International Journal of Endocrinology and Metabolism

Published by: Kowsar

Hypercalcaemic Pancreatitis, Adrenal Insufficiency, Autoimmune Thyroiditis and Diabetes Mellitus in a girl with Probable Sarcoidosis

Devi Dayal 1 , Olivia Pepper 1 , Renuka Ramakrishnan 1 , Eileen Baildam 2 , Poonam Dharmaraj 1 , Gavin Cleary 2 , Liza McCann 2 , Clare Pain 2 and Senthil Senniappan 1 , *
Authors Information
1 Department of Paediatric Endocrinology, Alder Hey Children’s Hospital, Liverpool, UK
2 Department of Paediatric Rheumatology, Alder Hey Children’s Hospital, Liverpool, UK
Article information
  • International Journal of Endocrinology and Metabolism: October 2017, 15 (4); e57199
  • Published Online: August 22, 2017
  • Article Type: Case Report
  • Received: April 5, 2017
  • Revised: July 22, 2017
  • Accepted: July 25, 2017
  • DOI: 10.5812/ijem.57199

To Cite: Dayal D, Pepper O, Ramakrishnan R, Baildam E, Dharmaraj P, et al. Hypercalcaemic Pancreatitis, Adrenal Insufficiency, Autoimmune Thyroiditis and Diabetes Mellitus in a girl with Probable Sarcoidosis, Int J Endocrinol Metab. 2017 ; 15(4):e57199. doi: 10.5812/ijem.57199.

Copyright © 2017, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Prasse A. The Diagnosis, Differential Diagnosis, and Treatment of Sarcoidosis. Dtsch Arztebl Int. 2016; 113(33-34): 565-74[DOI][PubMed]
  • 2. Wessendorf TE, Bonella F, Costabel U. Diagnosis of Sarcoidosis. Clin Rev Allergy Immunol. 2015; 49(1): 54-62[DOI][PubMed]
  • 3. Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007; 357(21): 2153-65[DOI][PubMed]
  • 4. Khan AH, Ghani F, Khan A, Khan MA, Khurshid M. Role of serum angiotensin converting enzyme in sarcoidosis. J Pak Med Assoc. 1998; 48(5): 131-3[PubMed]
  • 5. Cozier YC. Assessing the worldwide epidemiology of sarcoidosis: challenges and future directions. Eur Respir J. 2016; 48(6): 1545-8[DOI][PubMed]
  • 6. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Muller-Quernheim J. Sarcoidosis. Lancet. 2014; 383(9923): 1155-67[DOI][PubMed]
  • 7. Diaz Angarita T, Morales Camacho W, Lozano Neira L, Plata Ortiz J, Zarate Taborda L. [Systemic sarcoidosis: a diagnostic challenge in pediatrics. Case report]. Arch Argent Pediatr. 2016; 114(5)-8[DOI][PubMed]
  • 8. Saidha S, Sotirchos ES, Eckstein C. Etiology of sarcoidosis: does infection play a role? Yale J Biol Med. 2012; 85(1): 133-41[PubMed]
  • 9. Papadopoulos KI, Hornblad Y, Liljebladh H, Hallengren B. High frequency of endocrine autoimmunity in patients with sarcoidosis. Eur J Endocrinol. 1996; 134(3): 331-6[PubMed]
  • 10. Cagatay T, Bilir M, Gulbaran M, Papila C, Cagatay P. The immunoglobulin and complement levels in the active pulmonary sarcoidosis. Kobe J Med Sci. 2003; 49(5-6): 99-106[PubMed]
  • 11. Aujla K, Majithia V, Green A. Extreme hypercalcemia leading to the diagnosis of extensive sarcoidosis. J Clin Rheumatol. 2014; 20(6): 328-9[DOI][PubMed]
  • 12. Sharma OP, Vucinic V. Sarcoidosis of the thyroid and kidneys and calcium metabolism. Semin Respir Crit Care Med. 2002; 23(6): 579-88[DOI][PubMed]
  • 13. Amrein K, Schilcher G, Fahrleitner-Pammer A. Hypercalcaemia in asymptomatic sarcoidosis unmasked by a vitamin D loading dose. Eur Respir J. 2011; 37(2): 470-1[DOI][PubMed]
  • 14. Delakidis S, Elezoglou A. Hypercalcemia, hyperlipidemia and rheumatic diseases: uncommon causes inducing acute pancreatitis. Ann Gastroenterol. 2007; 13(2)
  • 15. Boruchowicz A, Hachulla E, Cortot A, Paris JC, Colombel JF. Chronic pancreatitis: a complication of sarcoidosis? Eur J Gastroenterol Hepatol. 1996; 8(11): 1125-7[PubMed]
  • 16. Nitsche C, Maertin S, Scheiber J, Ritter CA, Lerch MM, Mayerle J. Drug-induced pancreatitis. Curr Gastroenterol Rep. 2012; 14(2): 131-8[DOI][PubMed]
  • 17. Yoshioka K. Association of sarcoidosis, insulin-dependent diabetes mellitus, and ulcerative colitis. Arch Intern Med. 1997; 157(4): 465[DOI]
  • 18. Sanchez-Lozada R, Soriano-Rosas J, Gutierrez-Vega R. [Acute pancreatitis, diabetes, and sacoidosis. Case report and review of the literature]. Gac Med Mex. 2004; 140(3): 343-5[PubMed]
  • 19. Alsahwi N, Blavo D, Karanchi H. Systemic sarcoidosis with hypercalcaemia, hypothalamic-pituitary dysfunction and thyroid involvement. BMJ Case Rep. 2016; 2016[DOI][PubMed]
  • 20. Raisingani M, Preneet B, Kohn B, Yakar S. Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis. Growth Horm IGF Res. 2017; 34: 13-21[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments