International Journal of Endocrinology and Metabolism

Published by: Kowsar

Anti-Hyperglycemic and Insulin Sensitizer Effects of Turmeric and Its Principle Constituent Curcumin

Zeinab Ghorbani 1 , Azita Hekmatdoost 2 and Parvin Mirmiran 2 , 3 , *
Authors Information
1 Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Science, Tehran, IR Iran
2 Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Nutrition and Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • International Journal of Endocrinology and Metabolism: October 01, 2014, 12 (4); e18081
  • Published Online: October 1, 2014
  • Article Type: Review Article
  • Received: February 21, 2014
  • Revised: June 15, 2014
  • Accepted: July 28, 2014
  • DOI: 10.5812/ijem.18081

To Cite: Ghorbani Z, Hekmatdoost A, Mirmiran P. Anti-Hyperglycemic and Insulin Sensitizer Effects of Turmeric and Its Principle Constituent Curcumin, Int J Endocrinol Metab. 2014 ;12(4):e18081. doi: 10.5812/ijem.18081.

Abstract
Copyright: Copyright © 2014, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
Footnote
References
  • 1. Agrawal S, Chakrabarti A. Pathak Y,. 2010; : 30-1
  • 2. Kotwal GJ. Kotwal GJ. Curcumin. 2010; : 217-20
  • 3. Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB. Multitargeting by turmeric, the golden spice: From kitchen to clinic. Mol Nutr Food Res. 2013; 57(9): 1510-28[DOI][PubMed]
  • 4. Tilak JC, Banerjee M, Mohan H, Devasagayam TP. Antioxidant availability of turmeric in relation to its medicinal and culinary uses. Phytother Res. 2004; 18(10): 798-804[DOI][PubMed]
  • 5. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009; 14(2): 141-53[PubMed]
  • 6. Gupta SC, Kismali G, Aggarwal BB. Curcumin, a component of turmeric: from farm to pharmacy. Biofactors. 2013; 39(1): 2-13[DOI][PubMed]
  • 7. Sohrab G, Hosseinpour-Niazi S, Hejazi J, Yuzbashian E, Mirmiran P, Azizi F. Dietary polyphenols and metabolic syndrome among Iranian adults. Int J Food Sci Nutr. 2013; 64(6): 661-7[DOI][PubMed]
  • 8. Maradana MR, Thomas R, O'Sullivan BJ. Targeted delivery of curcumin for treating type 2 diabetes. Mol Nutr Food Res. 2013; 57(9): 1550-6[DOI][PubMed]
  • 9. Rahman I, Biswas SK. 2009;
  • 10. Grynkiewicz G, Slifirski P. Curcumin and curcuminoids in quest for medicinal status. Acta Biochim Pol. 2012; 59(2): 201-12[PubMed]
  • 11. Shishodia S, Sethi G, Aggarwal BB. Curcumin: getting back to the roots. Ann N Y Acad Sci. 2005; 1056: 206-17[DOI][PubMed]
  • 12. Sahebkar A. Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome? BioFactors. 2013; 39(2): 197-208[DOI]
  • 13. Soetikno V, Suzuki K, Veeraveedu PT, Arumugam S, Lakshmanan AP, Sone H, et al. Molecular understanding of curcumin in diabetic nephropathy. Drug Discov Today. 2013; 18(15-16): 756-63[DOI][PubMed]
  • 14. Asghari G, Sheikholeslami S, Mirmiran P, Chary A, Hedayati M, Shafiee A, et al. Effect of pomegranate seed oil on serum TNF-alpha level in dyslipidemic patients. Int J Food Sci Nutr. 2012; 63(3): 368-71[DOI][PubMed]
  • 15. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR Res. 2007; 2007: 89369[DOI][PubMed]
  • 16. Panzhinskiy E, Hua Y, Lapchak PA, Topchiy E, Lehmann TE, Ren J, et al. Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. J Pharmacol Exp Ther. 2014; 349(2): 248-57[DOI][PubMed]
  • 17. Martyn JA, Kaneki M, Yasuhara S. Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology. 2008; 109(1): 137-48[DOI][PubMed]
  • 18. Paul S. Metabolic consequences of hyperglycemia and insulin resistance. Clinical Cornerstone. 2007; 8-42[DOI]
  • 19. Bahadoran Z, Mirmiran P, Azizi F. Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications. J Med Food. 2013; 16(5): 375-82[DOI][PubMed]
  • 20. Hekmatdoost A, Mirmiran P, Hosseini-Esfahani F, Azizi F. Dietary fatty acid composition and metabolic syndrome in Tehranian adults. Nutrition. 2011; 27(10): 1002-7[DOI][PubMed]
  • 21. Shao W, Yu Z, Chiang Y, Yang Y, Chai T, Foltz W, et al. Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS One. 2012; 7(1)[DOI][PubMed]
  • 22. Bahadoran Z, Mirmiran P, Azizi F. Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord. 2013; 12(1): 43[DOI][PubMed]
  • 23. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005; 54(6): 1615-25[PubMed]
  • 24. Campos C. Chronic hyperglycemia and glucose toxicity: pathology and clinical sequelae. Postgrad Med. 2012; 124(6): 90-7[DOI][PubMed]
  • 25. Peeyush KT , Gireesh G, Jobin M, Paulose CS. Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats Life sciences. 2009; 85(19-20)
  • 26. Na LX, Zhang YL, Li Y, Liu LY, Li R, Kong T, et al. Curcumin improves insulin resistance in skeletal muscle of rats Nutr Metab Cardiovasc Dis. [Research Support, Non-U.S. Gov’t]. 2011; (7)
  • 27. El-Moselhy MA, Taye A, Sharkawi SS, El-Sisi SF, Ahmed AF. The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-alpha and free fatty acids. Food Chem Toxicol. 2011; 49(5): 1129-40[DOI][PubMed]
  • 28. Arun N, Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr. 2002; 57(1): 41-52[PubMed]
  • 29. Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology. 2008; 149(7): 3549-58[DOI][PubMed]
  • 30. Seo KI, Choi MS, Jung UJ, Kim HJ, Yeo J, Jeon SM, et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res. 2008; 52(9): 995-1004[DOI][PubMed]
  • 31. Kuroda M, Mimaki Y, Nishiyama T, Mae T, Kishida H, Tsukagawa M, et al. Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biol Pharm Bull. 2005; 28(5): 937-9[PubMed]
  • 32. Li Y, Zhang Y, Liu DB, Liu HY, Hou WG, Dong YS. Curcumin attenuates diabetic neuropathic pain by downregulating TNF-alpha in a rat model. Int J Med Sci. 2013; 10(4): 377-81[DOI][PubMed]
  • 33. Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, et al. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005; 53(4): 959-63[DOI][PubMed]
  • 34. Mohankumar S, McFarlane JR. An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. Phytother Res. 2011; 25(3): 396-401[DOI][PubMed]
  • 35. Cheng TC, Lin CS, Hsu CC, Chen LJ, Cheng KC, Cheng JT. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats. Neurosci Lett. 2009; 465(3): 238-41[DOI][PubMed]
  • 36. Pan Y, Wang Y, Cai L, Cai Y, Hu J, Yu C, et al. Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats. Br J Pharmacol. 2012; 166(3): 1169-82[DOI][PubMed]
  • 37. Jang EM, Choi MS, Jung UJ, Kim MJ, Kim HJ, Jeon SM, et al. Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters. Metabolism. 2008; 57(11): 1576-83[DOI][PubMed]
  • 38. Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, et al. Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One. 2012; 7(12)[DOI][PubMed]
  • 39. Sharma S, Kulkarni SK, Chopra K. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2006; 33(10): 940-5[DOI][PubMed]
  • 40. Soetikno V, Sari FR, Veeraveedu PT, Thandavarayan RA, Harima M, Sukumaran V, et al. Curcumin ameliorates macrophage infiltration by inhibiting NF-kappaB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy. Nutr Metab (Lond). 2011; 8(1): 35[DOI][PubMed]
  • 41. Fujiwara H, Hosokawa M, Zhou X, Fujimoto S, Fukuda K, Toyoda K, et al. Curcumin inhibits glucose production in isolated mice hepatocytes. Diabetes Res Clin Pract. 2008; 80(2): 185-91[DOI][PubMed]
  • 42. Kanitkar M, Gokhale K, Galande S, Bhonde RR. Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. Br J Pharmacol. 2008; 155(5): 702-13[DOI][PubMed]
  • 43. Best L, Elliott AC, Brown PD. Curcumin induces electrical activity in rat pancreatic beta-cells by activating the volume-regulated anion channel. Biochem Pharmacol. 2007; 73(11): 1768-75[DOI][PubMed]
  • 44. Ceriello A, Falleti E, Motz E, Taboga C, Tonutti L, Ezsol Z, et al. Hyperglycemia-induced circulating ICAM-1 increase in diabetes mellitus: the possible role of oxidative stress. Horm Metab Res. 1998; 30(3): 146-9[DOI][PubMed]
  • 45. Gustavsson C, Agardh CD, Zetterqvist AV, Nilsson J, Agardh E, Gomez MF. Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia. PLoS One. 2010; 5(9)[DOI][PubMed]
  • 46. Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M, et al. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial Mol Nutr Food Res. [Research Support, Non-U.S. Gov’t]. 2013; (9)
  • 47. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012; 35(11): 2121-7
  • 48. Tang M, Larson-Meyer DE, Liebman M. Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects. Am J Clin Nutr. 2008; 87(5): 1262-7[PubMed]
  • 49. Kim SW, Ha KC, Choi EK, Jung SY, Kim MG, Kwon DY, et al. The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study. BMC Complement Altern Med. 2013; 13: 58[DOI][PubMed]
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