International Journal of Endocrinology and Metabolism

Published by: Kowsar

Vitamin D Increases Glucose Stimulated Insulin Secretion from Insulin Producing Beta Cells (INS1E)

Mette Eskild Bornstedt 1 , 2 , * , Nina Gjerlaugsen 1 , Milaim Pepaj 1 , May K L Bredahl 1 and Per M Thorsby 1
Authors Information
1 Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
2 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
Article information
  • International Journal of Endocrinology and Metabolism: 17 (1); e74255
  • Published Online: January 7, 2019
  • Article Type: Research Article
  • Received: May 4, 2018
  • Revised: October 25, 2018
  • Accepted: December 11, 2018
  • DOI: 10.5812/ijem.74255

To Cite: Bornstedt M E, Gjerlaugsen N, Pepaj M, Bredahl M K L, Thorsby P M. Vitamin D Increases Glucose Stimulated Insulin Secretion from Insulin Producing Beta Cells (INS1E), Int J Endocrinol Metab. Online ahead of Print ; 17(1):e74255. doi: 10.5812/ijem.74255.

Abstract
Copyright © 2019, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives. Nat Rev Endocrinol. 2011;8(4):228-36. doi: 10.1038/nrendo.2011.183. [PubMed: 22064493].
  • 2. Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care. 1994;17(9):961-9. [PubMed: 7988316].
  • 3. Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA. Metabolic syndrome and development of diabetes mellitus: Application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol. 2002;156(11):1070-7. [PubMed: 12446265].
  • 4. Thorsby PM. Studies of candidate genes in overweight and diabetes mellitus [dissertation]. Oslo: Faculty of Medicine, University of Oslo; 2013.
  • 5. Wang Y, He D, Ni C, Zhou H, Wu S, Xue Z, et al. Vitamin D induces autophagy of pancreatic beta-cells and enhances insulin secretion. Mol Med Rep. 2016;14(3):2644-50. doi: 10.3892/mmr.2016.5531. [PubMed: 27430408].
  • 6. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414(6865):782-7. doi: 10.1038/414782a. [PubMed: 11742409].
  • 7. Langenberg C, Lotta LA. Genomic insights into the causes of type 2 diabetes. Lancet. 2018;391(10138):2463-74. doi: 10.1016/S0140-6736(18)31132-2. [PubMed: 29916387].
  • 8. Lawlor N, Khetan S, Ucar D, Stitzel ML. Genomics of Islet (Dys)function and Type 2 Diabetes. Trends Genet. 2017;33(4):244-55. doi: 10.1016/j.tig.2017.01.010. [PubMed: 28245910]. [PubMed Central: PMC5458785].
  • 9. Petrie JR, Pearson ER, Sutherland C. Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology. Biochem Pharmacol. 2011;81(4):471-7. doi: 10.1016/j.bcp.2010.11.010. [PubMed: 21111713].
  • 10. Neelankal John A, Iqbal Z, Colley S, Morahan G, Makishima M, Jiang FX. Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic beta cells under hyperglycaemic stress. Diabetes Metab. 2018;44(3):269-80. doi: 10.1016/j.diabet.2017.07.006. [PubMed: 28918929].
  • 11. Umar M, Sastry KS, Chouchane AI. Role of vitamin D beyond the skeletal function: A review of the molecular and clinical studies. Int J Mol Sci. 2018;19(6). doi: 10.3390/ijms19061618. [PubMed: 29849001]. [PubMed Central: PMC6032242].
  • 12. Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol. 2004;89-90(1-5):121-5. doi: 10.1016/j.jsbmb.2004.03.115. [PubMed: 15225758].
  • 13. Adams JS, Hewison M. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Arch Biochem Biophys. 2012;523(1):95-102. doi: 10.1016/j.abb.2012.02.016. [PubMed: 22446158]. [PubMed Central: PMC3361592].
  • 14. Maestro B, Campion J, Davila N, Calle C. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 2000;47(4):383-91. [PubMed: 11075718].
  • 15. Bikle DD. Extraskeletal actions of vitamin D. Ann N Y Acad Sci. 2016;1376(1):29-52. doi: 10.1111/nyas.13219. [PubMed: 27649525]. [PubMed Central: PMC5031366].
  • 16. Gysemans CA, Cardozo AK, Callewaert H, Giulietti A, Hulshagen L, Bouillon R, et al. 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: Implications for prevention of diabetes in nonobese diabetic mice. Endocrinology. 2005;146(4):1956-64. doi: 10.1210/en.2004-1322. [PubMed: 15637289].
  • 17. Wolden-Kirk H, Rondas D, Bugliani M, Korf H, Van Lommel L, Brusgaard K, et al. Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans. Endocrinology. 2014;155(3):736-47. doi: 10.1210/en.2013-1409. [PubMed: 24424042].
  • 18. Wolden-Kirk H, Overbergh L, Gysemans C, Brusgaard K, Naamane N, Van Lommel L, et al. Unraveling the effects of 1,25OH2D3 on global gene expression in pancreatic islets. J Steroid Biochem Mol Biol. 2013;136:68-79. doi: 10.1016/j.jsbmb.2012.10.017. [PubMed: 23137852].
  • 19. Jeddi S, Syedmoradi L, Bagheripour F, Ghasemi A. The effects of vitamin d on insulin release from isolated islets of rats. Int J Endocrinol Metab. 2015;13(1). e20620. doi: 10.5812/ijem.20620. [PubMed: 25745495]. [PubMed Central: PMC4338668].
  • 20. Pepaj M, Bredahl MK, Gjerlaugsen N, Bornstedt ME, Thorsby PM. Discovery of novel vitamin D-regulated proteins in INS-1 cells: A proteomic approach. Diabetes Metab Res Rev. 2015;31(5):481-91. doi: 10.1002/dmrr.2629. [PubMed: 25449168].
  • 21. Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P. Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology. 2004;145(2):667-78. doi: 10.1210/en.2003-1099. [PubMed: 14592952].
  • 22. d'Emden MC, Dunlop M, Larkins RG, Wark JD. The in vitro effect of 1 alpha,25-dihydroxyvitamin D3 on insulin production by neonatal rat islets. Biochem Biophys Res Commun. 1989;164(1):413-8. [PubMed: 2679556].
  • 23. Billaudel BJ, Faure AG, Sutter BC. Effect of 1,25 dihydroxyvitamin D3 on isolated islets from vitamin D3-deprived rats. Am J Physiol. 1990;258(4 Pt 1):E643-8. doi: 10.1152/ajpendo.1990.258.4.E643. [PubMed: 2185647].
  • 24. Tanaka Y, Seino Y, Ishida M, Yamaoka K, Yabuuchi H, Ishida H, et al. Effect of vitamin D3 on the pancreatic secretion of insulin and somatostatin. Acta Endocrinol (Copenh). 1984;105(4):528-33. [PubMed: 6144227].
  • 25. Bourlon PM, Billaudel B, Faure-Dussert A. Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol. 1999;160(1):87-95. [PubMed: 9854180].
  • 26. Bourlon PM, Faure-Dussert A, Billaudel B. Modulatory role of 1,25 dihydroxyvitamin D3 on pancreatic islet insulin release via the cyclic AMP pathway in the rat. Br J Pharmacol. 1997;121(4):751-8. doi: 10.1038/sj.bjp.0701204. [PubMed: 9208144]. [PubMed Central: PMC1564753].
  • 27. Neelankal John A, Jiang FX. An overview of type 2 diabetes and importance of vitamin D3-vitamin D receptor interaction in pancreatic beta-cells. J Diabetes Complications. 2018;32(4):429-43. doi: 10.1016/j.jdiacomp.2017.12.002. [PubMed: 29422234].
  • 28. Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology. 1992;130(1):167-78. doi: 10.1210/endo.130.1.1370150. [PubMed: 1370150].
  • 29. Rutter GA, Hodson DJ. Minireview: Intraislet regulation of insulin secretion in humans. Mol Endocrinol. 2013;27(12):1984-95. doi: 10.1210/me.2013-1278. [PubMed: 24243488]. [PubMed Central: PMC5426601].
  • 30. Gamady A, Koren R, Ron D, Liberman UA, Ravid A. Vitamin D enhances mitogenesis mediated by keratinocyte growth factor receptor in keratinocytes. J Cell Biochem. 2003;89(3):440-9. doi: 10.1002/jcb.10508. [PubMed: 12761878].
  • 31. Sergeev IN. Vitamin D-mediated apoptosis in cancer and obesity. Horm Mol Biol Clin Investig. 2014;20(2):43-9. doi: 10.1515/hmbci-2014-0035. [PubMed: 25460294].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments