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GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

AUTHORS

Pilar Alama 1 , Jose Bellver 2 , Carmen Vidal 1 , Juan Giles 1 , *

AUTHORS INFORMATION

1 Department of Reproduction, IVI-Valencia, Plaza de la Policia Local, Valencia, Spain

2 Department of Paediatrics, Obstetrics and Gynaecology, Faculty of Medicine. University of Valencia, Valencia, Spain

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 11 (2); 107-16
Published Online: March 31, 2013
Article Type: Review Article
Received: July 8, 2012
Accepted: August 17, 2012
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Abstract

Abstract: The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.

Keywords

Ovarian Stimulation Ovarian Hyperstimulation Syndrome Prevention GnRH Agonist GnRH Antagonist

© 2013, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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