International Journal of Endocrinology and Metabolism

Published by: Kowsar

Effect of Vitamin D Supplementation on Glucose Control and Inflammatory Response in Type II Diabetes: A Double Blind, Randomized Clinical Trial

Mohammed E. Al-Sofiani 1 , 2 , * , Anwar Jammah 2 , Michael Racz 1 , Rajab A. Khawaja 2 , Rana Hasanato 2 , Hassan A. N. El-Fawal 1 , Shaker A. Mousa 1 , 3 and Darius L. Mason 1
Authors Information
1 Internal Medicine, Catholic Health System, University at Buffalo, Buffalo, New York, USA
2 College of Medicine, King Saud University, Riyadh, Saudi Arabia
3 Pharmaceutical Research Institute, Rensselaer, New York, USA
Article information
  • International Journal of Endocrinology and Metabolism: January 01, 2015, 13 (1); e22604
  • Published Online: January 10, 2015
  • Article Type: Research Article
  • Received: August 8, 2014
  • Revised: November 16, 2014
  • Accepted: November 24, 2014
  • DOI: 10.5812/ijem.22604

To Cite: Al-Sofiani M E, Jammah A, Racz M, Khawaja R A, Hasanato R, et al. Effect of Vitamin D Supplementation on Glucose Control and Inflammatory Response in Type II Diabetes: A Double Blind, Randomized Clinical Trial, Int J Endocrinol Metab. 2015 ;13(1):e22604. doi: 10.5812/ijem.22604.

Abstract
Copyright © 2015, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. 2013;
  • 2. Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357(3): 266-81[DOI][PubMed]
  • 3. Maestro B, Davila N, Carranza MC, Calle C. Identification of a Vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol. 2003; 84(2-3): 223-30[PubMed]
  • 4. Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG. Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J. 2003; 17(3): 509-11[DOI][PubMed]
  • 5. Garcia C, Feve B, Ferre P, Halimi S, Baizri H, Bordier L, et al. Diabetes and inflammation: fundamental aspects and clinical implications. Diabetes Metab. 2010; 36(5): 327-38[DOI][PubMed]
  • 6. Goldberg RB. Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab. 2009; 94(9): 3171-82[DOI][PubMed]
  • 7. Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Zuodar G, et al. Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis. 2005; 183(2): 259-67[DOI][PubMed]
  • 8. Kositsawat J, Freeman VL, Gerber BS, Geraci S. Association of A1C levels with vitamin D status in U.S. adults: data from the National Health and Nutrition Examination Survey. Diabetes Care. 2010; 33(6): 1236-8[DOI][PubMed]
  • 9. Hypponen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care. 2006; 29(10): 2244-6[DOI][PubMed]
  • 10. Nikooyeh B, Neyestani TR, Farvid M, Alavi-Majd H, Houshiarrad A, Kalayi A, et al. Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr. 2011; 93(4): 764-71[DOI][PubMed]
  • 11. Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract. 2003; 57(4): 258-61[PubMed]
  • 12. Witham MD, Dove FJ, Dryburgh M, Sugden JA, Morris AD, Struthers AD. The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial. Diabetologia. 2010; 53(10): 2112-9[DOI][PubMed]
  • 13. Al-Shoumer KA, Al-Asousi AA, Doi SA, Vasanthy BA. Serum leptin and its relationship with metabolic variables in Arabs with type 2 diabetes mellitus. Ann Saudi Med. 2008; 28(5): 367-70[PubMed]
  • 14. Dietary Reference Intakes for Calcium and Vitamin D. 2011;
  • 15. Kajikawa M, Ishida H, Fujimoto S, Mukai E, Nishimura M, Fujita J, et al. An insulinotropic effect of vitamin D analog with increasing intracellular Ca2+ concentration in pancreatic beta-cells through nongenomic signal transduction. Endocrinology. 1999; 140(10): 4706-12[DOI][PubMed]
  • 16. Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol. 2004; 89-90(1-5): 121-5[DOI][PubMed]
  • 17. Al-Daghri NM, Alkharfy KM, Al-Othman A, El-Kholie E, Moharram O, Alokail MS, et al. Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month prospective interventional study. Cardiovasc Diabetol. 2012; 11: 85[DOI][PubMed]
  • 18. Vaidya A, Williams JS. The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes. Metabolism. 2012; 61(4): 450-8[DOI][PubMed]
  • 19. Moebus S, Gores L, Losch C, Jockel KH. Impact of time since last caloric intake on blood glucose levels. Eur J Epidemiol. 2011; 26(9): 719-28[DOI][PubMed]
  • 20. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr. 2010; 103(4): 549-55[DOI][PubMed]
  • 21. Inomata S, Kadowaki S, Yamatani T, Fukase M, Fujita T. Effect of 1 alpha (OH)-vitamin D3 on insulin secretion in diabetes mellitus. Bone Miner. 1986; 1(3): 187-92[PubMed]
  • 22. Al-Daghri NM, Al-Attas OS, Al-Okail MS, Alkharfy KM, Al-Yousef MA, Nadhrah HM, et al. Severe hypovitaminosis D is widespread and more common in non-diabetics than diabetics in Saudi adults. Saudi Med J. 2010; 31(7): 775-80[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments