International Journal of Endocrinology and Metabolism

Published by: Kowsar

The Effects of Vitamin D on Insulin Release From Isolated Islets of Rats

Authors Information
1 Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article Notes and Dates
International Journal of Endocrinology and Metabolism: January 2015, 13 (1); e20620.Published Online: January 1, 2015
Article Type: Research Article; Received : May 24, 2014; Revised : August 11, 2014; Accepted : October 19, 2014

To Cite : Jeddi S, Syedmoradi L, Bagheripour F, Ghasemi A. The Effects of Vitamin D on Insulin Release From Isolated Islets of Rats, Int J Endocrinol Metab. 2015 ;13(1):e20620. doi: 10.5812/ijem.20620.

Copyright: Copyright © 2015, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Maria Rotella C, Pala L, Mannucci E. Role of insulin in the type 2 diabetes therapy: past, present and future. Int J Endocrinol Metab. 2013; 11(3): 137-44[DOI][PubMed]
  • 2. Ghasemi A, Zahediasl S. Potential therapeutic effects of nitrate/nitrite and type 2 diabetes mellitus. Int J Endocrinol Metab. 2013; 11(2): 63-4[DOI][PubMed]
  • 3. Alvarez JA, Ashraf A. Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol. 2010; 2010: 351385[DOI][PubMed]
  • 4. Bourlon PM, Faure-Dussert A, Billaudel B. Modulatory role of 1,25 dihydroxyvitamin D3 on pancreatic islet insulin release via the cyclic AMP pathway in the rat. Br J Pharmacol. 1997; 121(4): 751-8[DOI][PubMed]
  • 5. Riachy R, Vandewalle B, Kerr Conte J, Moerman E, Sacchetti P, Lukowiak B, et al. 1,25-dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine-induced apoptosis: implication of the antiapoptotic protein A20. Endocrinology. 2002; 143(12): 4809-19[DOI][PubMed]
  • 6. Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia. 2005; 48(7): 1247-57[DOI][PubMed]
  • 7. Palomer X, Gonzalez-Clemente JM, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab. 2008; 10(3): 185-97[DOI][PubMed]
  • 8. Billaudel BJ, Faure AG, Sutter BC. Effect of 1,25 dihydroxyvitamin D3 on isolated islets from vitamin D3-deprived rats. Am J Physiol. 1990; 258(4 Pt 1)-8[PubMed]
  • 9. Bourlon PM, Billaudel B, Faure-Dussert A. Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol. 1999; 160(1): 87-95[PubMed]
  • 10. Cade C, Norman AW. Rapid normalization/stimulation by 1,25-dihydroxyvitamin D3 of insulin secretion and glucose tolerance in the vitamin D-deficient rat. Endocrinology. 1987; 120(4): 1490-7[DOI][PubMed]
  • 11. Dalgard C, Petersen MS, Weihe P, Grandjean P. Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians. Diabetes Care. 2011; 34(6): 1284-8[DOI][PubMed]
  • 12. Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol. 2006; 92(1): 39-48[DOI][PubMed]
  • 13. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357(3): 266-81[DOI][PubMed]
  • 14. Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG. Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J. 2003; 17(3): 509-11[DOI][PubMed]
  • 15. Nikooyeh B, Neyestani TR, Farvid M, Alavi-Majd H, Houshiarrad A, Kalayi A, et al. Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr. 2011; 93(4): 764-71[DOI][PubMed]
  • 16. Krus U, Kotova O, Spegel P, Hallgard E, Sharoyko VV, Vedin A, et al. Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells. Biochem J. 2010; 429(1): 205-13[DOI][PubMed]
  • 17. Farahani H, Ghasemi A, Roghani M, Zahediasl S. The effect of maternal hypothyroidism on the carbohydrate metabolism and insulin secretion of isolated islets in adult male offspring of rats. Horm Metab Res. 2010; 42(11): 792-7[DOI][PubMed]
  • 18. Mahmoodzadeh Sagheb M, Azarpira N, Yaghobi R. The Effect of Leptin and Adiponectin on KiSS-1 and KissR mRNA Expression in Rat Islets of Langerhans and CRI-D2 Cell Line. Int J Endocrinol Metab. 2014; 12(2)[DOI][PubMed]
  • 19. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr. 2010; 103(4): 549-55[DOI][PubMed]
  • 20. Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabet Med. 2009; 26(1): 19-27[DOI][PubMed]
  • 21. Kayaniyil S, Vieth R, Retnakaran R, Knight JA, Qi Y, Gerstein HC, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care. 2010; 33(6): 1379-81[DOI][PubMed]
  • 22. Faure A, Sutter BC, Billaudel B. Is 1,25-dihydroxyvitamin D3 the specific vitamin D3 metabolite active on insulin release and calcium handling by islets from vitamin D3-deprived rats? Diabete Metab. 1991; 17(2): 271-8[PubMed]
  • 23. Tanaka Y, Seino Y, Ishida M, Yamaoka K, Yabuuchi H, Ishida H, et al. Effect of vitamin D3 on the pancreatic secretion of insulin and somatostatin. Acta Endocrinol (Copenh). 1984; 105(4): 528-33[PubMed]
  • 24. Bourlon PM, Faure-Dussert A, Billaudel B, Sutter BC, Tramu G, Thomasset M. Relationship between calbindin-D28K levels in the A and B cells of the rat endocrine pancreas and the secretion of insulin and glucagon: influence of vitamin D3 deficiency and 1,25-dihydroxyvitamin D3. J Endocrinol. 1996; 148(2): 223-32[PubMed]
  • 25. d'Emden MC, Dunlop M, Larkins RG, Wark JD. The in vitro effect of 1 alpha,25-dihydroxyvitamin D3 on insulin production by neonatal rat islets. Biochem Biophys Res Commun. 1989; 164(1): 413-8[PubMed]
  • 26. chan JC, Rogers KS. Lack of influence of vitamin D deficiency on insulin release from the isolated pancreatic islets of rats. Experientia. 1986; 42(11-12): 1253-4[PubMed]
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