International Journal of Endocrinology and Metabolism

Published by: Kowsar

Leptin Resistance: A Possible Interface Between Obesity and Pulmonary-Related Disorders

Abdul Rehman Khan 1 , 2 , * and Fazli Rabbi Awan 1
Authors Information
1 Diabetes and Cardio-Metabolic Disorders Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan
2 Obesity and Diabetes Research Laboratory, Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan
Article information
  • International Journal of Endocrinology and Metabolism: January 01, 2016, 14 (1); e32586
  • Published Online: February 12, 2016
  • Article Type: Review Article
  • Received: August 20, 2015
  • Revised: December 1, 2015
  • Accepted: January 3, 2016
  • DOI: 10.5812/ijem.32586

To Cite: Rehman Khan A, Awan F R. Leptin Resistance: A Possible Interface Between Obesity and Pulmonary-Related Disorders, Int J Endocrinol Metab. 2016 ; 14(1):e32586. doi: 10.5812/ijem.32586.

Copyright © 2016, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Farooqi S, O'Rahilly S. Genetics of obesity in humans. Endocr Rev. 2006; 27(7): 710-8[DOI][PubMed]
  • 2. Yang W, Kelly T, He J. Genetic epidemiology of obesity. Epidemiol Rev. 2007; 29: 49-61[DOI][PubMed]
  • 3. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998; 395(6704): 763-70[DOI][PubMed]
  • 4. Martin SS, Qasim A, Reilly MP. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol. 2008; 52(15): 1201-10[DOI][PubMed]
  • 5. Myers MJ, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab. 2010; 21(11): 643-51[DOI][PubMed]
  • 6. Goodpaster BH, Krishnaswami S, Harris TB, Katsiaras A, Kritchevsky SB, Simonsick EM, et al. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med. 2005; 165(7): 777-83[DOI][PubMed]
  • 7. Boulet LP. Asthma and obesity. Clin Exp Allergy. 2013; 43(1): 8-21[DOI][PubMed]
  • 8. Arteaga-Solis E, Zee T, Emala CW, Vinson C, Wess J, Karsenty G. Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab. 2013; 17(1): 35-48[DOI][PubMed]
  • 9. Castro-Rodriguez JA. [Relationship between obesity and asthma]. Arch Bronconeumol. 2007; 43(3): 171-5[PubMed]
  • 10. Phipps PR, Starritt E, Caterson I, Grunstein RR. Association of serum leptin with hypoventilation in human obesity. Thorax. 2002; 57(1): 75-6[PubMed]
  • 11. Olson AL, Zwillich C. The obesity hypoventilation syndrome. Am J Med. 2005; 118(9): 948-56[DOI][PubMed]
  • 12. Canoz M, Erdenen F, Uzun H, Muderrisoglu C, Aydin S. The relationship of inflammatory cytokines with asthma and obesity. Clin Invest Med. 2008; 31(6)-9[PubMed]
  • 13. Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, et al. Imbalance between neutrophil elastase and its inhibitor alpha1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013; 17(4): 534-48[DOI][PubMed]
  • 14. Stockley RA. Neutrophils and protease/antiprotease imbalance. Am J Respir Crit Care Med. 1999; 160(5 Pt 2)-52[DOI][PubMed]
  • 15. Ranes J, Stoller JK. A review of alpha-1 antitrypsin deficiency. Semin Respir Crit Care Med. 2005; 26(2): 154-66[DOI][PubMed]
  • 16. Gadek JE, Pacht ER. The protease-antiprotease balance within the human lung: implications for the pathogenesis of emphysema. Lung. 1990; 168 Suppl: 552-64[PubMed]
  • 17. Huang L, Li C. Leptin: a multifunctional hormone. Cell Res. 2000; 10(2): 81-92[DOI][PubMed]
  • 18. Friedman JM. A tale of two hormones. Nat Med. 2010; 16(10): 1100-6[DOI][PubMed]
  • 19. Bates SH, Myers MJ. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab. 2003; 14(10): 447-52[PubMed]
  • 20. Harvey J, Ashford ML. Leptin in the CNS: much more than a satiety signal. Neuropharmacology. 2003; 44(7): 845-54[PubMed]
  • 21. Enriori PJ, Evans AE, Sinnayah P, Cowley MA. Leptin resistance and obesity. Obesity (Silver Spring). 2006; 14 Suppl 5: 254S-8S[DOI][PubMed]
  • 22. Patel HR, Qi Y, Hawkins EJ, Hileman SM, Elmquist JK, Imai Y, et al. Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Diabetes. 2006; 55(11): 3091-8[DOI][PubMed]
  • 23. Mark AL, Correia ML, Rahmouni K, Haynes WG. Loss of leptin actions in obesity: two concepts with cardiovascular implications. Clin Exp Hypertens. 2004; 26(7-8): 629-36[PubMed]
  • 24. Palmer G, Aurrand-Lions M, Contassot E, Talabot-Ayer D, Ducrest-Gay D, Vesin C, et al. Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J Immunol. 2006; 177(5): 2899-907[PubMed]
  • 25. Paz-Filho G, Mastronardi C, Delibasi T, Wong ML, Licinio J. Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy. Arq Bras Endocrinol Metabol. 2010; 54(8): 690-7[PubMed]
  • 26. Hu FB, Chen C, Wang B, Stampfer MJ, Xu X. Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population. Int J Obes Relat Metab Disord. 2001; 25(1): 121-5[PubMed]
  • 27. Maachi M, Pieroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, et al. Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women. Int J Obes Relat Metab Disord. 2004; 28(8): 993-7[DOI][PubMed]
  • 28. Stanley S, Wynne K, McGowan B, Bloom S. Hormonal regulation of food intake. Physiol Rev. 2005; 85(4): 1131-58[DOI][PubMed]
  • 29. Chen K, Li F, Li J, Cai H, Strom S, Bisello A, et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med. 2006; 12(4): 425-32[DOI][PubMed]
  • 30. Baumann H, Gauldie J. The acute phase response. Immunol Today. 1994; 15(2): 74-80[DOI][PubMed]
  • 31. Moshage H. Cytokines and the hepatic acute phase response. J Pathol. 1997; 181(3): 257-66[DOI][PubMed]
  • 32. Morgan K, Marsters P, Morley S, van Gent D, Hejazi A, Backx M, et al. Oncostatin M induced alpha1-antitrypsin (AAT) gene expression in Hep G2 cells is mediated by a 3' enhancer. Biochem J. 2002; 365: 555-60[DOI][PubMed]
  • 33. Morgan K, Scobie G, Marsters P, Kalsheker NA. Mutation in an alpha1-antitrypsin enhancer results in an interleukin-6 deficient acute-phase response due to loss of cooperativity between transcription factors. Biochim Biophys Acta. 1997; 1362(1): 67-76[PubMed]
  • 34. Barbey-Morel C, Pierce JA, Campbell EJ, Perlmutter DH. Lipopolysaccharide modulates the expression of alpha 1 proteinase inhibitor and other serine proteinase inhibitors in human monocytes and macrophages. J Exp Med. 1987; 166(4): 1041-54[PubMed]
  • 35. Sallenave JM, Tremblay GM, Gauldie J, Richards CD. Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha1-proteinase inhibitor in A549 human alveolar epithelial cells. J Interferon Cytokine Res. 1997; 17(6): 337-46[PubMed]
  • 36. Zhou J, Lei W, Shen L, Luo HS, Shen ZX. Primary study of leptin and human hepatocellular carcinoma in vitro. World J Gastroenterol. 2008; 14(18): 2900-4[PubMed]
  • 37. Yang R, Barouch LA. Leptin signaling and obesity: cardiovascular consequences. Circ Res. 2007; 101(6): 545-59[DOI][PubMed]
  • 38. Singh P, Hoffmann M, Wolk R, Shamsuzzaman AS, Somers VK. Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2007; 27(9)-7[DOI][PubMed]
  • 39. Abdul Wahab A, Maarafiya MM, Soliman A, Younes NB, Chandra P. Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control. J Allergy (Cairo). 2013; 2013: 654104[DOI][PubMed]
  • 40. Zivanovic SS, Saranac L, Kamenov B, Bjelakovic B, Petrovic S. Leptin levels in obese and non-obese children with asthma. Eur Respir J. 2011; 38
  • 41. Mahmoud AE, Omar MM, Abdelghaffar Hibah NA, Issa HA. Leptin hormone in obese and non-obese stable and exacerbated cases of chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc. 2015; 64(3): 557-65[DOI]
  • 42. El-Eshmawy MM, El-Adawy EH, Mousa AA, Zeidan AE, El-Baiomy AA, Abdel-Samie ER, et al. Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women. BMC Womens Health. 2011; 11: 1[DOI][PubMed]
  • 43. Yang P, Bamlet WR, Sun Z, Ebbert JO, Aubry MC, Krowka MJ, et al. Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk. Chest. 2005; 128(1): 445-52[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments