International Journal of Endocrinology and Metabolism

Published by: Kowsar

Effect of JYTK on Antioxidant Status and Inflammation in Patients With Type 2 Diabetes: A Randomized Double-Blind Clinical Trial

Yuan Hu 1 , Xin Zhou 1 , Dai-Hong Guo 1 , * and Ping Liu 1
Authors Information
1 Centre of Pharmacy, Chinese PLA General Hospital, Beijing, China
Article information
  • International Journal of Endocrinology and Metabolism: January 01, 2016, 14 (1); e34400
  • Published Online: January 30, 2016
  • Article Type: Research Article
  • Received: November 5, 2015
  • Revised: December 30, 2015
  • Accepted: January 11, 2016
  • DOI: 10.5812/ijem.34400

To Cite: Hu Y, Zhou X, Guo D, Liu P. Effect of JYTK on Antioxidant Status and Inflammation in Patients With Type 2 Diabetes: A Randomized Double-Blind Clinical Trial, Int J Endocrinol Metab. 2016 ; 14(1):e34400. doi: 10.5812/ijem.34400.

Copyright © 2016, Research Institute For Endocrine Sciences and Iran Endocrine Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Yang SH, Dou KF, Song WJ. Prevalence of diabetes among men and women in China. N Engl J Med. 2010; 362(25): 2425-6[PubMed]
  • 2. Murguia-Romero M, Jimenez-Flores JR, Sigrist-Flores SC, Espinoza-Camacho MA, Jimenez-Morales M, Pina E, et al. Plasma triglyceride/HDL-cholesterol ratio, insulin resistance, and cardiometabolic risk in young adults. J Lipid Res. 2013; 54(10): 2795-9[DOI][PubMed]
  • 3. Lim S, Eckel RH. Pharmacological treatment and therapeutic perspectives of metabolic syndrome. Rev Endocr Metab Disord. 2014; 15(4): 329-41[DOI][PubMed]
  • 4. Xie W, Zhao Y, Zhang Y. Traditional chinese medicines in treatment of patients with type 2 diabetes mellitus. Evid Based Complement Alternat Med. 2011; 2011: 726723[DOI][PubMed]
  • 5. Pooya S, Jalali MD, Jazayery AD, Saedisomeolia A, Eshraghian MR, Toorang F. The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutr Metab Cardiovasc Dis. 2010; 20(5): 326-31[DOI][PubMed]
  • 6. Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med. 2011; 50(5): 567-75[DOI][PubMed]
  • 7. Zozulinska D, Wierusz-Wysocka B. Type 2 diabetes mellitus as inflammatory disease. Diabetes Res Clin Pract. 2006; 74(2)-6[DOI]
  • 8. Garcia C, Feve B, Ferre P, Halimi S, Baizri H, Bordier L, et al. Diabetes and inflammation: fundamental aspects and clinical implications. Diabetes Metab. 2010; 36(5): 327-38[DOI][PubMed]
  • 9. Kim HG, Yoo SR, Park HJ, Lee NH, Shin JW, Sathyanath R, et al. Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial. Food Chem Toxicol. 2011; 49(9): 2229-35[DOI][PubMed]
  • 10. Jia W, Gao W, Tang L. Antidiabetic herbal drugs officially approved in China. Phytother Res. 2003; 17(10): 1127-34[DOI][PubMed]
  • 11. Ma SW, Benzie IF, Chu TT, Fok BS, Tomlinson B, Critchley LA. Effect of Panax ginseng supplementation on biomarkers of glucose tolerance, antioxidant status and oxidative stress in type 2 diabetic subjects: results of a placebo-controlled human intervention trial. Diabetes Obes Metab. 2008; 10(11): 1125-7[DOI][PubMed]
  • 12. Hao A, Chen L, Wang F, Jin D, Duan D. Effect of xiaokehuayu pills on blood glucose and lipid in diabetic rats [J]. Chinese J Health Care Med. 2008; 4: 19
  • 13. Fa Wei W, Ai Zhen H, Li Ping C, Dao Shan J, Dong Mei D. Effect of Xiaokehuayu Pills on blood glucose and superoxide dismutase activity of diabetic rats. China J Tradition Chinese Med Pharm. 2009; 24(8): 1089-91
  • 14. Hu Y, Zhou X, Liu P, Wang B, Duan D, Guo DH. A comparison study of metformin only therapy and metformin combined with Chinese medicine jianyutangkang therapy in patients with type 2 diabetes: A randomized placebo-controlled double-blind study. Complement Ther Med. 2016; 24: 13-8
  • 15. Lin B, Fan Y, Xiao-Lei W. Study on Quality Control of Xiaokehuayu Tablet. Pharm J Chinese People Liberat Army. 2006; 5
  • 16. Bai L, Xu Z, Ren W. Content determination of kaempferol in Jianyutangkang tablet by HPLC. Chinese J Drug Appl Monitor. 2011; 3: 9
  • 17. Bai Lin HA, Jin D, Xu YJ, Zhang H. Measurement of mangiferin level in Jianyu tangkang tablets with HPLC-UV. J Chinese PLA Postgrad Med School. 2011; 31: 1007-13
  • 18. Whiteside CI. Cellular mechanisms and treatment of diabetes vascular complications converge on reactive oxygen species. Curr Hypertens Rep. 2005; 7(2): 148-54[PubMed]
  • 19. Ghadge AA, Harke SM, Khadke SP, Diwan AG, Pankaj M, Kulkarni OP, et al. Circulatory adipocytokines and lipid profile variations in type-2 diabetic subjects: desirable side-effects of antidiabetic drugs. Diabetes Metab Syndr. 2014; 8(4): 230-2[DOI][PubMed]
  • 20. Chen W, Zhang Y, Li X, Yang G, Liu JP. Chinese herbal medicine for diabetic peripheral neuropathy. Cochrane Database Syst Rev. 2013; 10[DOI][PubMed]
  • 21. Wadden TA, Berkowitz RI, Womble LG, Sarwer DB, Phelan S, Cato RK, et al. Randomized trial of lifestyle modification and pharmacotherapy for obesity. N Engl J Med. 2005; 353(20): 2111-20[DOI][PubMed]
  • 22. Zhen Z, Chang B, Li M, Lian FM, Chen L, Dong L, et al. Anti-diabetic effects of a Coptis chinensis containing new traditional Chinese medicine formula in type 2 diabetic rats. Am J Chin Med. 2011; 39(1): 53-63[DOI][PubMed]
  • 23. Yin J, Zhang H, Ye J. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets. 2008; 8(2): 99-111[PubMed]
  • 24. Porta M, Molinatti P, La Selva M, Molinatti GM. [Endothelium and its morphofunctional changes in the pathogenesis of diabetic microangiopathy]. Minerva Med. 1988; 79(11): 915-29[PubMed]
  • 25. Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH, Yue KK. Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2006; 550(1-3): 173-9[DOI][PubMed]
  • 26. Kar P, Laight D, Rooprai HK, Shaw KM, Cummings M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. 2009; 26(5): 526-31[DOI][PubMed]
  • 27. Uemura T, Hirai S, Mizoguchi N, Goto T, Lee JY, Taketani K, et al. Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res. 2010; 54(11): 1596-608[DOI][PubMed]
  • 28. Yang XW, Liu FQ, Guo JJ, Yao WJ, Li QQ, Liu TH, et al. Antioxidation and anti-inflammatory activity of Tang Bi Kang in rats with diabetic peripheral neuropathy. BMC Complement Altern Med. 2015; 15: 66[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments