Adipose Tissue Characteristics Related to Weight Z-Score in Childhood

AUTHORS

Juan Jesus Haro-Mora 2 , * , Eva Garcia-Escobar 2 , Nuria Porras 2 , Dolores Alcazar 3 , Joaquin Gaztambide 3 , Antonio Ruiz-Orpez 3 , Sara Garcia-Serrano 2 , Juan M. Gomez-Zumaquero 2 , Eduardo Garcia-Fuentes 4 , Juan P Lopez-Siguero 5 , Federico Soriguer 2 , Gemma Rojo-Martinez 2

2 Health Institute Carlos III, CIBERDEM, CB07/08/0019, Malaga, Spain

3 Maternal and Child Hospital of Malaga, Pediatric Surgery Department, Malaga, Spain

4 Health Institute Carlos III, CIBEROBN, CB06/03/0060 Malaga, Spain

5 Maternal and Child Hospital of Malaga, Pediatric endocrinology Department, Spain

How to Cite: Haro-Mora J J, Garcia-Escobar E, Porras N, Alcazar D, Gaztambide J, et al. Adipose Tissue Characteristics Related to Weight Z-Score in Childhood, Int J Endocrinol Metab. Online ahead of Print ; 11(2):82-7. doi: 10.5812/ijem.8744.

ARTICLE INFORMATION

International Journal of Endocrinology and Metabolism: 11 (2); 82-7
Published Online: March 31, 2013
Article Type: Original Article
Received: October 22, 2012
Accepted: February 5, 2013
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Abstract

Background: Childhood obesity has grown very fast over recent decades and now it represents a serious public health problem. The number of adipocytes is set in childhood and adolescence and then, an effective understanding of the development of adipose tissue during these periods will help in the prevention of this pathology.

Objectives: The current study aimed to determine which adipose tissue characteristics are related to a high weight Z-score in childhood.

Patients and Methods: The current study included 82 children aged 5-130 months who underwent inguinal hernia surgery. Anthropometric variables were measured, and a nutritional and physical activity questionnaire was completed. Subcutaneous adipose tissue samples, taken during the operation, were analyzed for preadipocyte number, adipocyte volume, fatty acid composition (gas chromatography of FAME), and relative gene expression of various genes (real time PCR).

Results: The results showed that children with a higher weight Z-score spend more time in sedentary activities and less time running or involved in active games. SCD-1 activity index, arachidonic/linoleic index, and adipocyte volume were significantly higher in children with a weight Z-score greater than 0. The preadipocyte number and the genetic expression of the studied genes did not differ between the groups. A multiple regression analysis was done to determine which variables were related to the weight Z-score. R2 values indicated that the model which included adipocyte volume, SREBP-1c, SCD-1 expression, and activity index, predicted 59% of the variability in the weight Z-score among the children. The main variables associated with adipocyte volume were PPAR?, Adiponectin, CB1R expressions, as well as the SCD-1 activity and normalized weight.

Conclusions: It was concluded that in childhood, the weight Z-score is related to adipocyte volume and adipose tissue gene expression.

Keywords

Adipose Tissue Adipocyte Adipokines PPAR gamma Adiponectin

© 2013, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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