International Journal of Endocrinology and Metabolism

Published by: Kowsar

Correlation of C1q/TNF-Related Protein-3 with Cardiac Autonomic Tone and Metabolic Parameters in Obesity

Neha Bindlish Jain 1 , Asha Yadav 1 , * , Nilima Shankar 1 and Rafat Ahmed 2
Authors Information
1 Department of Physiology, University College of Medical Sciences, Delhi, India
2 Department of Biochemistry, University College of Medical Sciences, Delhi, India
Article information
  • International Journal of Endocrinology and Metabolism: April 30, 2019, 17 (2); e74250
  • Published Online: April 17, 2019
  • Article Type: Research Article
  • Received: May 4, 2018
  • Revised: January 29, 2019
  • Accepted: March 12, 2019
  • DOI: 10.5812/ijem.74250

To Cite: Jain N B, Yadav A, Shankar N, Ahmed R. Correlation of C1q/TNF-Related Protein-3 with Cardiac Autonomic Tone and Metabolic Parameters in Obesity, Int J Endocrinol Metab. 2019 ; 17(2):e74250. doi: 10.5812/ijem.74250.

Copyright © 2019, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Schaffler A, Scholmerich J, Salzberger B. Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs. Trends Immunol. 2007;28(9):393-9. doi: 10.1016/ [PubMed: 17681884].
  • 2. Schmid A, Kopp A, Hanses F, Karrasch T, Schaffler A. C1q/TNF-related protein-3 (CTRP-3) attenuates lipopolysaccharide (LPS)-induced systemic inflammation and adipose tissue Erk-1/-2 phosphorylation in mice in vivo. Biochem Biophys Res Commun. 2014;452(1):8-13. doi: 10.1016/j.bbrc.2014.06.054. [PubMed: 24996172].
  • 3. Wolf RM, Steele KE, Peterson LA, Magnuson TH, Schweitzer MA, Wong GW. Lower circulating C1q/TNF-related protein-3 (CTRP3) levels are associated with obesity: A cross-sectional study. PLoS One. 2015;10(7). doi: 10.1371/journal.pone.0133955.
  • 4. Yi W, Sun Y, Yuan Y, Lau WB, Zheng Q, Wang X, et al. C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart. Circulation. 2012;125(25):3159-69. doi: 10.1161/CIRCULATIONAHA.112.099937. [PubMed: 22653084]. [PubMed Central: PMC3391311].
  • 5. Seldin MM, Tan SY, Wong GW. Metabolic function of the CTRP family of hormones. Rev Endocr Metab Disord. 2014;15(2):111-23. doi: 10.1007/s11154-013-9255-7. [PubMed: 23963681]. [PubMed Central: PMC3931758].
  • 6. Schaffler A, Buechler C. CTRP family: Linking immunity to metabolism. Trends Endocrinol Metab. 2012;23(4):194-204. doi: 10.1016/j.tem.2011.12.003. [PubMed: 22261190].
  • 7. Smith MM, Minson CT. Obesity and adipokines: Effects on sympathetic overactivity. J Physiol. 2012;590(8):1787-801. doi: 10.1113/jphysiol.2011.221036. [PubMed: 22351630]. [PubMed Central: PMC3573303].
  • 8. Vaz M, Jennings G, Turner A, Cox H, Lambert G, Esler M. Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation. 1997;96(10):3423-9. doi: 10.1161/01.CIR.96.10.3423. [PubMed: 9396437].
  • 9. Hirsch J, Leibel RL, Mackintosh R, Aguirre A. Heart rate variability as a measure of autonomic function during weight change in humans. Am J Physiol. 1991;261(6 Pt 2):R1418-23. doi: 10.1152/ajpregu.1991.261.6.R1418. [PubMed: 1750566].
  • 10. Petretta M, Bonaduce D, de Filippo E, Mureddu GF, Scalfi L, Marciano F, et al. Assessment of cardiac autonomic control by heart period variability in patients with early-onset familial obesity. Eur J Clin Invest. 1995;25(11):826-32. doi: 10.1111/j.1365-2362.1995.tb01691.x. [PubMed: 8582447].
  • 11. Straznicky NE, Eikelis N, Lambert EA, Esler MD. Mediators of sympathetic activation in metabolic syndrome obesity. Curr Hypertens Rep. 2008;10(6):440-7. doi: 10.1007/s11906-008-0083-1. [PubMed: 18959829].
  • 12. Kurajoh M, Koyama H, Kadoya M, Naka M, Miyoshi A, Kanzaki A, et al. Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study. Cardiovasc Diabetol. 2015;14:117. doi: 10.1186/s12933-015-0280-6. [PubMed: 26338087]. [PubMed Central: PMC4560071].
  • 13. Van De Wielle R, Michels N. Longitudinal associations of leptin and adiponectin with heart rate variability in children. Front Physiol. 2017;8:498. doi: 10.3389/fphys.2017.00498. [PubMed: 28747890]. [PubMed Central: PMC5506193].
  • 14. Charles LE, Burchfiel CM, Sarkisian K, Li S, Miller DB, Gu JK, et al. Leptin, adiponectin, and heart rate variability among police officers. Am J Hum Biol. 2015;27(2):184-91. doi: 10.1002/ajhb.22636. [PubMed: 25270126]. [PubMed Central: PMC4699294].
  • 15. Pieterse C, Schutte R, Schutte AE. Autonomic activity and leptin in Africans and whites: The SABPA study. J Hypertens. 2014;32(4):826-33. doi: 10.1097/HJH.0000000000000110. [PubMed: 24509121].
  • 16. Malik M, Bigger JT, Camm AJ, Kleiger RE, Malliani A, Moss AJ, et al. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J. 1996;17(3):354-81. doi: 10.1093/oxfordjournals.eurheartj.a014868. [PubMed: 8737210].
  • 17. Tan BK, Chen J, Hu J, Amar O, Mattu HS, Adya R, et al. Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2013;98(12):E1891-900. doi: 10.1210/jc.2013-2227. [PubMed: 24152681].
  • 18. Yoo HJ, Hwang SY, Hong HC, Choi HY, Yang SJ, Choi DS, et al. Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome. PloS one. 2013;8(2). doi: 10.1371/journal.pone.0055744.
  • 19. Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, et al. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013;36(10):3321-7. doi: 10.2337/dc13-0178. [PubMed: 23780948]. [PubMed Central: PMC3781543].
  • 20. Choi KM, Hwang SY, Hong HC, Yang SJ, Choi HY, Yoo HJ, et al. C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. Diabetes. 2012;61(11):2932-6. doi: 10.2337/db12-0217. [PubMed: 22837306]. [PubMed Central: PMC3478553].
  • 21. Wen CP, David Cheng TY, Tsai SP, Chan HT, Hsu HL, Hsu CC, et al. Are Asians at greater mortality risks for being overweight than Caucasians? Redefining obesity for Asians. Public Health Nutr. 2009;12(4):497-506. doi: 10.1017/S1368980008002802. [PubMed: 18547457].
  • 22. Gayoso-Diz P, Otero-Gonzalez A, Rodriguez-Alvarez MX, Gude F, Garcia F, De Francisco A, et al. Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: Effect of gender and age: EPIRCE cross-sectional study. BMC Endocr Disord. 2013;13:47. doi: 10.1186/1472-6823-13-47. [PubMed: 24131857]. [PubMed Central: PMC4016563].
  • 23. Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, Abrishami M, Juya M, Khodaee G, et al. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease. Med J Islam Repub Iran. 2015;29:240. [PubMed: 26793631]. [PubMed Central: PMC4715400].
  • 24. Chaudhuri R. Autonomic failure. A textbook of clinical disorders of the autonomic nervous system: Edited by Christopher J Mathias and Sir Roger Bannister. Oxford: Oxford University Press; 2002. doi: 10.1136/jnnp.74.4.551.
  • 25. Deng W, Li C, Zhang Y, Zhao J, Yang M, Tian M, et al. Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. Diabetol Metab Syndr. 2015;7:33. doi: 10.1186/s13098-015-0029-0. [PubMed: 25878729]. [PubMed Central: PMC4397726].
  • 26. Wagner RM, Sivagnanam K, Clark WA, Peterson JM. Divergent relationship of circulating CTRP3 levels between obesity and gender: A cross-sectional study. PeerJ. 2016;4. e2573. doi: 10.7717/peerj.2573. [PubMed: 27781167]. [PubMed Central: PMC5075694].
  • 27. Ban B, Bai B, Zhang M, Hu J, Ramanjaneya M, Tan BK, et al. Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: In vivo regulation of cartonectin by glucose. PloS one. 2014;9(11). doi: 10.1371/journal.pone.0112931. [PubMed: 25409499]. [PubMed Central: PMC4237345].
  • 28. Peterson JM, Wei Z, Wong GW. C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem. 2010;285(51):39691-701. doi: 10.1074/jbc.M110.180695. [PubMed: 20952387]. [PubMed Central: PMC3000950].
  • 29. Kwon MR, Cress E, Clark WA, Alamian A, Lu Y, Peterson JM. The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers. PeerJ. 2018;6. e4472. doi: 10.7717/peerj.4472. [PubMed: 29527418]. [PubMed Central: PMC5842766].
  • 30. Sawicka M, Janowska J, Chudek J. Potential beneficial effect of some adipokines positively correlated with the adipose tissue content on the cardiovascular system. Int J Cardiol. 2016;222:581-9. doi: 10.1016/j.ijcard.2016.07.054. [PubMed: 27513655].
  • 31. Li Y, Ozment T, Wright GL, Peterson JM. Identification of putative receptors for the novel adipokine CTRP3 using ligand-receptor capture technology. PLoS One. 2016;11(10). e0164593. doi: 10.1371/journal.pone.0164593. [PubMed: 27727322]. [PubMed Central: PMC5058508].
  • 32. Valensi P, Thi BN, Lormeau B, Paries J, Attali JR. Cardiac autonomic function in obese patients. Int J Obes Relat Metab Disord. 1995;19(2):113-8. [PubMed: 7735337].
  • 33. Li X, Jiang L, Yang M, Wu YW, Sun SX, Sun JZ. CTRP3 modulates the expression and secretion of adipokines in 3T3-L1 adipocytes. Endocr J. 2014;61(12):1153-62. doi: 10.1507/endocrj.EJ14-0161. [PubMed: 25168658].
  • 34. Nishimoto H, Yamamoto A, Furukawa S, Wakisaka S, Maeda T. C1q/TNF-related protein 3 expression and effects on adipocyte differentiation of 3T3-L1 cells. Cell Biol Int. 2017;41(2):197-203. doi: 10.1002/cbin.10674. [PubMed: 27590487].
  • 35. Wong GW, Wang J, Hug C, Tsao TS, Lodish HF. A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A. 2004;101(28):10302-7. doi: 10.1073/pnas.0403760101. [PubMed: 15231994]. [PubMed Central: PMC478567].

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