International Journal of Endocrinology and Metabolism

Published by: Kowsar

Rapid Levothyroxine Absorption Testing: A Case Series of Nonadherent Patients

Mamtha Balla 1 , Ram M. Jhingan 2 and Daniel J. Rubin 3 , *
Authors Information
1 Abington Memorial Hospital, Abington, USA
2 Einstein Medical Center Montgomery, East Norriton, USA
3 School of Medicine, Temple University, Philadelphia, USA
Article information
  • International Journal of Endocrinology and Metabolism: October 01, 2015, 13 (4); e31051
  • Published Online: October 13, 2015
  • Article Type: Brief Report
  • Received: June 26, 2015
  • Revised: July 28, 2015
  • Accepted: August 22, 2015
  • DOI: 10.5812/ijem.31051

To Cite: Balla M, Jhingan R M, Rubin D J. Rapid Levothyroxine Absorption Testing: A Case Series of Nonadherent Patients, Int J Endocrinol Metab. 2015 ;13(4):e31051. doi: 10.5812/ijem.31051.

Abstract
Copyright: Copyright © 2015, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Footnote
References
  • 1. Gaitonde DY, Rowley KD, Sweeney LB. Hypothyroidism: an update. Am Fam Physician. 2012; 86(3): 244-51[PubMed]
  • 2. Surks MI, Sievert R. Drugs and thyroid function. N Engl J Med. 1995; 333(25): 1688-94[DOI][PubMed]
  • 3. Ain KB, Refetoff S, Fein HG, Weintraub BD. Pseudomalabsorption of levothyroxine. JAMA. 1991; 266(15): 2118-20[PubMed]
  • 4. Mersebach H, Rasmussen AK, Kirkegaard L, Feldt-Rasmussen U. Intestinal adsorption of levothyroxine by antacids and laxatives: case stories and in vitro experiments. Pharmacol Toxicol. 1999; 84(3): 107-9[PubMed]
  • 5. Azizi F, Belur R, Albano J. Malabsorption of thyroid hormones after jejunoileal bypass for obesity. Ann Intern Med. 1979; 90(6): 941-2[PubMed]
  • 6. Eledrisi MS, Szymajda A, Alshanti M, Urban RJ. Noncompliance with medical treatment: pseudomalabsorption of levothyroxine. South Med J. 2001; 94(8): 833-6[PubMed]
  • 7. Lips DJ, van Reisen MT, Voigt V, Venekamp W. Diagnosis and treatment of levothyroxine pseudomalabsorption. Neth J Med. 2004; 62(4): 114-8[PubMed]
  • 8. Srinivas V, Oyibo SO. Levothyroxine pseudomalabsorption and thyroxine absorption testing with use of high-dose levothyroxine: case report and discussion. Endocr Pract. 2010; 16(6): 1012-5[DOI][PubMed]
  • 9. Sun GE, Pantalone KM, Faiman C, Gupta M, Olansky L, Hatipoglu B. The clinical utility of free thyroxine in oral levothyroxine absorption testing. Endocr Pract. 2014; 20(9): 925-9[DOI][PubMed]
  • 10. Vita R, Benvenga S. Tablet levothyroxine (L-T4) malabsorption induced by proton pump inhibitor; a problem that was solved by switching to L-T4 in soft gel capsule. Endocr Pract. 2014; 20(3)-41[DOI][PubMed]
  • 11. Livadariu E, Valdes-Socin H, Burlacu MC, Vulpoi C, Daly AF, Beckers A. Pseudomalabsorption of thyroid hormones: case report and review of the literature. Ann Endocrinol (Paris). 2007; 68(6): 460-3[DOI][PubMed]
  • 12. Ogawa D, Otsuka F, Mimura U, Ueno A, Hashimoto H, Kishida M, et al. Pseudomalabsorption of levothyroxine: a case report. Endocr J. 2000; 47(1): 45-50[PubMed]
  • 13. Walker JN, Shillo P, Ibbotson V, Vincent A, Karavitaki N, Weetman AP, et al. A thyroxine absorption test followed by weekly thyroxine administration: a method to assess non-adherence to treatment. Eur J Endocrinol. 2013; 168(6): 913-7[DOI][PubMed]
  • 14. Goichot B, Vinzio S, Luca F, Sirlin X, Sapin R, Schlienger JL. In vivo evidence for a direct ultra-fast negative feedback of thyroxine on TSH secretion in humans: a case of L-thyroxine pseudomalabsorption. Clin Endocrinol (Oxf). 2007; 67(6): 952-3[DOI][PubMed]
  • 15. Mandel SJ, Brent GA, Larsen PR. Levothyroxine therapy in patients with thyroid disease. Ann Intern Med. 1993; 119(6): 492-502[PubMed]
  • 16. Morris JC. How do you approach the problem of TSH elevation in a patient on high-dose thyroid hormone replacement? Clin Endocrinol (Oxf). 2009; 70(5): 671-3[DOI][PubMed]
  • 17. Liwanpo L, Hershman JM. Conditions and drugs interfering with thyroxine absorption. Best Pract Res Clin Endocrinol Metab. 2009; 23(6): 781-92[DOI][PubMed]
  • 18. Benvenga S, Bartolone L, Squadrito S, Lo Giudice F, Trimarchi F. Delayed intestinal absorption of levothyroxine. Thyroid. 1995; 5(4): 249-53[PubMed]
  • 19. Kubota S, Fukata S, Matsuzuka F, Kuma K, Miyauchi A. Successful management of a patient with pseudomalabsorption of levothyroxine. Int J Psychiatry Med. 2003; 33(2): 183-8[PubMed]
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