International Journal of Endocrinology and Metabolism

Published by: Kowsar

Detection of Thyroid Autoimmunity Markers in Euthyroid Women With Polycystic Ovary Syndrome: A Case-Control Study From Syria

Raghad Al-Saab 1 , * and Shaden Haddad 1
Authors Information
1 Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria
Article information
  • International Journal of Endocrinology and Metabolism: July 01, 2014, 12 (3); e17954
  • Published Online: July 1, 2014
  • Article Type: Research Article
  • Received: February 24, 2014
  • Revised: April 24, 2014
  • Accepted: May 4, 2014
  • DOI: 10.5812/ijem.17954

To Cite: Al-Saab R, Haddad S. Detection of Thyroid Autoimmunity Markers in Euthyroid Women With Polycystic Ovary Syndrome: A Case-Control Study From Syria, Int J Endocrinol Metab. 2014 ; 12(3):e17954. doi: 10.5812/ijem.17954.

Copyright © 2014, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Macklon NS. Polycystic ovary syndrome. BMJ. 2011; [DOI]
  • 2. Artini PG, Uccelli A, Papini F, Simi G, Di Berardino OM, Ruggiero M, et al. Infertility and pregnancy loss in euthyroid women with thyroid autoimmunity. Gynecol Endocrinol. 2013; 29(1): 36-41[DOI][PubMed]
  • 3. Poppe K, Velkeniers B, Glinoer D. The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab. 2008; 4(7): 394-405[DOI][PubMed]
  • 4. Thangaratinam S, Tan A, Knox E, Kilby MD, Franklyn J, Coomarasamy A. Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence. BMJ. 2011; 342[DOI][PubMed]
  • 5. Janssen OE, Mehlmauer N, Hahn S, Offner AH, Gartner R. High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. Eur J Endocrinol. 2004; 150(3): 363-9[PubMed]
  • 6. Kachuei M, Jafari F, Kachuei A, Keshteli AH. Prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. Arch Gynecol Obstet. 2012; 285(3): 853-6[DOI][PubMed]
  • 7. McLachlan SM, Rapoport B. The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease. Endocr Rev. 1992; 13(2): 192-206[DOI][PubMed]
  • 8. Rotterdam EAPCWG. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004; 19(1): 41-7[PubMed]
  • 9. Balen AH, Laven JS, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update. 2003; 9(6): 505-14[PubMed]
  • 10. Petrikova J, Lazurova I, Yehuda S. Polycystic ovary syndrome and autoimmunity. Eur J Intern Med. 2010; 21(5): 369-71[DOI][PubMed]
  • 11. Escobar-Morreale HF, Luque-Ramirez M, Gonzalez F. Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertil Steril. 2011; 95(3): 1048-58 e1-2[DOI][PubMed]
  • 12. Hefler-Frischmuth K, Walch K, Huebl W, Baumuehlner K, Tempfer C, Hefler L. Serologic markers of autoimmunity in women with polycystic ovary syndrome. Fertil Steril. 2010; 93(7): 2291-4[DOI][PubMed]
  • 13. Ozdemir D, Cuhaci N, Balkan F, Usluogullari A, Ersoy R, Cakir B. Prevalence of thyroid pathologies in patients with polycystic ovary syndrome. Endocr Abstr. 2011; 26: 92
  • 14. Sinha U, Sinharay K, Saha S, Longkumer TA, Baul SN, Pal SK. Thyroid disorders in polycystic ovarian syndrome subjects: A tertiary hospital based cross-sectional study from Eastern India. Indian J Endocrinol Metab. 2013; 17(2): 304-9[DOI][PubMed]
  • 15. Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, et al. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 2003; 13(1): 3-126[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments