4): 1734-40[DOI][PubMed]
  • 3. Somwaru LL, Rariy CM, Arnold AM, Cappola AR. The natural history of subclinical hypothyroidism in the elderly: the cardiovascular health study. J Clin Endocrinol Metab. 2012; 97(6): 1962-9[DOI][PubMed]
  • 4. Imaizumi M, Akahoshi M, Ichimaru S, Nakashima E, Hida A, Soda M, et al. Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism. J Clin Endocrinol Metab. 2004; 89(7): 3365-70[DOI][PubMed]
  • 5. Pucci E, Chiovato L, Pinchera A. Thyroid and lipid metabolism. INT J OBESITY . 2000; 24-12[DOI]
  • 6. Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile. Open Cardiovasc Med J. 2011; 5: 76-84[DOI][PubMed]
  • 7. Bell RJ, Rivera-Woll L, Davison SL, Topliss DJ, Donath S, Davis SR. Well-being, health-related quality of life and cardiovascular disease risk profile in women with subclinical thyroid disease - a community-based study. Clin Endocrinol (Oxf). 2007; 66(4): 548-56[DOI][PubMed]
  • 8. Shahebrahimi K, Sharifi A, Almasi A, Taliei R, Izadi B, Karimi M. Comparison of concentrations of lipoprotein (a) and serum lipids profile in patients with subclinical hypothyroidism and euthyroidism. AMUJ. 2013; 16(73): 37-44
  • 9. Kalantari S, Heidarzadeh A. Thyroxin therapy improves serum lipoproteins and clinical findings in patients with subclinical hypothyroidism. IJEM. 2006; 2(4): 106-12
  • 10. Serter R, Demirbas B, Korukluoglu B, Culha C, Cakal E, Aral Y. The effect of L-thyroxine replacement therapy on lipid based cardiovascular risk in subclinical hypothyroidism. J Endocrinol Invest. 2004; 27(10): 897-903[PubMed]
  • 11. Shahbazian HB, Mohammadi S. Effect of 6 months L-thyroxin therapy on lipid profile of subclinical hypothyroidism. AJUMS. 2009; 8(3): 281-7
  • 12. Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J. Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clin Endocrinol (Oxf). 2004; 61(2): 232-8[DOI][PubMed]
  • 13. Duntas LH. Thyroid disease and lipids. Thyroid. 2002; 12(4): 287-93[DOI][PubMed]
  • 14. MansourianAzad R, Ghaemi E, Ahmadi AR. Serum lipid level alternation in subclinical hypothyroid patients in Gorgan (south east of Caspian sea. SJR. 2008; 4(3): 4-5
  • 15. Tuzcu A, Bahceci M, Gokalp D, Tuzun Y, Gunes K. Subclinical hypothyroidism may be associated with elevated high-sensitive c-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocr J. 2005; 52(1): 89-94[PubMed]
  • 16. Milionis HJ, Tambaki AP, Kanioglou CN, Elisaf MS, Tselepis AD, Tsatsoulis A. Thyroid substitution therapy induces high-density lipoprotein-associated platelet-activating factor-acetylhydrolase in patients with subclinical hypothyroidism: a potential antiatherogenic effect. Thyroid. 2005; 15(5): 455-60[DOI][PubMed]
  • 17. Ansar W, Ghosh S. C-reactive protein and the biology of disease. Immunol Res. 2013; 56(1): 131-42[DOI][PubMed]
  • 18. Hueston WJ, King DE, Geesey ME. Serum biomarkers for cardiovascular inflammation in subclinical hypothyroidism. Clin Endocrinol (Oxf). 2005; 63(5): 582-7[DOI][PubMed]
  • 19. Burke JE, Dennis EA. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res. 2009; 50 Suppl-42[DOI][PubMed]
  • 20. Pruzanski W, Vadas P, Stefanski E, Urowitz MB. Phospholipase A2 activity in sera and synovial fluids in rheumatoid arthritis and osteoarthritis. Its possible role as a proinflammatory enzyme. J Rheumatol. 1985; 12(2): 211-6[PubMed]
  • 21. Oorni K, Kovanen PT. Lipoprotein modification by secretory phospholipase A(2) enzymes contributes to the initiation and progression of atherosclerosis. Curr Opin Lipidol. 2009; 20(5): 421-7[DOI][PubMed]
  • 22. Hakala JK, Oorni K, Pentikainen MO, Hurt-Camejo E, Kovanen PT. Lipolysis of LDL by human secretory phospholipase A(2) induces particle fusion and enhances the retention of LDL to human aortic proteoglycans. Arterioscler Thromb Vasc Biol. 2001; 21(6): 1053-8[PubMed]
  • 23. Kramer RM, Hession C, Johansen B, Hayes G, McGray P, Chow EP, et al. Structure and properties of a human non-pancreatic phospholipase A2. J Biol Chem. 1989; 264(10): 5768-75[PubMed]
  • 24. Nevalainen TJ, Haapamäki MM, Grönroos JM. Roles of secretory phospholipases A2 in inflammatory diseases and trauma. BBA. 2000; 1488(1-2): 83-90[DOI]
  • 25. Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab. 2003; 88(6): 2438-44[DOI][PubMed]
  • 26. Vierhapper H, Nardi A, Grosser P, Raber W, Gessl A. Low-density lipoprotein cholesterol in subclinical hypothyroidism. Thyroid. 2000; 10(11): 981-4[PubMed]
  • 27. Canturk Z, Cetinarslan B, Tarkun I, Canturk NZ, Ozden M. Lipid profile and lipoprotein (a) as a risk factor for cardiovascular disease in women with subclinical hypothyroidism. Endocr Res. 2003; 29(3): 307-16[PubMed]
  • 28. Jung CH, Sung KC, Shin HS, Rhee EJ, Lee WY, Kim BS, et al. Thyroid dysfunction and their relation to cardiovascular risk factors such as lipid profile, hsCRP, and waist hip ratio in Korea. Korean J Intern Med. 2003; 18(3): 146-53[PubMed]
  • 29. Christ-Crain M, Meier C, Guglielmetti M, Huber PR, Riesen W, Staub J, et al. Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial. Atherosclerosis. 2003; 166(2): 379-86[DOI]
  • 30. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med. 2000; 132(4): 270-8[PubMed]
  • 31. Rodondi N, Aujesky D, Vittinghoff E, Cornuz J, Bauer DC. Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis. Am J Med. 2006; 119(7): 541-51[DOI][PubMed]
  • 32. Erem C. Blood coagulation, fibrinolytic activity and lipid profile in subclinical thyroid disease: subclinical hyperthyroidism increases plasma factor X activity. Clin Endocrinol (Oxf). 2006; 64(3): 323-9[DOI][PubMed]
  • 33. Schlienger JL, Vinzio S, Grunenberger F, Luca F, Goichot B. [Is subclinical hypothyroidism a cardiovascular risk factor?]. Rev Med Interne. 2006; 27(12): 927-31[DOI][PubMed]
  • 34. Boekholdt SM, Keller TT, Wareham NJ, Luben R, Bingham SA, Day NE, et al. Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol. 2005; 25(4): 839-46[DOI][PubMed]
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