Assessment of Cognitive Function, Mood, and Quality of Life in Hypopituitary Patients After Pituitary Adenomectomy With or Without Radiotherapy

AUTHORS

Carolina Petry 1 , Maria Carolina Rios 1 , Carolina Garcia Soares Leaes 1 , Julia Fernanda Semmelmman Pereira-Lima 1 , Miriam da Costa Oliveira 2 , *

1 Center for Neuroendocrinology, Santa Casa Hospital Complex, University of Health Sciences of Port Alegre (UFCSPA), Brazil

2 Center for Neuroendocrinology, Santa Casa Hospital Complex, University of Health Sciences of Port Alegre (UFCSPA), [email protected], Brazil

How to Cite: Petry C, Rios M, Leaes C, Pereira-Lima J, Oliveira M. Assessment of Cognitive Function, Mood, and Quality of Life in Hypopituitary Patients After Pituitary Adenomectomy With or Without Radiotherapy, Int J Endocrinol Metab. Online ahead of Print ; 9(2):306-310. doi: 10.5812/kowsar.1726913X.2597.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 9 (2); 306-310
Article Type: Original Article
Received: January 12, 2011
Accepted: March 22, 2011
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Abstract

Background: Pituitary diseases are often associated with changes in quality of life. Hypopituitarism and radiotherapy may negatively affect quality of life, causing depression and anxiety and resulting in cognitive disorders.
Objectives: To comparatively evaluate cognitive function and quality of life in patients with pituitary adenomas who developed hypopituitarism after surgery, with or without radiotherapy.
Patients and Methods: Out of a total of 36 patients enrolled in the study, 25 (70%) received conformal radiotherapy as an adjuvant treatment. The mean age was 47 ± 13 years in the radiotherapy group and 48 ± 12 years in the non-radiotherapy group. All the patients had hypopituitarism and had undergone hormone replacement therapy, with the exception of the growth hormone, for the entire axes. Tests to assess cognitive function, anxiety, depression, and quality of life were performed on an outpatient basis.
Results: There were no differences between the groups, with respect to gender, educational level, and presence of deficit in the adrenal, gonadal, somatotropic, or thyroid axis. Mean time since surgery and that since radiotherapy was 10 ± 5 years and 10 ± 6 years, respectively. All the patients had some degree of anxiety and depression on the basis of their Beck Anxiety and Depression Inventory scores. There was a trend toward greater depression severity in the group undergoing radiotherapy (p = 0.058). With respect to the health-related quality of life, a significant difference was detected in social relationships, with lower scores observed in the radiotherapy group.
Conclusions: Irradiated hypopituitary patients showed impairment in the social relationship aspect of their quality of life and greater depression severity.


 

  • Implication for health policy/practice/research/medical education:
    There is a lack of clinical studies and reviews specifically evaluating the role of surgical hypopituitarism and radiotherapy in the HQOL, mood, and cognitive function of patients.
  • Please cite this paper as:
    Petry C; Rios MC; Leaes CGS; Pereira-Lima JFS; Oliveira Mdc, Assessment of Cognitive Function, Mood, and Quality of Life in Hypopituitary Patients After Pituitary Adenomectomy With or Without Radiotherapy. Int J Endocriol Metab.2011;9(2):306-10.
  • DOI: 10.5812/kowsar.1726913X.2597

Copyright© 2011 Kowsar M.P.Co. All rights reserved.


Keywords

Pituitary Gland Hypophysectomy Hypopituitarism Radiotherapy

© 0, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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