Cite Score:
1.77
ELSEVIER SCOPUS

Diminished Response of Isolated Aorta Chronic Physical and Psychological Stress and its Reversibility in Rats

AUTHORS

Asghar Ghasemi 1 , Farzaneh Faraji 1 , Faraz Valaee 1 , Katayon Sedaghat 1 , Maedeh Arabian 1 , Saleh Zahediasl 2 , *

AUTHORS INFORMATION

1 Endocrine Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences, IR Iran

2 Endocrine Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences, zahedi@endocrine.ac.ir, IR Iran

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 10 (1); 423-428
Article Type: Original Article
Received: November 5, 2011
Accepted: December 22, 2011
Crossmark

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: The role of stress has been elucidated in cardiovascular disorders. The aim of this study was to determine and compare the effects of chronic physical and psychological stress on the contractility of isolated rat aorta and their reversibility.
Materials and Methods: Wister rats were divided into 3 groups: control, physical stress, and psychological stress (n = 12). Animals were kept on 12-h/12-h light/dark cycles at 22 ± 2°C and had free access to food and water. Physical and psychological stress was induced using a communication box for 3 weeks. Physical stress was applied with electrical current (1 mA, 1 Hz, 10 sec/min) 1 hour twice daily. To assess the aortic response, the animals were anesthetized, abdominal aortas were removed, and the contractility response to potassium chloride and phenylephrine was measured with an isometric transducer. To study the reversibility of the effects, separate groups of stressed animals and a control group (n = 12 in each group) were kept for 1 month following the stress period, and the aortic responses were evaluated and compared.
Results: In the stressed group, the aortic responses to potassium chloride and phenylephrine were significantly lower compared with the controls, whereas the corticosterone concentration was higher. Following a 1-month recovery, both values returned to normal.
Conclusions: Chronic physical stress and psychological stress have similar effects on vascular responsiveness, which are reversible; these findings may be clinically important in the treatment of stress-related cardiovascular disorders.


  • Implication for health policy/practice/research/medical education:
    Although the study has been performed in animal model, the findings will shed some more lights on the impacts of two types of stresses on cardiovascular system
  • Please cite this paper as:
    Ghasemi A, Faraji F, Valaee F, Sedaghat K, Arabian M, Zahediasl S. Diminished Response of Isolated Aorta Following Chronic Physical and Psychological Stresses and its Reversibility in Rats. Int J Endocrinal Metab.2012; 10(1): 423-8. DOI: 10.5812/ijem.4062

Copyright © 2012 Kowsar M. P. Co. All rights reserved.


Keywords

Restraint Physical Stress Psychological Aorta Rat

© 0, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: