Tetralogy of Fallot Associated With Invasive Adrenocortical Tumor in an Adult Woman

AUTHORS

Efren Martinez-Quintana 1 , * , Fayna Rodriguez-Gonzalez 2 , Maria Pino Pino Alberiche-Ruano 3 , Maria Soledad Soledad Martinez-Martin 4

1 Cardiology Service. Insular-Materno Infantil University Hospital, efrenmartinezquintana@yahoo.es, Spain

2 Ophthalmology Service. Dr. Negrn University Hospital, Spain

3 Endocrinology Service. Insular-Materno Infantil University Hospital, Spain

4 Anatomopathology Service. Insular-Materno Infantil University Hospital, Spain

How to Cite: Martinez-Quintana E, Rodriguez-Gonzalez F, Alberiche-Ruano M P, Martinez-Martin M S. Tetralogy of Fallot Associated With Invasive Adrenocortical Tumor in an Adult Woman, Int J Endocrinol Metab. Online ahead of Print ; 10(2):503-505. doi: 10.5812/ijem.3769.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 10 (2); 503-505
Published Online: April 20, 2012
Article Type: Case Report
Received: December 10, 2011
Accepted: February 4, 2012
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Abstract

Migration of cardiac neural crest cells into the pharyngeal arches and the pharyngeal and splanchnic mesoderm contributes to the development of the cardiac outflow tract. The adrenal cortex is derived from the splanchnic mesoderm. Neuroblastoma is more prevalent in patients with congenital heart disease than in the general population, because both originate from embryonal neural crest-derived cells. Similarly, and in light of recent embryological findings, abnormal development or migration of splanchnic mesoderm, possibly due to an underlying genetic defect, could contribute to the association of adrenocortical carcinoma and tetralogy of Fallot. We present the case of a cardiologically asymptomatic 49-year-old woman with total correction of tetralogy of Fallot in the first year of life.

Keywords

Tetralogy of Fallot Adernal Cortex Neoplasms Woman

© 2012, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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