Correlations Between Changes in Undercarboxylated Osteocalcin and Muscle Function in Hypoparathyroidism

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To Cite : Harslof T, Sikjaer T, Mosekilde L, Langdahl B L, Rejnmark L. et al. Correlations Between Changes in Undercarboxylated Osteocalcin and Muscle Function in Hypoparathyroidism, Int J Endocrinol Metab. 2016 ;14(3):e38440. doi: 10.5812/ijem.38440.
Copyright: Copyright © 2016, International Journal of Endocrinology and Metabolism. .
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Edwards MH, Gregson CL, Patel HP, Jameson KA, Harvey NC, Sayer AA, et al. Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study. J Bone Miner Res. 2013; 28(11): 2295-304[DOI][PubMed]
  • 2. Nelson ME, Fiatarone MA, Morganti CM, Trice I, Greenberg RA, Evans WJ. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. JAMA. 1994; 272(24): 1909-14[PubMed]
  • 3. Rittweger J, Frost HM, Schiessl H, Ohshima H, Alkner B, Tesch P, et al. Muscle atrophy and bone loss after 90 days' bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study. Bone. 2005; 36(6): 1019-29[DOI][PubMed]
  • 4. Porter MM, Vandervoort AA, Lexell J. Aging of human muscle: structure, function and adaptability. Scand J Med Sci Sports. 1995; 5(3): 129-42[PubMed]
  • 5. Vico L, Prallet B, Chappard D, Pallot-Prades B, Pupier R, Alexandre C. Contributions of chronological age, age at menarche and menopause and of anthropometric parameters to axial and peripheral bone densities. Osteoporos Int. 1992; 2(3): 153-8[PubMed]
  • 6. Schoenau E. From mechanostat theory to development of the "Functional Muscle-Bone-Unit". J Musculoskelet Neuronal Interact. 2005; 5(3): 232-8[PubMed]
  • 7. Chen JH, Liu C, You L, Simmons CA. Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone. J Biomech. 2010; 43(1): 108-18[DOI][PubMed]
  • 8. Civitelli R. Cell-cell communication in the osteoblast/osteocyte lineage. Arch Biochem Biophys. 2008; 473(2): 188-92[DOI][PubMed]
  • 9. Shen H, Grimston S, Civitelli R, Thomopoulos S. Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice. J Bone Miner Res. 2015; 30(4): 596-605[DOI][PubMed]
  • 10. Levinger I, Scott D, Nicholson GC, Stuart AL, Duque G, McCorquodale T, et al. Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women. Bone. 2014; 64: 8-12[DOI][PubMed]
  • 11. Sikjaer T, Rejnmark L, Rolighed L, Heickendorff L, Mosekilde L, Hypoparathyroid Study G. The effect of adding PTH(1-84) to conventional treatment of hypoparathyroidism: a randomized, placebo-controlled study. J Bone Miner Res. 2011; 26(10): 2358-70[DOI][PubMed]
  • 12. Harslof T, Sikjaer T, Sorensen L, Pedersen SB, Mosekilde L, Langdahl BL, et al. The Effect of Treatment With PTH on Undercarboxylated Osteocalcin and Energy Metabolism in Hypoparathyroidism. J Clin Endocrinol Metab. 2015; 100(7): 2758-62[DOI][PubMed]
  • 13. Sikjaer T, Rolighed L, Hess A, Fuglsang-Frederiksen A, Mosekilde L, Rejnmark L. Effects of PTH(1-84) therapy on muscle function and quality of life in hypoparathyroidism: results from a randomized controlled trial. Osteoporos Int. 2014; 25(6): 1717-26[DOI][PubMed]
  • 14. Curb JD, Ceria-Ulep CD, Rodriguez BL, Grove J, Guralnik J, Willcox BJ, et al. Performance-based measures of physical function for high-function populations. J Am Geriatr Soc. 2006; 54(5): 737-42[DOI][PubMed]
  • 15. Era P, Sainio P, Koskinen S, Haavisto P, Vaara M, Aromaa A. Postural balance in a random sample of 7,979 subjects aged 30 years and over. Gerontology. 2006; 52(4): 204-13[DOI][PubMed]
  • 16. Syriou V, Kolitsa A, Pantazi L, Pikazis D. Hypoparathyroidism in a patient presenting with severe myopathy and skin rash. Case report and review of the literature. Hormones (Athens). 2005; 4(3): 161-4[PubMed]
  • 17. Yamaguchi H, Okamoto K, Shooji M, Morimatsu M, Hirai S. Muscle histology of hypocalcaemic myopathy in hypoparathyroidism. J Neurol Neurosurg Psychiatry. 1987; 50(6): 817-8[PubMed]
  • 18. Morris GS, Landry CL, Grubbs EG, Jimenez C, Busaidy NL, Perrier ND. Greater than age-predicted functional deficits in older patients with primary hyperparathyroidism. Endocr Pract. 2012; 18(4): 450-5[DOI][PubMed]
  • 19. Moreira-Pfrimer LD, Pedrosa MA, Teixeira L, Lazaretti-Castro M. Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab. 2009; 54(4): 291-300[DOI][PubMed]
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