International Journal of Endocrinology and Metabolism

Published by: Kowsar

Beneficial Effect of Troxerutin on Diabetes-Induced Vascular Damages in Rat Aorta: Histopathological Alterations and Antioxidation Mechanism

Reza Badalzadeh 1 , Nayeleh Layeghzadeh 2 , 3 , Alireza Alihemmati 4 , * and Mustafa Mohammadi 3
Authors Information
1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
3 Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran
4 Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • International Journal of Endocrinology and Metabolism: April 01, 2015, 13 (2); e25969
  • Published Online: April 30, 2015
  • Article Type: Research Article
  • Received: December 9, 2014
  • Revised: January 24, 2015
  • Accepted: March 3, 2015
  • DOI: 10.5812/ijem.25969

To Cite: Badalzadeh R, Layeghzadeh N, Alihemmati A, Mohammadi M. Beneficial Effect of Troxerutin on Diabetes-Induced Vascular Damages in Rat Aorta: Histopathological Alterations and Antioxidation Mechanism, Int J Endocrinol Metab. 2015 ;13(2):e25969. doi: 10.5812/ijem.25969.

Abstract
Copyright © 2015, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5): 1047-53[PubMed]
  • 2. Avogaro A, Albiero M, Menegazzo L, de Kreutzenberg S, Fadini GP. Endothelial dysfunction in diabetes: the role of reparatory mechanisms. Diabetes Care. 2011; 34 Suppl 2-90[DOI][PubMed]
  • 3. Paneni F, Beckman JA, Creager MA, Cosentino F. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Eur Heart J. 2013; 34(31): 2436-43[DOI][PubMed]
  • 4. Sena CM, Pereira AM, Seica R. Endothelial dysfunction - a major mediator of diabetic vascular disease. Biochim Biophys Acta. 2013; 1832(12): 2216-31[DOI][PubMed]
  • 5. Fowler MJ. Microvascular and Macrovascular Complications of Diabetes. Clin Diabetes. 2008; 26(2): 77-82
  • 6. Tiwari BK, Pandey KB, Abidi AB, Rizvi SI. Markers of Oxidative Stress during Diabetes Mellitus. J Biom. 2013; 2013: 8
  • 7. Fiorentino TV, Prioletta A, Zuo P, Folli F. Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr Pharm Des. 2013; 19(32): 5695-703[PubMed]
  • 8. Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010; 107(9): 1058-70[PubMed]
  • 9. Alper G, Olukman M, Irer S, Caglayan O, Duman E, Yilmaz C, et al. Effect of vitamin E and C supplementation combined with oral antidiabetic therapy on the endothelial dysfunction in the neonatally streptozotocin injected diabetic rat. Diabetes Metab Res Rev. 2006; 22(3): 190-7[DOI][PubMed]
  • 10. Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother. 2005; 59(7): 365-73[DOI][PubMed]
  • 11. Yang X, Wang F, Hu S. The electrochemical oxidation of troxerutin and its sensitive determination in pharmaceutical dosage forms at PVP modified carbon paste electrode. Colloids Surf B Biointerfaces. 2006; 52(1): 8-13[DOI][PubMed]
  • 12. Heidarzadeh F, Badalzadeh R, Hatami H. The effect of troxerutin on lipid peroxidation and tissue injury induced by myocardial ischemia reperfusion injury in diabetic rat. Razi J Med Sci. 2014; 21(125): 37-45
  • 13. Maurya DK, Balakrishnan S, Salvi VP, Nair CK. Protection of cellular DNA from gamma-radiation-induced damages and enhancement in DNA repair by troxerutin. Mol Cell Biochem. 2005; 280(1-2): 57-68[DOI][PubMed]
  • 14. Lu J, Wu DM, Zheng YL, Hu B, Cheng W, Zhang ZF, et al. Troxerutin counteracts domoic acid-induced memory deficits in mice by inhibiting CCAAT/enhancer binding protein beta-mediated inflammatory response and oxidative stress. J Immunol. 2013; 190(7): 3466-79[DOI][PubMed]
  • 15. Fan SH, Zhang ZF, Zheng YL, Lu J, Wu DM, Shan Q, et al. Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation. Int Immunopharmacol. 2009; 9(1): 91-6[DOI][PubMed]
  • 16. Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q, et al. Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose. J Agric Food Chem. 2009; 57(17): 7731-6[DOI][PubMed]
  • 17. Lu J, Wu DM, Hu B, Cheng W, Zheng YL, Zhang ZF, et al. Chronic administration of troxerutin protects mouse brain against D-galactose-induced impairment of cholinergic system. Neurobiol Learn Mem. 2010; 93(2): 157-64[DOI][PubMed]
  • 18. Lu J, Wu DM, Zheng ZH, Zheng YL, Hu B, Zhang ZF. Troxerutin protects against high cholesterol-induced cognitive deficits in mice. Brain. 2011; 134: 783-97[DOI][PubMed]
  • 19. Gohel MS, Davies AH. Pharmacological agents in the treatment of venous disease: an update of the available evidence. Curr Vasc Pharmacol. 2009; 7(3): 303-8[PubMed]
  • 20. Pari L, Monisha P, Mohamed Jalaludeen A. Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats. Eur J Pharmacol. 2012; 691(1-3): 143-50[DOI][PubMed]
  • 21. Badalzadeh R, Mohammadi M, Najafi M, Ahmadiasl N, Farajnia S, Ebrahimi H. The additive effects of ischemic postconditioning and cyclosporine-A on nitric oxide activity and functions of diabetic myocardium injured by ischemia/reperfusion. J Cardiovasc Pharmacol Ther. 2012; 17(2): 181-9[DOI][PubMed]
  • 22. Geetha R, Yogalakshmi B, Sreeja S, Bhavani K, Anuradha CV. Troxerutin suppresses lipid abnormalities in the heart of high-fat-high-fructose diet-fed mice. Mol Cell Biochem. 2014; 387(1-2): 123-34[DOI][PubMed]
  • 23. Sampath S, Karundevi B. Effect of troxerutin on insulin signaling molecules in the gastrocnemius muscle of high fat and sucrose-induced type-2 diabetic adult male rat. Mol Cell Biochem. 2014; 395(1-2): 11-27[DOI][PubMed]
  • 24. Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q, et al. Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. Biochem Pharmacol. 2014; 91(1): 74-86[DOI][PubMed]
  • 25. Fraga CG, Leibovitz BE, Tappel AL. Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes. Free Radic Biol Med. 1988; 4(3): 155-61[PubMed]
  • 26. Badalzadeh R, Mohammadi M, Yousefi B, Faranjia S, Najafi M, Mohammadi S. Involvement of Glycogen Synthase Kinase-3β and Oxidation Status in the Loss of Cardioprotection by Postconditioning in Chronic Diabetic Male Rats. Adv Pharm Bull. 2015; 5(1)
  • 27. Ghyasi R, Sepehri G, Mohammadi M, Badalzadeh R, Ghyasi A. Effect of mebudipine on oxidative stress and lipid peroxidation in myocardial ischemic-reperfusion injury in male rat. J Res Med Sci. 2012; 17(12): 1150-5[PubMed]
  • 28. Chung HK, Choi SM, Ahn BO, Kwak HH, Kim JH, Kim WB. Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy. Arzneimittelforschung. 2005; 55(10): 573-80[DOI][PubMed]
  • 29. Elangovan P, Pari L. Ameliorating effects of troxerutin on nickel-induced oxidative stress in rats. Redox Rep. 2013; 18(6): 224-32[PubMed]
  • 30. Roghani Dehkordi F, Roghani M. Mechanisms Underlying Sesamolin-Induced Attenuation of Vascular Dysfunction in Rats With Streptozotocin-Induced Diabetes. Int J Endocrinol Metab. 2011; 9(2): 311-6
  • 31. Yan LJ. Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress. J Diabetes Res. 2014; 2014: 137919[PubMed]
  • 32. Nassar T, Kadery B, Lotan C, Da'as N, Kleinman Y, Haj-Yehia A. Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2002; 436(1-2): 111-8[PubMed]
  • 33. Paneni F, Mocharla P, Akhmedov A, Costantino S, Osto E, Volpe M, et al. Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes. Circ Res. 2012; 111(3): 278-89[PubMed]
  • 34. Patel H, Chen J, Das KC, Kavdia M. Hyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC. Cardiovasc Diabetol. 2013; 12: 142[DOI][PubMed]
  • 35. Ebrahimi H, Badalzadeh R, Mohammadi M, Yousefi B. Diosgenin attenuates inflammatory response induced by myocardial reperfusion injury: role of mitochondrial ATP-sensitive potassium channels. J Physiol Biochem. 2014; 70(2): 425-32[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments