Effect of garlic on serum adiponectin and interleukin levels in women with metabolic syndrome

AUTHORS

Faranak Sharifi 1 , * , Abdolkarim Sheikhi 2 , Mahnaz Behdad 2 , Nouraddin Mousavinasab 2

1 Metabolic Diseases Research Center, Valieasr Hospital, Zanjan University of Medical Sciences, [email protected], IR Iran

2 Metabolic Diseases Research Center, Valieasr Hospital, Zanjan University of Medical Sciences, IR Iran

How to Cite: Sharifi F, Sheikhi A, Behdad M, Mousavinasab N. Effect of garlic on serum adiponectin and interleukin levels in women with metabolic syndrome, Int J Endocrinol Metab. Online ahead of Print ; 8(2):68-73.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 8 (2); 68-73
Article Type: Original Article
Received: July 5, 2010
Accepted: December 26, 2010

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Abstract

Background: Metabolic syndrome is considered to be an inflammatory situation with highly production of adipokines. Garlic and its products are known to induce anti-inflammatory effects. However, no data are available on the anti- inflammatory effects of garlic in subjects with metabolic syndrome.
Objectives: This study was designed to investigate the effects of a chemically wellcharacterized garlic preparation on biomarkers for inflammation, and lipid metabolism in subjects with metabolic syndrome.
Patients and Methods: This study was a double-blind, randomized, placebo-controlled trial in 40 adult women, aged > 18 year, who were diagnosed to have metabolic syndrome based on ATPIII criteria and 10 normal women. The cases were randomly assigned to 2 parallel treatment groups: garlic tablets (1.8 g/d), or placebo. Serum adiponectin, interleukin 6, TNF α and lipid profiles were measured at baseline and after 6 weeks of treatment and anthropometric measurements were recorded.
Results: Compared to the placebo group, garlic treatment resulted in significantly lower weight and waist circumference in women with metabolic syndrome. No effect on weight was detected in normal subjects with garlic. None of the inflammatory biomarkers and plasma lipid levels showed significant differences between the garlic-treated and the placebo groups.
Conclusions: This study confirms that garlic has no effect on major plasma lipoproteins and furthermore has no impact on inflammatory biomarkers in women with metabolic syndrome.

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Please cite this paper as:
Sharifi F, Sheikhi AK, Behdad M, Mousavinasab N. Effect of garlic on serum adiponectin and interleukin levels in women with metabolic syndrome. Int J Endocrinol Metab. 2010;8(2):68-73.

Keywords

Garlic Metabolic syndrome Lipids TNF alpha Interleukin 6 Adiponectin

© 0, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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