Worldwide Recall Rate in Newborn Screening Programs for Congenital Hypothyroidism

Authors Information
Article Notes and Dates
To Cite : Mehran L, Khalili D, Yarahmadi S, Amouzegar A, Mojarrad M, et al. Worldwide Recall Rate in Newborn Screening Programs for Congenital Hypothyroidism, Int J Endocrinol Metab. 2017 ;15(3):e55451. doi: 10.5812/ijem.55451.
Copyright: Copyright © 2017, International Journal of Endocrinology and Metabolism. .
Abstract
1. Context
2. Method of Data Source and Selection Criteria
3. Definitions
4. Results
5. Iodine Deficiency
6. Different Strategies
7. Lowering Cut Off
8. Laboratory Methods
9. Iodinated Disinfectants
10. Site of Sample Collection
11. CH Incidence
12. Human Error
13. Conclusions
Footnotes
References
  • 1. Grosse SD, Van Vliet G. Prevention of intellectual disability through screening for congenital hypothyroidism: how much and at what level? Arch Dis Child. 2011; 96(4): 374-9[DOI][PubMed]
  • 2. Gruters A, Jenner A, Krude H. Long-term consequences of congenital hypothyroidism in the era of screening programmes. Best Pract Res Clin Endocrinol Metab. 2002; 16(2): 369-82[DOI][PubMed]
  • 3. Van Vliet G. Treatment of congenital hypothyroidism. Lancet. 2001; 358(9276): 86-7[DOI][PubMed]
  • 4. Fisher DA, Dussault JH, Foley TJ, Klein AH, LaFranchi S, Larsen PR, et al. Screening for congenital hypothyroidism: results of screening one million North American infants. J Pediatr. 1979; 94(5): 700-5[PubMed]
  • 5. Dussault JH. The anecdotal history of screening for congenital hypothyroidism. J Clin Endocrinol Metab. 1999; 84(12): 4332-4[DOI][PubMed]
  • 6. Klett M. Epidemiology of congenital hypothyroidism. Exp Clin Endocrinol Diabetes. 1997; 105 Suppl 4: 19-23[DOI][PubMed]
  • 7. Harris KB, Pass KA. Increase in congenital hypothyroidism in New York State and in the United States. Mol Genet Metab. 2007; 91(3): 268-77[DOI][PubMed]
  • 8. Larson C, Hermos R, Rojas D. Rising incidence of congenital hypothyroidism detected by primary T4 screening in Massachusetts. Proceedings 4th Meeting of the International Society for Neonatal Screening. 1999;
  • 9. Corbetta C, Weber G, Cortinovis F, Calebiro D, Passoni A, Vigone MC, et al. A 7-year experience with low blood TSH cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism (CH). Clin Endocrinol (Oxf). 2009; 71(5): 739-45[DOI][PubMed]
  • 10. Kurinczuk JJ, Bower C, Lewis B, Byrne G. Congenital hypothyroidism in Western Australia 1981-1998. J Paediatr Child Health. 2002; 38(2): 187-91[PubMed]
  • 11. Kaiserman I, Siebner R, Kletter G, Sack J. A ten-year temporal analysis of primary congenital hypothyroidism in Israel. Early Hum Dev. 1991; 26(3): 193-201[PubMed]
  • 12. Rose SR, Brown RS, Foley T, Kaplowitz PB, Kaye CI, et al. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics. 2006; 117(6): 2290-303[DOI][PubMed]
  • 13. Allen DB, Farrell PM. Newborn screening: principles and practice. Adv Pediatr. 1996; 43: 231-70[PubMed]
  • 14. Sackett DLHR, Tugwell P. Clinical Epidemiology: A Basic Science for Clinical Medicine. 1985;
  • 15. Chanoine JP, Pardou A, Bourdoux P, Delange F. Withdrawal of iodinated disinfectants at delivery decreases the recall rate at neonatal screening for congenital hypothyroidism. Arch Dis Child. 1988; 63(10): 1297-8[PubMed]
  • 16. Harris P, Dreyfus NG. Newborn thyroid screening in a municipal hospital. Am J Dis Child. 1982; 136(3): 248-50[PubMed]
  • 17. Walfish PG. Evaluation of three thyroid-function screening tests for detecting neonatal hypothyroidism. Lancet. 1976; 1(7971): 1208-10[PubMed]
  • 18. Wu LL, Sazali BS, Adeeb N, Khalid BA. Congenital hypothyroid screening using cord blood TSH. Singapore Med J. 1999; 40(1): 23-6[PubMed]
  • 19. Dussault JH, Morissette J. Higher sensitivity of primary thyrotropin in screening for congenital hypothyroidism: a myth? J Clin Endocrinol Metab. 1983; 56(4): 849-52[DOI][PubMed]
  • 20. Ordoukhani A, Mirsaiid Ghazi AA, Hajipour R, Mirmiran P, Hedayati M, Azizi F. Screening for congenital hypothyroidism: before and after iodine supplementation in Iran. Iran J Endocrinol Metabo. 2000; 2(2): 93-8
  • 21. Karamizadeh Z, Amirhakimi GH. Incidence of congenital hypothyroidism in Fars Province, Iran. Iran J Med Sci. 1992; 17(1-2): 78-80
  • 22. Azizi F, Sheikholeslam R, Hedayati M, Mirmiran P, Malekafzali H, Kimiagar M, et al. Sustainable control of iodinedeficiency in Iran: beneficial results of the implementation of the mandatory law on salt iodization. J Endocrinol Invest. 2002; 25(5): 409-13[DOI][PubMed]
  • 23. Karamizadeh Z, Saneifard H, Amirhakimi G, Karamifar H, Alavi M. Evaluation of congenital hypothyroidism in fars province, iran. Iran J Pediatr. 2012; 22(1): 107-12[PubMed]
  • 24. Delange F, Burgi H, Chen ZP, Dunn JT. World status of monitoring iodine deficiency disorders control programs. Thyroid. 2002; 12(10): 915-24[DOI][PubMed]
  • 25. Delange F, de Benoist B, Pretell E, Dunn JT. Iodine deficiency in the world: where do we stand at the turn of the century? Thyroid. 2001; 11(5): 437-47[DOI][PubMed]
  • 26. Hollowell JG, Staehling NW, Hannon WH, Flanders DW, Gunter EW, Maberly GF, et al. Iodine nutrition in the United States. Trends and public health implications: iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-1974 and 1988-1994). J Clin Endocrinol Metab. 1998; 83(10): 3401-8[DOI][PubMed]
  • 27. Glinoer D. Pregnancy and iodine. Thyroid. 2001; 11(5): 471-81[DOI][PubMed]
  • 28. Fisher DA. Clinical pediatric and adolescent endocrinology. 2002;
  • 29. Buyukgebiz A. Newborn screening for congenital hypothyroidism. J Clin Res Pediatr Endocrinol. 2013; 5 Suppl 1: 8-12[DOI][PubMed]
  • 30. American Academy of Pediatrics AAP Section on Endocrinology and Committee on Genetics, and American Thyroid Association Committee on Public Health: Newborn screening for congenital hypothyroidism: recommended guidelines. Pediatrics. 1993; 91(6): 1203-9[PubMed]
  • 31. Standard A. Blood Collection on Filter Paper for Neonatal Screening Programs. 1992;
  • 32. Berardi R, Baracchi MR, Borgogni P, Margollicci MA, Mattei R, Fois A. [Results of a screening project for congenital hypothyroidism in 4 years of experience]. Pediatr Med Chir. 1982; 4(6): 657-60[PubMed]
  • 33. Amini M, Hashemipour M, Iranpour R, Hovsepian S, Haghighi S, Khatibi K. Rate of recalls in congenital hypothyroidism based upon a regional survey in Isfahan, Iran, using serum T4 and TSH analyses: comparison of two different recall methods. Horm Res. 2005; 64(6): 287-92[DOI][PubMed]
  • 34. Najafi M, Farsi MM, Sabahi M. Primary blood TSH/back up TSH measurements: an improved approach for neonatal thyroid screening. J Clin Lab Anal. 2011; 25(1): 61-3[DOI][PubMed]
  • 35. Najafi M, Khodaee GH, Bahari M, Sabahi M, Farsi MM, Kiani F. Neonatal thyroid screening in a mild iodine deficiency endemic area in Iran. Indian J Med Sci. 2008; 62(3): 113-6[PubMed]
  • 36. Pryce RA, Gregory JW, Warner JT, John R, Bradley D, Evans C. Is the current threshold level for screening for congenital hypothyroidism too high? An audit of the clinical evaluation, confirmatory diagnostic tests and treatment of infants with increased blood spot thyroid-stimulating hormone concentrations identified on newborn blood spot screening in Wales. Arch Dis Child. 2007; 92(11): 1048[DOI][PubMed]
  • 37. Alm J, Hagenfeldt L, Larsson A, Lundberg K. Incidence of congenital hypothyroidism: retrospective study of neonatal laboratory screening versus clinical symptoms as indicators leading to diagnosis. Br Med J (Clin Res Ed). 1984; 289(6453): 1171-5[PubMed]
  • 38. Korada M, Pearce MS, Ward Platt MP, Avis E, Turner S, Wastell H, et al. Repeat testing for congenital hypothyroidism in preterm infants is unnecessary with an appropriate thyroid stimulating hormone threshold. Arch Dis Child Fetal Neonatal Ed. 2008; 93(4)-8[DOI][PubMed]
  • 39. Korada SM, Pearce M, Ward Platt MP, Avis E, Turner S, Wastell H, et al. Difficulties in selecting an appropriate neonatal thyroid stimulating hormone (TSH) screening threshold. Arch Dis Child. 2010; 95(3): 169-73[DOI][PubMed]
  • 40. Dluholucky S, Hornova V, Bucek M, Langer P. Studies on congenital hypothyroidism and results of three and half years of compulsory screening program in Slovak Socialist Republic. Endocrinol Exp. 1989; 23(2): 125-35[PubMed]
  • 41. Heyerdahl S, Oerbeck B. Congenital hypothyroidism: developmental outcome in relation to levothyroxine treatment variables. Thyroid. 2003; 13(11): 1029-38[DOI][PubMed]
  • 42. Murphy N, Hume R, van Toor H, Matthews TG, Ogston SA, Wu SY, et al. The hypothalamic-pituitary-thyroid axis in preterm infants; changes in the first 24 hours of postnatal life. J Clin Endocrinol Metab. 2004; 89(6): 2824-31[DOI][PubMed]
  • 43. Allen DB, Sieger JE, Litsheim T, Duck SC. Age-adjusted thyrotropin criteria for neonatal screening for hypothyroidism. J Pediatr. 1990; 117(2 Pt 1): 309-12[PubMed]
  • 44. Francis I, Weldon A, Connelly J. Effect of Betadine treatment to umbilical cords on screening tests for congenital hypothyroidism. 1983;
  • 45. Grüters A, Lallemend D, Heideman P, Helge H. Thyroid function and iodine concentrations in newborns and their mothers after vaginal PVP-iodine treatment in obstetrics. 1983;
  • 46. Chanoine JP, Boulvain M, Bourdoux P, Pardou A, Van Thi HV, Ermans AM, et al. Increased recall rate at screening for congenital hypothyroidism in breast fed infants born to iodine overloaded mothers. Arch Dis Child. 1988; 63(10): 1207-10[PubMed]
  • 47. Harada S, Ichihara N, Arai J, Honma H, Matsuura N, Fujieda K. Influence of iodine excess due to iodine-containing antiseptics on neonatal screening for congenital hypothyroidism in Hokkaido prefecture, Japan. Screening. 1994; 3(3): 115-23[DOI]
  • 48. Ordookhani A, Pearce EN, Mirmiran P, Azizi F, Braverman LE. The effect of type of delivery and povidone-iodine application at delivery on cord dried-blood-specimen thyrotropin level and the rate of hyperthyrotropinemia in mature and normal-birth-weight neonates residing in an iodine-replete area: report of Tehran Province, 1998-2005. Thyroid. 2007; 17(11): 1097-102[DOI][PubMed]
  • 49. Lin CP, Chen W, Wu KW. Povidone-iodine in umbilical cord care interferes with neonatal screening for hypothyroidism. Eur J Pediatr. 1994; 153(10): 756-8[PubMed]
  • 50. Nohr SB, Laurberg P. Opposite variations in maternal and neonatal thyroid function induced by iodine supplementation during pregnancy. J Clin Endocrinol Metab. 2000; 85(2): 623-7[DOI][PubMed]
  • 51. Weber G, Vigone MC, Rapa A, Bona G, Chiumello G. Neonatal transient hypothyroidism: aetiological study. Italian Collaborative Study on Transient Hypothyroidism. Arch Dis Child Fetal Neonatal Ed. 1998; 79(1)-2[PubMed]
  • 52. Cassio A, Colli C, Piazzi S, Bozza D, Zappulla F, Balsamo A, et al. [Results of screening of congenital hypothyroidism and iodine excess in neonatal age]. Ann Ist Super Sanita. 1998; 34(3): 337-41[PubMed]
  • 53. Koga Y, Sano H, Kikukawa Y, Ishigouoka T, Kawamura M. Effect on neonatal thyroid function of povidone-iodine used on mothers during perinatal period. J Obstet Gynaecol (Tokyo 1995). 1995; 21(6): 581-5[PubMed]
  • 54. Brown RS, Bloomfield S, Bednarek FJ, Mitchell ML, Braverman LE. Routine skin cleansing with povidone-iodine is not a common cause of transient neonatal hypothyroidism in North America: a prospective controlled study. Thyroid. 1997; 7(3): 395-400[DOI][PubMed]
  • 55. Caldwell KL, Pan Y, Mortensen ME, Makhmudov A, Merrill L, Moye J. Iodine status in pregnant women in the National Children's Study and in U.S. women (15-44 years), National Health and Nutrition Examination Survey 2005-2010. Thyroid. 2013; 23(8): 927-37[DOI][PubMed]
  • 56. Hashemipour M, Nasri P, Hovsepian S, Hadian R, Heidari K, Attar HM, et al. Urine and milk iodine concentrations in healthy and congenitally hypothyroid neonates and their mothers. Endokrynol Pol. 2010; 61(4): 371-6[PubMed]
  • 57. Hashemipour M, Amini M, Iranpour R, Sadri GH, Javaheri N, Haghighi S, et al. Prevalence of congenital hypothyroidism in Isfahan, Iran: results of a survey on 20,000 neonates. Horm Res. 2004; 62(2): 79-83[DOI][PubMed]
  • 58. Manglik AK, Chatterjee N, Ghosh G. Umbilical cord blood TSH levels in term neonates: a screening tool for congenital hypothyroidism. Indian Pediatr. 2005; 42(10): 1029-32[PubMed]
  • 59. Elbualy M, Bold A, De Silva V, Gibbons U. Congenital hypothyroid screening: the Oman experience. J Trop Pediatr. 1998; 44(2): 81-3[PubMed]
  • 60. Majeed-Saidan MA, Joyce B, Khan M, Hamam HD. Congenital hypothyroidism: the Riyadh Military Hospital experience. Clin Endocrinol (Oxf). 1993; 38(2): 191-5[PubMed]
  • 61. Joseph R, Aw TC, Tan KL. Free thyroxine as a supplement to thyrotropin in cord screening for hypothyroidism. Ann Acad Med Singapore. 1993; 22(4): 549-52[PubMed]
  • 62. Fuse Y, Wakae E, Nemoto Y, Uga N, Tanaka M, Maeda M, et al. Influence of perinatal factors and sampling methods on TSH and thyroid hormone levels in cord blood. Endocrinol Jpn. 1991; 38(3): 297-302[PubMed]
  • 63. Ain A, Dhabi A. Cord blood thyroxine and thyroid stimulating hormone screening for congenital hypothyroidism: how useful are they? J Pediatr Endocrinol Metab. 2008; 21: 245-9
  • 64. Vulsma T, Gons MH, de Vijlder JJ. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N Engl J Med. 1989; 321(1): 13-6[DOI][PubMed]
  • 65. Zamboni G, Zaffanello M, Rigon F, Radetti G, Gaudino R, Tato L. Diagnostic effectiveness of simultaneous thyroxine and thyroid-stimulating hormone screening measurements. Thirteen years' experience in the Northeast Italian Screening Programme. J Med Screen. 2004; 11(1): 8-10[DOI][PubMed]
  • 66. Albert BB, Cutfield WS, Webster D, Carll J, Derraik JG, Jefferies C, et al. Etiology of increasing incidence of congenital hypothyroidism in New Zealand from 1993-2010. J Clin Endocrinol Metab. 2012; 97(9): 3155-60[DOI][PubMed]
  • 67. Medda E, Olivieri A, Stazi MA, Grandolfo ME, Fazzini C, Baserga M, et al. Risk factors for congenital hypothyroidism: results of a population case-control study (1997-2003). Eur J Endocrinol. 2005; 153(6): 765-73[DOI][PubMed]
  • 68. Mitchell ML, Hsu HW, Sahai I, Massachusetts Pediatric Endocrine Work G. The increased incidence of congenital hypothyroidism: fact or fancy? Clin Endocrinol (Oxf). 2011; 75(6): 806-10[DOI][PubMed]
  • 69. Hinton CF, Harris KB, Borgfeld L, Drummond-Borg M, Eaton R, Lorey F, et al. Trends in incidence rates of congenital hypothyroidism related to select demographic factors: data from the United States, California, Massachusetts, New York, and Texas. Pediatrics. 2010; 125 Suppl 2-47[DOI][PubMed]
  • 70. Olivieri A, Medda E, De Angelis S, Valensise H, De Felice M, Fazzini C, et al. High risk of congenital hypothyroidism in multiple pregnancies. J Clin Endocrinol Metab. 2007; 92(8): 3141-7[DOI][PubMed]
  • 71. Scriver CR. Phenylketonuria--genotypes and phenotypes. N Engl J Med. 1991; 324(18): 1280-1[DOI][PubMed]
  • 72. Khoury MJ. From genes to public health: the applications of genetic technology in disease prevention. Genetics Working Group. Am J Public Health. 1996; 86(12): 1717-22[PubMed]
  • 73. Dussault JH, Coulombe P, Laberge C, Letarte J, Guyda H, Khoury K. Preliminary report on a mass screening program for neonatal hypothyroidism. J Pediatr. 1975; 86(5): 670-4[PubMed]
  • 74. Travis JC, Dungy CI, Huxtable RF, Valenta LJ. Methods of quality control and clinical evaluation of a commercial thyroxine and thyrotropin assay for use in neonates. Clin Chem. 1979; 25(5): 735-40[PubMed]
  • 75. Antonozzi I, Dominici R, Andreoli M, Monaco F. Neonatal screening in Italy for congenital hypothyroidism and metabolic disorders: hyperphenylalaninemia, maple syrup urine disease and homocystinuria. J Endocrinol Invest. 1980; 3(4): 357-63[DOI][PubMed]
  • 76. Low LC, Lin HJ, Cheung PT, Lee FT, Chu SY, Kwok TL, et al. Screening for congenital hypothyroidism in Hong Kong. Aust Paediatr J. 1986; 22(1): 53-6[PubMed]
  • 77. Pharoah PO, Madden MP. Audit of screening for congenital hypothyroidism. Arch Dis Child. 1992; 67(9): 1073-6[PubMed]
  • 78. Yordam N, Calikoglu AS, Hatun S, Kandemir N, Oguz H, Tezic T, et al. Screening for congenital hypothyroidism in Turkey. Eur J Pediatr. 1995; 154(8): 614-6[PubMed]
  • 79. Costante G, Grasso L, Ludovico O, Marasco MF, Nocera M, Schifino E, et al. The statistical analysis of neonatal TSH results from congenital hypothyroidism screening programs provides a useful tool for the characterization of moderate iodine deficiency regions. J Endocrinol Invest. 1997; 20(5): 251-6[DOI][PubMed]
  • 80. Kwon C, Farrell PM. The magnitude and challenge of false-positive newborn screening test results. Arch Pediatr Adolesc Med. 2000; 154(7): 714-8[PubMed]
  • 81. Joseph R. Mass newborn screening in Singapore. Southeast Asian J Trop Med Public Health. 2003; 34 Suppl 3: 89-90[PubMed]
  • 82. Mikelsaar RV, Zordania R, Viikmaa M, Kudrjavtseva G. Neonatal screening for congenital hypothyroidism in Estonia. J Med Screen. 1998; 5(1): 20-1[DOI][PubMed]
  • 83. Mahachoklertwattana P, Phuapradit W, Siripoonya P, Charoenpol O, Thuvasethakul P, Rajatanavin R. Five-year thyrotropin screening for congenital hypothyroidism in Ramathibodi Hospital. J Med Assoc Thailand. 1999; 82-32
  • 84. Ordookhani A, Mirmiran P, Hedayati M, Hajipour R, Azizi F. An interim report of the pilot study of screening for congenital hypothyroidism in Tehran and Damavand using cord blood spot samples. Eur J Pediatr. 2003; 162(3): 202-3[DOI][PubMed]
  • 85. Panamonta O, Tuksapun S, Kiatchoosakun P, Jirapradittha J, Kirdpon W, Loapaiboon M. Newborn screening for congenital hypothyroidism in Khon Kaen University Hospital, the first three years, a preliminary report. J Med Assoc Thailand. 2003; 86(10): 932-7
  • 86. Simsek E, Karabay M, Kocabay K. Neonatal screening for congenital hypothyroidism in West Black Sea area, Turkey. Int J Clin Pract. 2005; 59(3): 336-41[DOI][PubMed]
  • 87. Ng SM, Wong SC, Isherwood DM, Smith CS, Didi M. Multivariate analysis on factors affecting suppression of thyroid-stimulating hormone in treated congenital hypothyroidism. Horm Res. 2004; 62(5): 245-51[DOI][PubMed]
  • 88. Dabbous NI, Abd El-Aziz HM, Abou El-Enein NY, Kandil HH, El-Kafoury AA. Indicators of the screening program for congenital hypothyroidism in alexandria. J Egypt Public Health Assoc. 2008; 83(3-4): 307-27[PubMed]
  • 89. Zaffanello M, Maffeis C, Zamboni G. Multiple positive results during a neonatal screening program: a retrospective analysis of incidence, clinical implications and outcomes. J Perinat Med. 2005; 33(3): 246-51[DOI][PubMed]
  • 90. Rendon-Macias ME, Morales-Garcia I, Huerta-Hernandez E, Silva-Batalla A, Villasis-Keever MA. Birth prevalence of congenital hypothyroidism in Mexico. Paediatr Perinat Epidemiol. 2008; 22(5): 478-85[DOI][PubMed]
  • 91. Kreisner E, Vargas P, Stein A, Gross JL, Guerreiro Moreira MD, Goldbeck AS. A strategy to avoid missed cases in a Brazilian neonatal TSH screening program for congenital hypothyroidism. J Pediatr Endocrinol. 2009; 22(5): 443
  • 92. Zarina AL, Rahmah R, Bador KM, Ng SF, Wu LL. Audit of newborn screening programme for congenital hypothyroidism. Med J Malaysia. 2008; 63(4): 325-8[PubMed]
  • 93. Ogunkeye OO, Roluga AI, Khan FA. Resetting the detection level of cord blood thyroid stimulating hormone (TSH) for the diagnosis of congenital hypothyroidism. J Trop Pediatr. 2008; 54(1): 74-7[DOI][PubMed]
  • 94. Hasan M, Nahar N, Moslem F, Begum NA. Newborn screening in Bangladesh. Ann Acad Med Singapore. 2008; 37(12 Suppl): 111-3[PubMed]
  • 95. Zhan JY, Qin YF, Zhao ZY. Neonatal screening for congenital hypothyroidism and phenylketonuria in China. World J Pediatr. 2009; 5(2): 136-9[DOI][PubMed]
  • 96. Tahirovic H, Toromanovic A. Neonatal screening for congenital hypothyroidism in the Federation of Bosnia and Herzegovina: eight years' experience. Eur J Pediatr. 2009; 168(5): 629-31[DOI][PubMed]
  • 97. Gjurkova B, Anastasovska V, Sukarova Angelovska E, Kocova M. Methodological and organizational aspects of newborn screening for congenital hypothyroidism in Macedonia. Prilozi. 2008; 29(1): 93-106[PubMed]
  • 98. Afroze B, Humayun KN, Qadir M. Newborn screening in Pakistan - lessons from a hospital-based congenital hypothyroidism screening programme. Ann Acad Med Singapore. 2008; 37(12 Suppl): 114-3[PubMed]
  • 99. Majid V, Saeideh M, Ali N, Zahra S. High Incidence and Recall Rate of Congenital Hypothyroidism in Zanjan Province, a Health Problem or a Study Challenge? Int J Endocrinol Metabo. 2011; 2011(4, Autumn): 338-42
  • 100. Hashemipour M, Dehkordi EH, Hovsepian S, Amini M, Hosseiny L. Outcome of congenitally hypothyroid screening program in isfahan: iran from prevention to treatment. Int J Prev Med. 2010; 1(2): 92-7[PubMed]
  • 101. Kusdal Y, Yesiltepe-Mutlu G, Ozsu E, Cizmecioglu FM, Hatun S. Congenital hypothyroidism screening program in Turkey: a local evaluation. Turk J Pediatr. 2012; 54(6): 590-5[PubMed]
  • 102. Dilli D, Czbas S, Acican D, Yamak N, Ertek M, Dilmen U. Establishment and development of a national newborn screening programme for congenital hypothyroidism in Turkey. J Clin Res Pediatr Endocrinol. 2013; 5(2): 73-9[DOI][PubMed]
  • 103. Gopalakrishnan V, Joshi K, Phadke S, Dabadghao P, Agarwal M, Das V, et al. Newborn screening for congenital hypothyroidism, galactosemia and biotinidase deficiency in Uttar Pradesh, India. Indian Pediatr. 2014; 51(9): 701-5[PubMed]
  • 104. Hettiarachchi M, Amarasena S. Indicators of newborn screening for congenital hypothyroidism in Sri Lanka: program challenges and way forward. BMC Health Serv Res. 2014; 14: 385[DOI][PubMed]
  • 105. Dorreh F, Chaijan PY, Javaheri J, Zeinalzadeh AH. Epidemiology of congenital hypothyroidism in Markazi Province, Iran. J Clin Res Pediatr Endocrinol. 2014; 6(2): 105-10[DOI][PubMed]
  • 106. Kocova M, Anastasovska V, Sukarova-Angelovska E, Tanaskoska M, Taseva E. Clinical practice: experience with newborn screening for congenital hypothyroidism in the Republic of Macedonia - a multiethnic country. Eur J Pediatr. 2015; 174(4): 443-8[DOI][PubMed]
  • 107. Veisani Y, Sayehmiri K, Rezaeian S, Delpisheh A. Congenital hypothyroidism screening program in iran; a systematic review and metaanalysis. Iran J Pediatr. 2014; 24(6): 665-72[PubMed]
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