International Journal of Endocrinology and Metabolism

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The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer

Reza Afrisham 1 , * , Maliheh Paknejad 1 , Omid Soliemanifar 2 , Sahar Sadegh-Nejadi 1 , Reza Meshkani 1 and Damoon Ashtary-Larky 3 , 4
Authors Information
1 Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 General Department of Education in Khuzestan Province, Department of Education in the City of Khorramshahr, Khorramshahr, Iran
3 Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • International Journal of Endocrinology and Metabolism: April 30, 2019, 17 (2); e67400
  • Published Online: April 20, 2019
  • Article Type: Review Article
  • Received: February 12, 2018
  • Revised: January 27, 2019
  • Accepted: February 25, 2019
  • DOI: 10.5812/ijem.67400

To Cite: Afrisham R, Paknejad M, Soliemanifar O, Sadegh-Nejadi S, Meshkani R, et al. The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer, Int J Endocrinol Metab. 2019 ; 17(2):e67400. doi: 10.5812/ijem.67400.

Abstract
Copyright © 2019, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Objectives
3. Evidence Acquisition
4. Results
5. Conclusions
Footnotes
References
  • 1. Soliemanifar O, Soleymanifar A, Afrisham R. Relationship between personality and biological reactivity to stress: A review. Psychiatry Investig. 2018;15(12):1100-14. doi: 10.30773/pi.2018.10.14.2. [PubMed: 30602103]. [PubMed Central: PMC6318487].
  • 2. Karavanaki K, Tsoka E, Liacopoulou M, Karayianni C, Petrou V, Pippidou E, et al. Psychological stress as a factor potentially contributing to the pathogenesis of Type 1 diabetes mellitus. J Endocrinol Invest. 2008;31(5):406-15. doi: 10.1007/BF03346384. [PubMed: 18560258].
  • 3. Black PH. The inflammatory consequences of psychologic stress: Relationship to insulin resistance, obesity, atherosclerosis and diabetes mellitus, type II. Med Hypotheses. 2006;67(4):879-91. doi: 10.1016/j.mehy.2006.04.008. [PubMed: 16781084].
  • 4. Andersen BL, Farrar WB, Golden-Kreutz D, Kutz LA, MacCallum R, Courtney ME, et al. Stress and immune responses after surgical treatment for regional breast cancer. J Natl Cancer Inst. 1998;90(1):30-6. doi: 10.1093/jnci/90.1.30. [PubMed: 9428780]. [PubMed Central: PMC2743254].
  • 5. Cohen S, Janicki-Deverts D, Miller GE. Psychological stress and disease. JAMA. 2007;298(14):1685-7. doi: 10.1001/jama.298.14.1685. [PubMed: 17925521].
  • 6. Shi Y, Hu FB. The global implications of diabetes and cancer. Lancet. 2014;383(9933):1947-8. doi: 10.1016/S0140-6736(14)60886-2. [PubMed: 24910221].
  • 7. Crump C, Sundquist J, Winkleby MA, Sundquist K. Stress resilience and subsequent risk of type 2 diabetes in 1.5 million young men. Diabetologia. 2016;59(4):728-33. doi: 10.1007/s00125-015-3846-7. [PubMed: 26758065]. [PubMed Central: PMC4779396].
  • 8. Lebovitz HE. Postprandial hyperglycaemic state: Importance and consequences. Diabetes Res Clin Pract. 1998;40 Suppl:S27-8. [PubMed: 9740499].
  • 9. Sepa A, Wahlberg J, Vaarala O, Frodi A, Ludvigsson J. Psychological stress may induce diabetes-related autoimmunity in infancy. Diabetes Care. 2005;28(2):290-5. doi: 10.2337/diacare.28.2.290. [PubMed: 15677781].
  • 10. Petticrew MP, Lee K. The "father of stress" meets "big tobacco": Hans Selye and the tobacco industry. Am J Public Health. 2011;101(3):411-8. doi: 10.2105/AJPH.2009.177634. [PubMed: 20466961]. [PubMed Central: PMC3036703].
  • 11. Szabo S, Tache Y, Somogyi A. The legacy of Hans Selye and the origins of stress research: A retrospective 75 years after his landmark brief "letter" to the editor# of nature. Stress. 2012;15(5):472-8. doi: 10.3109/10253890.2012.710919. [PubMed: 22845714].
  • 12. Nargund VH. Effects of psychological stress on male fertility. Nat Rev Urol. 2015;12(7):373-82. doi: 10.1038/nrurol.2015.112. [PubMed: 26057063].
  • 13. Maass A, Lohaus A, Wolf OT. Media and stress in adolescent boys in Germany: Psychophysiological effects of violent and nonviolent television programs and video games. J Children Media. 2010;4(1):18-38. doi: 10.1080/17482790903407259.
  • 14. Afrisham R, Aberomand M, SoliemaniFar O, Kooti W, Ashtary-Larky D, Alamiri F, et al. Levels of salivary immunoglobulin A under psychological stress and its relationship with rumination and five personality traits in medical students. Eur J Psy. 2016;30(1):41-53.
  • 15. Afrisham R, Sadegh-Nejadi S, SoliemaniFar O, Kooti W, Ashtary-Larky D, Alamiri F, et al. Salivary testosterone levels under psychological stress and its relationship with rumination and five personality traits in medical students. Psychiatry Investig. 2016;13(6):637-43. doi: 10.4306/pi.2016.13.6.637. [PubMed: 27909455]. [PubMed Central: PMC5128352].
  • 16. Afrisham R, Sadegh-Nejadi S, SoliemaniFar O, Abromand M, Kooti W, Najjar Asl S, et al. [Evaluating the salivary alpha-amylase level under psychological stress and its relationship with rumination and the five personality traits]. J Mazandaran Univ Med Sci. 2015;25(126):22-33. Persian.
  • 17. Baum A, Posluszny DM. Health psychology: Mapping biobehavioral contributions to health and illness. Annu Rev Psychol. 1999;50:137-63. doi: 10.1146/annurev.psych.50.1.137. [PubMed: 10074676].
  • 18. Sadegh-Nejadi S, Afrisham R, Soliemanifar O, Kooti W, Aberomand M, Najjar-Asl S, et al. Alteration of the level of salivary cortisol under psychological stress and its relationship with rumination and personality traits. J Gorgan Univ Med Sci. 2017;19(1).
  • 19. Vogelzangs N, Kritchevsky SB, Beekman AT, Newman AB, Satterfield S, Simonsick EM, et al. Depressive symptoms and change in abdominal obesity in older persons. Arch Gen Psychiatry. 2008;65(12):1386-93. doi: 10.1001/archpsyc.65.12.1386. [PubMed: 19047525]. [PubMed Central: PMC3285453].
  • 20. Green PG, Janig W, Levine JD. Negative feedback neuroendocrine control of inflammatory response in the rat is dependent on the sympathetic postganglionic neuron. J Neurosci. 1997;17(9):3234-8. doi: 10.1523/JNEUROSCI.17-09-03234.1997. [PubMed: 9157197].
  • 21. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, et al. Diagnosis and complications of Cushing's syndrome: A consensus statement. J Clin Endocrinol Metab. 2003;88(12):5593-602. doi: 10.1210/jc.2003-030871. [PubMed: 14671138].
  • 22. Pliquett RU, Fasshauer M, Bluher M, Paschke R. Neurohumoral stimulation in type-2-diabetes as an emerging disease concept. Cardiovasc Diabetol. 2004;3:4. doi: 10.1186/1475-2840-3-4. [PubMed: 15028121]. [PubMed Central: PMC406517].
  • 23. Mattacks CA, Pond CM. Interactions of noradrenalin and tumour necrosis factor alpha, interleukin 4 and interleukin 6 in the control of lipolysis from adipocytes around lymph nodes. Cytokine. 1999;11(5):334-46. doi: 10.1006/cyto.1998.0442. [PubMed: 10328873].
  • 24. Uchida Y, Takeshita K, Yamamoto K, Kikuchi R, Nakayama T, Nomura M, et al. Stress augments insulin resistance and prothrombotic state: Role of visceral adipose-derived monocyte chemoattractant protein-1. Diabetes. 2012;61(6):1552-61. doi: 10.2337/db11-0828. [PubMed: 22396205]. [PubMed Central: PMC3357288].
  • 25. Shaw DI, Hall WL, Williams CM. Metabolic syndrome: What is it and what are the implications? Proc Nutr Soc. 2005;64(3):349-57. doi: 10.1079/PNS2005442. [PubMed: 16048668].
  • 26. Barter PJ, Nicholls S, Rye KA, Anantharamaiah GM, Navab M, Fogelman AM. Antiinflammatory properties of HDL. Circ Res. 2004;95(8):764-72. doi: 10.1161/01.RES.0000146094.59640.13. [PubMed: 15486323].
  • 27. Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest. 2002;32 Suppl 3:14-23. doi: 10.1046/j.1365-2362.32.s3.3.x. [PubMed: 12028371].
  • 28. Groeschel M, Braam B. Connecting chronic and recurrent stress to vascular dysfunction: No relaxed role for the renin-angiotensin system. Am J Physiol Renal Physiol. 2011;300(1):F1-10. doi: 10.1152/ajprenal.00208.2010. [PubMed: 20980410].
  • 29. Prasad A, Quyyumi AA. Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome. Circulation. 2004;110(11):1507-12. doi: 10.1161/01.CIR.0000141736.76561.78. [PubMed: 15364819].
  • 30. Hayashi M, Takeshita K, Uchida Y, Yamamoto K, Kikuchi R, Nakayama T, et al. Angiotensin II receptor blocker ameliorates stress-induced adipose tissue inflammation and insulin resistance. PLoS One. 2014;9(12). e116163. doi: 10.1371/journal.pone.0116163. [PubMed: 25551221]. [PubMed Central: PMC4281136].
  • 31. Kalupahana NS, Moustaid-Moussa N. The renin-angiotensin system: A link between obesity, inflammation and insulin resistance. Obes Rev. 2012;13(2):136-49. doi: 10.1111/j.1467-789X.2011.00942.x. [PubMed: 22034852].
  • 32. Neutel JM. Effect of the renin-angiotensin system on the vessel wall: Using ACE inhibition to improve endothelial function. J Hum Hypertens. 2004;18(9):599-606. doi: 10.1038/sj.jhh.1001714. [PubMed: 15190263].
  • 33. Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: A network meta-analysis. Lancet. 2007;369(9557):201-7. doi: 10.1016/S0140-6736(07)60108-1. [PubMed: 17240286].
  • 34. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27(3):813-23. doi: 10.2337/diacare.27.3.813. [PubMed: 14988310].
  • 35. Moberg E, Kollind M, Lins PE, Adamson U. Acute mental stress impairs insulin sensitivity in IDDM patients. Diabetologia. 1994;37(3):247-51. doi: 10.1007/BF00398050. [PubMed: 8174837].
  • 36. Nowotny B, Cavka M, Herder C, Loffler H, Poschen U, Joksimovic L, et al. Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder. Horm Metab Res. 2010;42(10):746-53. doi: 10.1055/s-0030-1261924. [PubMed: 20665427].
  • 37. Zhao WQ, Townsend M. Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim Biophys Acta. 2009;1792(5):482-96. doi: 10.1016/j.bbadis.2008.10.014. [PubMed: 19026743].
  • 38. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98-107. doi: 10.1038/nri2925. [PubMed: 21233852].
  • 39. Sood AK, Bhatty R, Kamat AA, Landen CN, Han L, Thaker PH, et al. Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res. 2006;12(2):369-75. doi: 10.1158/1078-0432.CCR-05-1698. [PubMed: 16428474]. [PubMed Central: PMC3141061].
  • 40. Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, McDonald PG, et al. The influence of bio-behavioural factors on tumour biology: Pathways and mechanisms. Nat Rev Cancer. 2006;6(3):240-8. doi: 10.1038/nrc1820. [PubMed: 16498446]. [PubMed Central: PMC3146042].
  • 41. Jin Shin K, Jin Lee Y, Ryoul Yang Y, Park S, Suh PG, Yung Follo M, et al. Molecular mechanisms underlying psychological stress and cancer. Current Pharmaceutical Design. 2016;22(16):2389-402. doi: 10.2174/1381612822666160226144025.
  • 42. Eng JW, Kokolus KM, Reed CB, Hylander BL, Ma WW, Repasky EA. A nervous tumor microenvironment: The impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response. Cancer Immunol Immunother. 2014;63(11):1115-28. doi: 10.1007/s00262-014-1617-9. [PubMed: 25307152]. [PubMed Central: PMC4325998].
  • 43. Piascik MT, Perez DM. Alpha1-adrenergic receptors: New insights and directions. J Pharmacol Exp Ther. 2001;298(2):403-10. [PubMed: 11454900].
  • 44. Wu D, Katz A, Lee CH, Simon MI. Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family. J Biol Chem. 1992;267(36):25798-802. [PubMed: 1334487].
  • 45. Qin K, Sethi PR, Lambert NA. Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins. FASEB J. 2008;22(8):2920-7. doi: 10.1096/fj.08-105775. [PubMed: 18434433]. [PubMed Central: PMC2493464].
  • 46. Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S. G-protein-coupled receptor genes as protooncogenes: Constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc Natl Acad Sci U S A. 1991;88(24):11354-8. doi: 10.1073/pnas.88.24.11354. [PubMed: 1662393]. [PubMed Central: PMC53133].
  • 47. Okazaki M, Hu ZW, Fujinaga M, Hoffman BB. Alpha 1 adrenergic receptor-induced c-fos gene expression in rat aorta and cultured vascular smooth muscle cells. J Clin Invest. 1994;94(1):210-8. doi: 10.1172/JCI117309. [PubMed: 8040263]. [PubMed Central: PMC296299].
  • 48. Vazquez SM, Mladovan AG, Perez C, Bruzzone A, Baldi A, Luthy IA. Human breast cell lines exhibit functional alpha2-adrenoceptors. Cancer Chemother Pharmacol. 2006;58(1):50-61. doi: 10.1007/s00280-005-0130-4. [PubMed: 16292538].
  • 49. Bruzzone A, Pinero CP, Castillo LF, Sarappa MG, Rojas P, Lanari C, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008;155(4):494-504. doi: 10.1038/bjp.2008.278. [PubMed: 18604234]. [PubMed Central: PMC2579667].
  • 50. Jiang Q, Ding S, Wu J, Liu X, Wu Z. Norepinephrine stimulates mobilization of endothelial progenitor cells after limb ischemia. PLoS One. 2014;9(7). e101774. doi: 10.1371/journal.pone.0101774. [PubMed: 25007164]. [PubMed Central: PMC4090158].
  • 51. Huang JL, Zhang YL, Wang CC, Zhou JR, Ma Q, Wang X, et al. Enhanced phosphorylation of MAPKs by NE promotes TNF-alpha production by macrophage through alpha adrenergic receptor. Inflammation. 2012;35(2):527-34. doi: 10.1007/s10753-011-9342-4. [PubMed: 21590324].
  • 52. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005;121(3):335-48. doi: 10.1016/j.cell.2005.02.034. [PubMed: 15882617].
  • 53. Bruzzone A, Pinero CP, Rojas P, Romanato M, Gass H, Lanari C, et al. alpha(2)-Adrenoceptors enhance cell proliferation and mammary tumor growth acting through both the stroma and the tumor cells. Curr Cancer Drug Targets. 2011;11(6):763-74. doi: 10.2174/156800911796191051. [PubMed: 21599632].
  • 54. Ara T, Declerck YA. Interleukin-6 in bone metastasis and cancer progression. Eur J Cancer. 2010;46(7):1223-31. doi: 10.1016/j.ejca.2010.02.026. [PubMed: 20335016]. [PubMed Central: PMC2917917].
  • 55. Valles SL, Benlloch M, Rodriguez ML, Mena S, Pellicer JA, Asensi M, et al. Stress hormones promote growth of B16-F10 melanoma metastases: An interleukin 6- and glutathione-dependent mechanism. J Transl Med. 2013;11:72. doi: 10.1186/1479-5876-11-72. [PubMed: 23517603]. [PubMed Central: PMC3608962].
  • 56. Nilsson MB, Armaiz-Pena G, Takahashi R, Lin YG, Trevino J, Li Y, et al. Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism. J Biol Chem. 2007;282(41):29919-26. doi: 10.1074/jbc.M611539200. [PubMed: 17716980].
  • 57. Armaiz-Pena GN, Allen JK, Cruz A, Stone RL, Nick AM, Lin YG, et al. Src activation by beta-adrenoreceptors is a key switch for tumour metastasis. Nat Commun. 2013;4:1403. doi: 10.1038/ncomms2413. [PubMed: 23360994]. [PubMed Central: PMC3561638].
  • 58. Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery. 2004;135(5):555-62. doi: 10.1016/j.surg.2003.10.017. [PubMed: 15118593].
  • 59. Sood AK, Armaiz-Pena GN, Halder J, Nick AM, Stone RL, Hu W, et al. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest. 2010;120(5):1515-23. doi: 10.1172/JCI40802. [PubMed: 20389021]. [PubMed Central: PMC2860925].
  • 60. Tilly JL. Commuting the death sentence: How oocytes strive to survive. Nat Rev Mol Cell Biol. 2001;2(11):838-48. doi: 10.1038/35099086. [PubMed: 11715050].
  • 61. Chen H, Liu D, Yang Z, Sun L, Deng Q, Yang S, et al. Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk. Endocr Relat Cancer. 2014;21(5):783-95. doi: 10.1530/ERC-14-0236. [PubMed: 25179535].
  • 62. Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, et al. A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1. Nature. 2011;477(7364):349-53. doi: 10.1038/nature10368. [PubMed: 21857681]. [PubMed Central: PMC3628753].
  • 63. Masur K, Niggemann B, Zanker KS, Entschladen F. Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res. 2001;61(7):2866-9. [PubMed: 11306460].
  • 64. Pan WK, Li P, Guo ZT, Huang Q, Gao Y. Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/VEGF pathway. Pediatr Blood Cancer. 2015;62(8):1414-20. doi: 10.1002/pbc.25453. [PubMed: 25728347].
  • 65. Nagaraja AS, Dorniak PL, Sadaoui NC, Kang Y, Lin T, Armaiz-Pena G, et al. Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. Oncogene. 2016;35(18):2390-7. doi: 10.1038/onc.2015.302. [PubMed: 26257064]. [PubMed Central: PMC4749473].
  • 66. Shi M, Liu D, Duan H, Qian L, Wang L, Niu L, et al. The beta2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells. Breast Cancer Res Treat. 2011;125(2):351-62. doi: 10.1007/s10549-010-0822-2. [PubMed: 20237834].
  • 67. Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009;9(5):361-71. doi: 10.1038/nrc2628. [PubMed: 19343034].
  • 68. Wu W, Pew T, Zou M, Pang D, Conzen SD. Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J Biol Chem. 2005;280(6):4117-24. doi: 10.1074/jbc.M411200200. [PubMed: 15590693].
  • 69. Peters MA, Walenkamp AM, Kema IP, Meijer C, de Vries EG, Oosting SF. Dopamine and serotonin regulate tumor behavior by affecting angiogenesis. Drug Resist Updat. 2014;17(4-6):96-104. doi: 10.1016/j.drup.2014.09.001. [PubMed: 25269824].
  • 70. Basu S, Nagy JA, Pal S, Vasile E, Eckelhoefer IA, Bliss VS, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001;7(5):569-74. doi: 10.1038/87895. [PubMed: 11329058].
  • 71. Hoeppner LH, Wang Y, Sharma A, Javeed N, Van Keulen VP, Wang E, et al. Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells. Mol Oncol. 2015;9(1):270-81. doi: 10.1016/j.molonc.2014.08.008. [PubMed: 25226814]. [PubMed Central: PMC4277897].

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