GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome
International Journal of Endocrinology and Metabolism: 11 (2); 107-16
March 31, 2013
Article Type: Review Article
July 8, 2012
August 17, 2012
J. GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome,
Int J Endocrinol Metab.
Online ahead of Print
The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.
Ovarian Stimulation; Ovarian Hyperstimulation Syndrome; Prevention; GnRH Agonist; GnRH Antagonist
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